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Gene: NONO |
Gene summary for NONO |
Gene summary. |
Gene information | Species | Human | Gene symbol | NONO | Gene ID | 4841 |
Gene name | non-POU domain containing octamer binding | |
Gene Alias | MRXS34 | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0002218 | UniProtAcc | A0A0S2Z4Z9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4841 | NONO | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.23e-13 | 4.33e-01 | 0.0155 |
4841 | NONO | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.46e-03 | 4.21e-01 | -0.1808 |
4841 | NONO | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.35e-06 | 6.96e-01 | 0.0216 |
4841 | NONO | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.14e-12 | 7.21e-01 | -0.0811 |
4841 | NONO | HTA11_78_2000001011 | Human | Colorectum | AD | 1.23e-15 | 5.48e-01 | -0.1088 |
4841 | NONO | HTA11_347_2000001011 | Human | Colorectum | AD | 1.65e-21 | 7.20e-01 | -0.1954 |
4841 | NONO | HTA11_411_2000001011 | Human | Colorectum | SER | 2.90e-02 | 7.13e-01 | -0.2602 |
4841 | NONO | HTA11_83_2000001011 | Human | Colorectum | SER | 1.13e-02 | 2.55e-01 | -0.1526 |
4841 | NONO | HTA11_696_2000001011 | Human | Colorectum | AD | 1.05e-15 | 5.04e-01 | -0.1464 |
4841 | NONO | HTA11_866_2000001011 | Human | Colorectum | AD | 3.72e-06 | 3.65e-01 | -0.1001 |
4841 | NONO | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.04e-24 | 9.97e-01 | -0.059 |
4841 | NONO | HTA11_546_2000001011 | Human | Colorectum | AD | 5.56e-10 | 6.28e-01 | -0.0842 |
4841 | NONO | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.41e-12 | 7.72e-01 | -0.0179 |
4841 | NONO | HTA11_866_3004761011 | Human | Colorectum | AD | 3.85e-39 | 1.18e+00 | 0.096 |
4841 | NONO | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.21e-07 | 7.89e-01 | 0.0446 |
4841 | NONO | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.25e-11 | 9.43e-01 | 0.0528 |
4841 | NONO | HTA11_7663_2000001011 | Human | Colorectum | SER | 9.88e-12 | 9.21e-01 | 0.0131 |
4841 | NONO | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.22e-08 | 7.20e-01 | -0.0177 |
4841 | NONO | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.65e-14 | 1.17e+00 | 0.0171 |
4841 | NONO | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.80e-07 | 5.53e-01 | 0.0338 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:2001243 | Colorectum | AD | negative regulation of intrinsic apoptotic signaling pathway | 39/3918 | 98/18723 | 1.58e-05 | 3.34e-04 | 39 |
GO:0008631 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to oxidative stress | 22/3918 | 45/18723 | 2.77e-05 | 5.24e-04 | 22 |
GO:1902175 | Colorectum | AD | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 16/3918 | 29/18723 | 5.32e-05 | 9.01e-04 | 16 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
GO:0036473 | Colorectum | AD | cell death in response to oxidative stress | 35/3918 | 95/18723 | 2.58e-04 | 3.24e-03 | 35 |
GO:1903203 | Colorectum | AD | regulation of oxidative stress-induced neuron death | 14/3918 | 27/18723 | 3.72e-04 | 4.29e-03 | 14 |
GO:1903204 | Colorectum | AD | negative regulation of oxidative stress-induced neuron death | 11/3918 | 19/18723 | 4.66e-04 | 5.15e-03 | 11 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NONO | STM | Liver | Cirrhotic | MFSD9,HNRNPU,LCMT1, etc. | 4.68e-01 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NONO | SNV | Missense_Mutation | novel | c.1128T>A | p.Asp376Glu | p.D376E | Q15233 | protein_coding | tolerated(0.35) | benign(0.026) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NONO | SNV | Missense_Mutation | novel | c.1129G>T | p.Ala377Ser | p.A377S | Q15233 | protein_coding | tolerated(0.74) | benign(0.206) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NONO | SNV | Missense_Mutation | c.340A>C | p.Ile114Leu | p.I114L | Q15233 | protein_coding | tolerated(0.12) | benign(0.012) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NONO | SNV | Missense_Mutation | novel | c.580N>C | p.Glu194Gln | p.E194Q | Q15233 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-98-A53H-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NONO | deletion | Frame_Shift_Del | novel | c.570delA | p.Gly191AlafsTer25 | p.G191Afs*25 | Q15233 | protein_coding | TCGA-44-4112-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
NONO | SNV | Missense_Mutation | novel | c.623N>A | p.Cys208Tyr | p.C208Y | Q15233 | protein_coding | deleterious(0) | benign(0.444) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
NONO | SNV | Missense_Mutation | novel | c.635C>T | p.Ser212Phe | p.S212F | Q15233 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NONO | SNV | Missense_Mutation | rs779961109 | c.1091G>A | p.Arg364Gln | p.R364Q | Q15233 | protein_coding | tolerated(0.09) | benign(0.296) | TCGA-CV-A6JD-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NONO | SNV | Missense_Mutation | c.659G>A | p.Arg220His | p.R220H | Q15233 | protein_coding | tolerated(0.09) | benign(0.006) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
NONO | SNV | Missense_Mutation | novel | c.1402N>T | p.Arg468Cys | p.R468C | Q15233 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.973) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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