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Gene: NCAPG |
Gene summary for NCAPG |
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Gene information | Species | Human | Gene symbol | NCAPG | Gene ID | 64151 |
Gene name | non-SMC condensin I complex subunit G | |
Gene Alias | CAPG | |
Cytomap | 4p15.31 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9BPX3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64151 | NCAPG | LZE6T | Human | Esophagus | ESCC | 2.97e-05 | 2.41e-01 | 0.0845 |
64151 | NCAPG | P2T-E | Human | Esophagus | ESCC | 1.28e-06 | 3.54e-01 | 0.1177 |
64151 | NCAPG | P5T-E | Human | Esophagus | ESCC | 1.84e-06 | 1.72e-01 | 0.1327 |
64151 | NCAPG | P10T-E | Human | Esophagus | ESCC | 1.61e-03 | 1.47e-01 | 0.116 |
64151 | NCAPG | P24T-E | Human | Esophagus | ESCC | 3.04e-03 | 1.82e-01 | 0.1287 |
64151 | NCAPG | P28T-E | Human | Esophagus | ESCC | 5.13e-03 | 1.03e-01 | 0.1149 |
64151 | NCAPG | P31T-E | Human | Esophagus | ESCC | 3.58e-05 | 1.82e-01 | 0.1251 |
64151 | NCAPG | P32T-E | Human | Esophagus | ESCC | 3.60e-09 | 3.01e-01 | 0.1666 |
64151 | NCAPG | P36T-E | Human | Esophagus | ESCC | 1.70e-02 | 2.55e-01 | 0.1187 |
64151 | NCAPG | P37T-E | Human | Esophagus | ESCC | 2.81e-04 | 1.45e-01 | 0.1371 |
64151 | NCAPG | P52T-E | Human | Esophagus | ESCC | 8.80e-05 | 1.92e-01 | 0.1555 |
64151 | NCAPG | P74T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.50e-01 | 0.1479 |
64151 | NCAPG | P76T-E | Human | Esophagus | ESCC | 6.61e-06 | 2.29e-01 | 0.1207 |
64151 | NCAPG | P79T-E | Human | Esophagus | ESCC | 3.43e-02 | 1.81e-01 | 0.1154 |
64151 | NCAPG | P83T-E | Human | Esophagus | ESCC | 1.07e-08 | 3.41e-01 | 0.1738 |
64151 | NCAPG | P89T-E | Human | Esophagus | ESCC | 4.68e-04 | 4.50e-01 | 0.1752 |
64151 | NCAPG | P91T-E | Human | Esophagus | ESCC | 2.10e-06 | 8.27e-01 | 0.1828 |
64151 | NCAPG | P107T-E | Human | Esophagus | ESCC | 2.23e-12 | 4.98e-01 | 0.171 |
64151 | NCAPG | P130T-E | Human | Esophagus | ESCC | 2.32e-16 | 5.59e-01 | 0.1676 |
64151 | NCAPG | HCC1_Meng | Human | Liver | HCC | 2.09e-11 | 5.50e-02 | 0.0246 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0051348111 | Esophagus | ESCC | negative regulation of transferase activity | 177/8552 | 268/18723 | 1.08e-11 | 4.00e-10 | 177 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:003367319 | Esophagus | ESCC | negative regulation of kinase activity | 154/8552 | 237/18723 | 1.38e-09 | 3.27e-08 | 154 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:000646920 | Esophagus | ESCC | negative regulation of protein kinase activity | 140/8552 | 212/18723 | 1.53e-09 | 3.56e-08 | 140 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:0002262111 | Esophagus | ESCC | myeloid cell homeostasis | 104/8552 | 157/18723 | 1.49e-07 | 2.36e-06 | 104 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCAPG | SNV | Missense_Mutation | novel | c.1259N>A | p.Arg420Lys | p.R420K | Q9BPX3 | protein_coding | deleterious(0.04) | benign(0.124) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
NCAPG | SNV | Missense_Mutation | novel | c.558N>C | p.Leu186Phe | p.L186F | Q9BPX3 | protein_coding | deleterious(0.01) | possibly_damaging(0.779) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NCAPG | SNV | Missense_Mutation | novel | c.2704N>C | p.Gly902Arg | p.G902R | Q9BPX3 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NCAPG | SNV | Missense_Mutation | c.1465N>A | p.Glu489Lys | p.E489K | Q9BPX3 | protein_coding | tolerated(0.06) | benign(0.036) | TCGA-18-3414-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
NCAPG | SNV | Missense_Mutation | novel | c.1108N>C | p.Tyr370His | p.Y370H | Q9BPX3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-21-1075-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NCAPG | SNV | Missense_Mutation | novel | c.523N>A | p.Asp175Asn | p.D175N | Q9BPX3 | protein_coding | tolerated(0.15) | benign(0.035) | TCGA-21-1082-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NCAPG | SNV | Missense_Mutation | c.1526N>T | p.Cys509Phe | p.C509F | Q9BPX3 | protein_coding | deleterious(0.03) | benign(0.118) | TCGA-33-4532-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NCAPG | SNV | Missense_Mutation | c.2599N>T | p.Leu867Phe | p.L867F | Q9BPX3 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NCAPG | SNV | Missense_Mutation | novel | c.2227N>C | p.Glu743Gln | p.E743Q | Q9BPX3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NCAPG | SNV | Missense_Mutation | novel | c.1006G>T | p.Ala336Ser | p.A336S | Q9BPX3 | protein_coding | tolerated(0.21) | benign(0.147) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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