GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190495115 | Endometrium | AEH | positive regulation of establishment of protein localization | 74/2100 | 319/18723 | 7.05e-10 | 6.51e-08 | 74 |
GO:190382916 | Endometrium | AEH | positive regulation of cellular protein localization | 66/2100 | 276/18723 | 1.57e-09 | 1.36e-07 | 66 |
GO:000716310 | Endometrium | AEH | establishment or maintenance of cell polarity | 54/2100 | 218/18723 | 1.30e-08 | 8.47e-07 | 54 |
GO:000660516 | Endometrium | AEH | protein targeting | 68/2100 | 314/18723 | 6.30e-08 | 3.38e-06 | 68 |
GO:005122215 | Endometrium | AEH | positive regulation of protein transport | 66/2100 | 303/18723 | 7.79e-08 | 3.99e-06 | 66 |
GO:003315710 | Endometrium | AEH | regulation of intracellular protein transport | 51/2100 | 229/18723 | 1.13e-06 | 3.75e-05 | 51 |
GO:003238810 | Endometrium | AEH | positive regulation of intracellular transport | 46/2100 | 202/18723 | 1.96e-06 | 5.93e-05 | 46 |
GO:00323869 | Endometrium | AEH | regulation of intracellular transport | 66/2100 | 337/18723 | 4.18e-06 | 1.10e-04 | 66 |
GO:00903168 | Endometrium | AEH | positive regulation of intracellular protein transport | 38/2100 | 160/18723 | 5.22e-06 | 1.33e-04 | 38 |
GO:009015010 | Endometrium | AEH | establishment of protein localization to membrane | 51/2100 | 260/18723 | 4.74e-05 | 7.85e-04 | 51 |
GO:19054779 | Endometrium | AEH | positive regulation of protein localization to membrane | 26/2100 | 106/18723 | 8.63e-05 | 1.27e-03 | 26 |
GO:00350886 | Endometrium | AEH | establishment or maintenance of apical/basal cell polarity | 14/2100 | 49/18723 | 7.19e-04 | 6.90e-03 | 14 |
GO:00612456 | Endometrium | AEH | establishment or maintenance of bipolar cell polarity | 14/2100 | 49/18723 | 7.19e-04 | 6.90e-03 | 14 |
GO:00451976 | Endometrium | AEH | establishment or maintenance of epithelial cell apical/basal polarity | 13/2100 | 44/18723 | 7.79e-04 | 7.36e-03 | 13 |
GO:19054759 | Endometrium | AEH | regulation of protein localization to membrane | 34/2100 | 175/18723 | 9.62e-04 | 8.75e-03 | 34 |
GO:00105068 | Endometrium | AEH | regulation of autophagy | 54/2100 | 317/18723 | 1.15e-03 | 9.97e-03 | 54 |
GO:19035335 | Endometrium | AEH | regulation of protein targeting | 18/2100 | 81/18723 | 3.28e-03 | 2.30e-02 | 18 |
GO:190382917 | Endometrium | EEC | positive regulation of cellular protein localization | 67/2168 | 276/18723 | 2.27e-09 | 1.84e-07 | 67 |
GO:190495116 | Endometrium | EEC | positive regulation of establishment of protein localization | 74/2168 | 319/18723 | 2.90e-09 | 2.10e-07 | 74 |
GO:000716315 | Endometrium | EEC | establishment or maintenance of cell polarity | 56/2168 | 218/18723 | 5.41e-09 | 3.57e-07 | 56 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTCL1 | SNV | Missense_Mutation | rs745335148 | c.4478N>T | p.Ser1493Leu | p.S1493L | Q9Y4B5 | protein_coding | deleterious(0.01) | benign(0.132) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTCL1 | SNV | Missense_Mutation | rs368971612 | c.676G>A | p.Val226Met | p.V226M | Q9Y4B5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
MTCL1 | SNV | Missense_Mutation | novel | c.3757N>A | p.Ala1253Thr | p.A1253T | Q9Y4B5 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MTCL1 | SNV | Missense_Mutation | rs754737702 | c.668G>A | p.Arg223Gln | p.R223Q | Q9Y4B5 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MTCL1 | SNV | Missense_Mutation | rs766629891 | c.3146G>A | p.Arg1049His | p.R1049H | Q9Y4B5 | protein_coding | tolerated(0.2) | benign(0) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MTCL1 | SNV | Missense_Mutation | novel | c.2472G>T | p.Lys824Asn | p.K824N | Q9Y4B5 | protein_coding | deleterious(0) | possibly_damaging(0.684) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTCL1 | SNV | Missense_Mutation | | c.2026N>A | p.Leu676Ile | p.L676I | Q9Y4B5 | protein_coding | tolerated(0.14) | benign(0.307) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTCL1 | SNV | Missense_Mutation | rs369827156 | c.478N>T | p.Arg160Cys | p.R160C | Q9Y4B5 | protein_coding | tolerated(0.19) | probably_damaging(0.972) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTCL1 | SNV | Missense_Mutation | | c.2622N>T | p.Glu874Asp | p.E874D | Q9Y4B5 | protein_coding | tolerated(0.41) | possibly_damaging(0.772) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTCL1 | SNV | Missense_Mutation | | c.3316N>A | p.Leu1106Ile | p.L1106I | Q9Y4B5 | protein_coding | tolerated(0.08) | probably_damaging(0.998) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |