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Gene: MPP1 |
Gene summary for MPP1 |
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Gene information | Species | Human | Gene symbol | MPP1 | Gene ID | 4354 |
Gene name | membrane palmitoylated protein 1 | |
Gene Alias | AAG12 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | B4E325 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4354 | MPP1 | LZE4T | Human | Esophagus | ESCC | 4.39e-03 | 1.71e-01 | 0.0811 |
4354 | MPP1 | LZE7T | Human | Esophagus | ESCC | 1.67e-02 | 2.02e-01 | 0.0667 |
4354 | MPP1 | P2T-E | Human | Esophagus | ESCC | 1.64e-15 | 2.62e-01 | 0.1177 |
4354 | MPP1 | P9T-E | Human | Esophagus | ESCC | 1.80e-02 | 1.37e-01 | 0.1131 |
4354 | MPP1 | P10T-E | Human | Esophagus | ESCC | 1.19e-09 | 1.78e-01 | 0.116 |
4354 | MPP1 | P11T-E | Human | Esophagus | ESCC | 1.09e-05 | 2.40e-01 | 0.1426 |
4354 | MPP1 | P22T-E | Human | Esophagus | ESCC | 5.10e-57 | 8.91e-01 | 0.1236 |
4354 | MPP1 | P23T-E | Human | Esophagus | ESCC | 1.37e-03 | 1.30e-01 | 0.108 |
4354 | MPP1 | P24T-E | Human | Esophagus | ESCC | 1.34e-02 | 4.59e-02 | 0.1287 |
4354 | MPP1 | P26T-E | Human | Esophagus | ESCC | 2.37e-02 | 1.27e-01 | 0.1276 |
4354 | MPP1 | P28T-E | Human | Esophagus | ESCC | 1.07e-02 | 9.66e-02 | 0.1149 |
4354 | MPP1 | P32T-E | Human | Esophagus | ESCC | 6.02e-04 | 1.39e-01 | 0.1666 |
4354 | MPP1 | P47T-E | Human | Esophagus | ESCC | 2.73e-02 | 7.80e-02 | 0.1067 |
4354 | MPP1 | P52T-E | Human | Esophagus | ESCC | 9.38e-09 | 2.09e-01 | 0.1555 |
4354 | MPP1 | P76T-E | Human | Esophagus | ESCC | 7.96e-08 | 2.26e-01 | 0.1207 |
4354 | MPP1 | P80T-E | Human | Esophagus | ESCC | 6.58e-09 | 2.70e-01 | 0.155 |
4354 | MPP1 | P89T-E | Human | Esophagus | ESCC | 4.23e-04 | 2.86e-01 | 0.1752 |
4354 | MPP1 | P91T-E | Human | Esophagus | ESCC | 1.43e-05 | 7.05e-01 | 0.1828 |
4354 | MPP1 | P107T-E | Human | Esophagus | ESCC | 1.06e-08 | 2.11e-01 | 0.171 |
4354 | MPP1 | cirrhotic1 | Human | Liver | Cirrhotic | 2.44e-02 | 9.63e-02 | 0.0202 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:000913219 | Esophagus | ESCC | nucleoside diphosphate metabolic process | 77/8552 | 124/18723 | 1.65e-04 | 1.09e-03 | 77 |
GO:000918520 | Esophagus | ESCC | ribonucleoside diphosphate metabolic process | 66/8552 | 106/18723 | 4.21e-04 | 2.39e-03 | 66 |
GO:00091234 | Esophagus | ESCC | nucleoside monophosphate metabolic process | 49/8552 | 76/18723 | 7.30e-04 | 3.80e-03 | 49 |
GO:000913520 | Esophagus | ESCC | purine nucleoside diphosphate metabolic process | 63/8552 | 103/18723 | 1.10e-03 | 5.52e-03 | 63 |
GO:000917920 | Esophagus | ESCC | purine ribonucleoside diphosphate metabolic process | 63/8552 | 103/18723 | 1.10e-03 | 5.52e-03 | 63 |
GO:00091615 | Esophagus | ESCC | ribonucleoside monophosphate metabolic process | 38/8552 | 58/18723 | 1.81e-03 | 8.32e-03 | 38 |
GO:00091269 | Esophagus | ESCC | purine nucleoside monophosphate metabolic process | 30/8552 | 44/18723 | 2.14e-03 | 9.54e-03 | 30 |
GO:000268515 | Esophagus | ESCC | regulation of leukocyte migration | 114/8552 | 210/18723 | 7.26e-03 | 2.63e-02 | 114 |
GO:00091678 | Esophagus | ESCC | purine ribonucleoside monophosphate metabolic process | 27/8552 | 41/18723 | 7.31e-03 | 2.63e-02 | 27 |
GO:000675312 | Liver | Cirrhotic | nucleoside phosphate metabolic process | 190/4634 | 497/18723 | 1.10e-11 | 6.96e-10 | 190 |
GO:000911712 | Liver | Cirrhotic | nucleotide metabolic process | 187/4634 | 489/18723 | 1.55e-11 | 9.63e-10 | 187 |
GO:001969312 | Liver | Cirrhotic | ribose phosphate metabolic process | 156/4634 | 396/18723 | 5.83e-11 | 3.23e-09 | 156 |
GO:000925912 | Liver | Cirrhotic | ribonucleotide metabolic process | 151/4634 | 385/18723 | 1.72e-10 | 8.70e-09 | 151 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPP1 | SNV | Missense_Mutation | rs374791319 | c.289G>A | p.Ala97Thr | p.A97T | Q00013 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
MPP1 | insertion | Nonsense_Mutation | novel | c.835_836insTTTAGTTT | p.Ala279ValfsTer2 | p.A279Vfs*2 | Q00013 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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