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Gene: NARS2 |
Gene summary for NARS2 |
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Gene information | Species | Human | Gene symbol | NARS2 | Gene ID | 79731 |
Gene name | asparaginyl-tRNA synthetase 2, mitochondrial | |
Gene Alias | DFNB94 | |
Cytomap | 11q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | B3KPX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79731 | NARS2 | LZE8T | Human | Esophagus | ESCC | 1.61e-03 | 1.24e-01 | 0.067 |
79731 | NARS2 | LZE24T | Human | Esophagus | ESCC | 1.70e-14 | 2.72e-01 | 0.0596 |
79731 | NARS2 | P2T-E | Human | Esophagus | ESCC | 1.04e-14 | 2.53e-01 | 0.1177 |
79731 | NARS2 | P4T-E | Human | Esophagus | ESCC | 3.76e-20 | 4.97e-01 | 0.1323 |
79731 | NARS2 | P5T-E | Human | Esophagus | ESCC | 9.88e-09 | 8.48e-02 | 0.1327 |
79731 | NARS2 | P8T-E | Human | Esophagus | ESCC | 2.55e-02 | 5.34e-02 | 0.0889 |
79731 | NARS2 | P9T-E | Human | Esophagus | ESCC | 7.96e-09 | 2.02e-01 | 0.1131 |
79731 | NARS2 | P10T-E | Human | Esophagus | ESCC | 1.61e-20 | 3.51e-01 | 0.116 |
79731 | NARS2 | P11T-E | Human | Esophagus | ESCC | 4.75e-08 | 3.04e-01 | 0.1426 |
79731 | NARS2 | P12T-E | Human | Esophagus | ESCC | 2.29e-18 | 3.33e-01 | 0.1122 |
79731 | NARS2 | P15T-E | Human | Esophagus | ESCC | 1.45e-20 | 5.47e-01 | 0.1149 |
79731 | NARS2 | P16T-E | Human | Esophagus | ESCC | 1.68e-16 | 3.08e-01 | 0.1153 |
79731 | NARS2 | P17T-E | Human | Esophagus | ESCC | 3.86e-03 | 2.37e-01 | 0.1278 |
79731 | NARS2 | P19T-E | Human | Esophagus | ESCC | 1.43e-05 | 6.41e-01 | 0.1662 |
79731 | NARS2 | P20T-E | Human | Esophagus | ESCC | 8.92e-06 | 1.14e-01 | 0.1124 |
79731 | NARS2 | P21T-E | Human | Esophagus | ESCC | 8.45e-24 | 4.22e-01 | 0.1617 |
79731 | NARS2 | P22T-E | Human | Esophagus | ESCC | 4.06e-12 | 1.82e-01 | 0.1236 |
79731 | NARS2 | P23T-E | Human | Esophagus | ESCC | 2.17e-09 | 1.89e-01 | 0.108 |
79731 | NARS2 | P24T-E | Human | Esophagus | ESCC | 1.52e-05 | 1.07e-01 | 0.1287 |
79731 | NARS2 | P26T-E | Human | Esophagus | ESCC | 2.28e-11 | 2.87e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NARS2 | SNV | Missense_Mutation | rs569629223 | c.1159N>T | p.His387Tyr | p.H387Y | Q96I59 | protein_coding | deleterious(0) | possibly_damaging(0.659) | TCGA-52-7622-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NARS2 | SNV | Missense_Mutation | c.1104T>G | p.Asn368Lys | p.N368K | Q96I59 | protein_coding | deleterious(0) | possibly_damaging(0.659) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
NARS2 | SNV | Missense_Mutation | novel | c.1087C>A | p.Pro363Thr | p.P363T | Q96I59 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-77-8153-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NARS2 | insertion | In_Frame_Ins | novel | c.94_95insCCC | p.Asp32delinsAlaHis | p.D32delinsAH | Q96I59 | protein_coding | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
NARS2 | insertion | In_Frame_Ins | novel | c.93_94insCTGGTCCAAGCTACAGTGCAA | p.Arg31_Asp32insLeuValGlnAlaThrValGln | p.R31_D32insLVQATVQ | Q96I59 | protein_coding | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
NARS2 | SNV | Missense_Mutation | rs769118312 | c.451G>A | p.Val151Ile | p.V151I | Q96I59 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-HD-7831-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NARS2 | SNV | Missense_Mutation | novel | c.803N>A | p.Ser268Asn | p.S268N | Q96I59 | protein_coding | tolerated(0.35) | benign(0.014) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NARS2 | SNV | Missense_Mutation | rs757944504 | c.476G>A | p.Arg159His | p.R159H | Q96I59 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D7-A748-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
NARS2 | SNV | Missense_Mutation | novel | c.572N>T | p.Ala191Val | p.A191V | Q96I59 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-MX-A666-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | SD |
NARS2 | SNV | Missense_Mutation | novel | c.452T>C | p.Val151Ala | p.V151A | Q96I59 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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