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Gene: MYBL2 |
Gene summary for MYBL2 |
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Gene information | Species | Human | Gene symbol | MYBL2 | Gene ID | 4605 |
Gene name | MYB proto-oncogene like 2 | |
Gene Alias | B-MYB | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P10244 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4605 | MYBL2 | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 3.36e-01 | 0.068 |
4605 | MYBL2 | P2T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.67e-01 | 0.1177 |
4605 | MYBL2 | P4T-E | Human | Esophagus | ESCC | 2.23e-06 | 2.03e-01 | 0.1323 |
4605 | MYBL2 | P5T-E | Human | Esophagus | ESCC | 5.79e-16 | 3.76e-01 | 0.1327 |
4605 | MYBL2 | P10T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.75e-01 | 0.116 |
4605 | MYBL2 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.35e-01 | 0.1149 |
4605 | MYBL2 | P16T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.50e-01 | 0.1153 |
4605 | MYBL2 | P17T-E | Human | Esophagus | ESCC | 1.29e-08 | 5.97e-01 | 0.1278 |
4605 | MYBL2 | P21T-E | Human | Esophagus | ESCC | 3.89e-12 | 3.50e-01 | 0.1617 |
4605 | MYBL2 | P22T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.07e-01 | 0.1236 |
4605 | MYBL2 | P24T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.97e-01 | 0.1287 |
4605 | MYBL2 | P26T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.99e-01 | 0.1276 |
4605 | MYBL2 | P28T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.60e-01 | 0.1149 |
4605 | MYBL2 | P31T-E | Human | Esophagus | ESCC | 9.02e-11 | 3.86e-01 | 0.1251 |
4605 | MYBL2 | P32T-E | Human | Esophagus | ESCC | 5.30e-21 | 4.68e-01 | 0.1666 |
4605 | MYBL2 | P37T-E | Human | Esophagus | ESCC | 4.26e-12 | 3.30e-01 | 0.1371 |
4605 | MYBL2 | P38T-E | Human | Esophagus | ESCC | 1.00e-03 | 2.63e-01 | 0.127 |
4605 | MYBL2 | P47T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.79e-02 | 0.1067 |
4605 | MYBL2 | P49T-E | Human | Esophagus | ESCC | 7.48e-03 | 8.13e-01 | 0.1768 |
4605 | MYBL2 | P52T-E | Human | Esophagus | ESCC | 2.56e-16 | 4.29e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:009030715 | Esophagus | ESCC | mitotic spindle assembly | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:0051402110 | Esophagus | ESCC | neuron apoptotic process | 148/8552 | 246/18723 | 3.08e-06 | 3.47e-05 | 148 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:1901216111 | Esophagus | ESCC | positive regulation of neuron death | 65/8552 | 97/18723 | 1.76e-05 | 1.56e-04 | 65 |
GO:0043525110 | Esophagus | ESCC | positive regulation of neuron apoptotic process | 40/8552 | 58/18723 | 2.83e-04 | 1.71e-03 | 40 |
GO:004352317 | Esophagus | ESCC | regulation of neuron apoptotic process | 122/8552 | 212/18723 | 3.21e-04 | 1.90e-03 | 122 |
GO:199082316 | Esophagus | ESCC | response to leukemia inhibitory factor | 60/8552 | 95/18723 | 4.41e-04 | 2.48e-03 | 60 |
GO:199083015 | Esophagus | ESCC | cellular response to leukemia inhibitory factor | 59/8552 | 94/18723 | 6.19e-04 | 3.32e-03 | 59 |
GO:014001411 | Liver | HCC | mitotic nuclear division | 174/7958 | 287/18723 | 3.74e-10 | 1.23e-08 | 174 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:000705211 | Liver | HCC | mitotic spindle organization | 80/7958 | 120/18723 | 7.43e-08 | 1.50e-06 | 80 |
GO:007099722 | Liver | HCC | neuron death | 202/7958 | 361/18723 | 1.44e-07 | 2.70e-06 | 202 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421829 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0421838 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0421822 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa0421832 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa0421820 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
hsa04218110 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYBL2 | SNV | Missense_Mutation | novel | c.946G>A | p.Glu316Lys | p.E316K | P10244 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYBL2 | SNV | Missense_Mutation | novel | c.1993A>G | p.Thr665Ala | p.T665A | P10244 | protein_coding | tolerated(0.89) | benign(0) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYBL2 | SNV | Missense_Mutation | novel | c.898C>A | p.Leu300Ile | p.L300I | P10244 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MYBL2 | insertion | Nonsense_Mutation | novel | c.1049_1050insCCTTAGCTCAGCTTCCTTGGTATGAAAGGGAA | p.His351LeufsTer8 | p.H351Lfs*8 | P10244 | protein_coding | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MYBL2 | SNV | Missense_Mutation | c.1333N>G | p.Pro445Ala | p.P445A | P10244 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-BC-A10U-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MYBL2 | SNV | Missense_Mutation | novel | c.1922N>T | p.Glu641Val | p.E641V | P10244 | protein_coding | deleterious(0.03) | benign(0.203) | TCGA-ZP-A9D1-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYBL2 | SNV | Missense_Mutation | novel | c.1936N>T | p.Ala646Ser | p.A646S | P10244 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
MYBL2 | SNV | Missense_Mutation | c.1183N>T | p.Ser395Cys | p.S395C | P10244 | protein_coding | tolerated(0.09) | possibly_damaging(0.628) | TCGA-38-4626-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MYBL2 | SNV | Missense_Mutation | c.1693N>T | p.Pro565Ser | p.P565S | P10244 | protein_coding | tolerated(0.12) | possibly_damaging(0.898) | TCGA-44-2657-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYBL2 | SNV | Missense_Mutation | novel | c.1536N>T | p.Met512Ile | p.M512I | P10244 | protein_coding | deleterious(0.04) | benign(0.014) | TCGA-49-4514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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