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Gene: NAALADL1 |
Gene summary for NAALADL1 |
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Gene information | Species | Human | Gene symbol | NAALADL1 | Gene ID | 10004 |
Gene name | N-acetylated alpha-linked acidic dipeptidase like 1 | |
Gene Alias | I100 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9UQQ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10004 | NAALADL1 | S014 | Human | Liver | HCC | 5.79e-11 | 3.72e-01 | 0.2254 |
10004 | NAALADL1 | S015 | Human | Liver | HCC | 3.30e-26 | 8.05e-01 | 0.2375 |
10004 | NAALADL1 | S016 | Human | Liver | HCC | 2.69e-25 | 6.94e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAALADL1 | SNV | Missense_Mutation | c.904N>G | p.Leu302Val | p.L302V | Q9UQQ1 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NAALADL1 | SNV | Missense_Mutation | c.1213C>T | p.Arg405Cys | p.R405C | Q9UQQ1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NAALADL1 | SNV | Missense_Mutation | c.896N>T | p.Asn299Ile | p.N299I | Q9UQQ1 | protein_coding | deleterious(0.03) | benign(0.042) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | |
NAALADL1 | SNV | Missense_Mutation | c.232N>T | p.Asp78Tyr | p.D78Y | Q9UQQ1 | protein_coding | deleterious(0.04) | benign(0.285) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD | |
NAALADL1 | SNV | Missense_Mutation | novel | c.295G>A | p.Ala99Thr | p.A99T | Q9UQQ1 | protein_coding | tolerated(0.58) | benign(0) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NAALADL1 | SNV | Missense_Mutation | rs772880783 | c.691G>A | p.Glu231Lys | p.E231K | Q9UQQ1 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NAALADL1 | SNV | Missense_Mutation | c.416N>T | p.Gly139Val | p.G139V | Q9UQQ1 | protein_coding | tolerated(0.07) | benign(0.019) | TCGA-18-4083-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
NAALADL1 | SNV | Missense_Mutation | rs761030005 | c.760N>A | p.Gly254Arg | p.G254R | Q9UQQ1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
NAALADL1 | SNV | Missense_Mutation | c.267N>A | p.Asp89Glu | p.D89E | Q9UQQ1 | protein_coding | deleterious(0) | benign(0.339) | TCGA-22-4601-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
NAALADL1 | SNV | Missense_Mutation | rs752886257 | c.737N>A | p.Arg246Gln | p.R246Q | Q9UQQ1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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