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Gene: NAALADL2 |
Gene summary for NAALADL2 |
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Gene information | Species | Human | Gene symbol | NAALADL2 | Gene ID | 254827 |
Gene name | N-acetylated alpha-linked acidic dipeptidase like 2 | |
Gene Alias | NAALADL2 | |
Cytomap | 3q26.31 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q58DX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254827 | NAALADL2 | CCI_1 | Human | Cervix | CC | 9.80e-15 | 1.74e+00 | 0.528 |
254827 | NAALADL2 | CCI_2 | Human | Cervix | CC | 4.12e-15 | 1.83e+00 | 0.5249 |
254827 | NAALADL2 | CCI_3 | Human | Cervix | CC | 5.62e-30 | 1.69e+00 | 0.516 |
254827 | NAALADL2 | CCII_1 | Human | Cervix | CC | 1.97e-05 | 2.56e-01 | 0.3249 |
254827 | NAALADL2 | T1 | Human | Cervix | CC | 2.13e-05 | 2.29e-01 | 0.0918 |
254827 | NAALADL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.58e-24 | -5.93e-01 | 0.0155 |
254827 | NAALADL2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.18e-04 | -2.92e-01 | -0.1808 |
254827 | NAALADL2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.00e-10 | -6.31e-01 | 0.0216 |
254827 | NAALADL2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.04e-05 | 5.15e-01 | -0.1088 |
254827 | NAALADL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.73e-23 | 9.15e-01 | -0.1954 |
254827 | NAALADL2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.89e-03 | -5.97e-01 | -0.2196 |
254827 | NAALADL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.91e-17 | -7.46e-01 | -0.1207 |
254827 | NAALADL2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.50e-05 | -6.50e-01 | -0.2061 |
254827 | NAALADL2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.17e-07 | -4.86e-01 | -0.1462 |
254827 | NAALADL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.18e-05 | -5.11e-01 | 0.0528 |
254827 | NAALADL2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.01e-02 | 3.41e-01 | 0.0131 |
254827 | NAALADL2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.67e-08 | 7.47e-01 | 0.281 |
254827 | NAALADL2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.45e-38 | -1.33e+00 | 0.2585 |
254827 | NAALADL2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.75e-14 | -5.43e-01 | 0.3005 |
254827 | NAALADL2 | A015-C-203 | Human | Colorectum | FAP | 6.08e-18 | -3.97e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAALADL2 | SNV | Missense_Mutation | novel | c.1774G>C | p.Ala592Pro | p.A592P | Q58DX5 | protein_coding | tolerated(0.12) | possibly_damaging(0.478) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NAALADL2 | SNV | Missense_Mutation | c.838N>T | p.Ser280Cys | p.S280C | Q58DX5 | protein_coding | tolerated(0.05) | benign(0.319) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
NAALADL2 | SNV | Missense_Mutation | rs778343683 | c.1469N>G | p.Thr490Ser | p.T490S | Q58DX5 | protein_coding | tolerated(0.06) | benign(0.156) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
NAALADL2 | SNV | Missense_Mutation | c.2279N>T | p.Glu760Val | p.E760V | Q58DX5 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NAALADL2 | SNV | Missense_Mutation | novel | c.1355N>G | p.His452Arg | p.H452R | Q58DX5 | protein_coding | tolerated(0.46) | probably_damaging(0.998) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NAALADL2 | SNV | Missense_Mutation | c.2120N>A | p.Met707Lys | p.M707K | Q58DX5 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-55-8510-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NAALADL2 | SNV | Missense_Mutation | c.1726N>C | p.Asp576His | p.D576H | Q58DX5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8620-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
NAALADL2 | SNV | Missense_Mutation | c.2245N>T | p.Ala749Ser | p.A749S | Q58DX5 | protein_coding | deleterious(0.01) | benign(0.398) | TCGA-73-4677-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NAALADL2 | SNV | Missense_Mutation | novel | c.1363N>T | p.Ala455Ser | p.A455S | Q58DX5 | protein_coding | tolerated(0.75) | benign(0.007) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
NAALADL2 | SNV | Missense_Mutation | novel | c.1230T>A | p.Asn410Lys | p.N410K | Q58DX5 | protein_coding | tolerated(0.2) | benign(0.026) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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