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Gene: MOCOS |
Gene summary for MOCOS |
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Gene information | Species | Human | Gene symbol | MOCOS | Gene ID | 55034 |
Gene name | molybdenum cofactor sulfurase | |
Gene Alias | HMCS | |
Cytomap | 18q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006777 | UniProtAcc | Q96EN8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55034 | MOCOS | P1T-E | Human | Esophagus | ESCC | 1.42e-03 | 2.69e-01 | 0.0875 |
55034 | MOCOS | P2T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.08e-01 | 0.1177 |
55034 | MOCOS | P5T-E | Human | Esophagus | ESCC | 1.51e-04 | 1.41e-01 | 0.1327 |
55034 | MOCOS | P9T-E | Human | Esophagus | ESCC | 1.20e-09 | 2.82e-01 | 0.1131 |
55034 | MOCOS | P11T-E | Human | Esophagus | ESCC | 5.11e-04 | 2.57e-01 | 0.1426 |
55034 | MOCOS | P17T-E | Human | Esophagus | ESCC | 1.52e-03 | 2.76e-01 | 0.1278 |
55034 | MOCOS | P19T-E | Human | Esophagus | ESCC | 3.92e-06 | 6.40e-01 | 0.1662 |
55034 | MOCOS | P20T-E | Human | Esophagus | ESCC | 2.22e-03 | 9.29e-02 | 0.1124 |
55034 | MOCOS | P21T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.13e-01 | 0.1617 |
55034 | MOCOS | P23T-E | Human | Esophagus | ESCC | 4.39e-06 | 2.89e-01 | 0.108 |
55034 | MOCOS | P24T-E | Human | Esophagus | ESCC | 3.95e-30 | 6.46e-01 | 0.1287 |
55034 | MOCOS | P26T-E | Human | Esophagus | ESCC | 1.02e-02 | 1.67e-01 | 0.1276 |
55034 | MOCOS | P36T-E | Human | Esophagus | ESCC | 1.01e-09 | 3.81e-01 | 0.1187 |
55034 | MOCOS | P37T-E | Human | Esophagus | ESCC | 6.43e-03 | 1.10e-01 | 0.1371 |
55034 | MOCOS | P40T-E | Human | Esophagus | ESCC | 1.15e-04 | 1.74e-01 | 0.109 |
55034 | MOCOS | P42T-E | Human | Esophagus | ESCC | 2.51e-04 | 1.26e-01 | 0.1175 |
55034 | MOCOS | P47T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.50e-02 | 0.1067 |
55034 | MOCOS | P52T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.87e-01 | 0.1555 |
55034 | MOCOS | P54T-E | Human | Esophagus | ESCC | 4.42e-03 | 1.62e-01 | 0.0975 |
55034 | MOCOS | P62T-E | Human | Esophagus | ESCC | 1.53e-10 | 2.34e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOCOS | SNV | Missense_Mutation | c.1129N>A | p.Asp377Asn | p.D377N | Q96EN8 | protein_coding | tolerated(0.06) | benign(0.141) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MOCOS | SNV | Missense_Mutation | novel | c.221A>G | p.Glu74Gly | p.E74G | Q96EN8 | protein_coding | tolerated(0.14) | benign(0.012) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MOCOS | SNV | Missense_Mutation | novel | c.2096G>A | p.Gly699Asp | p.G699D | Q96EN8 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MOCOS | SNV | Missense_Mutation | novel | c.859N>G | p.Lys287Glu | p.K287E | Q96EN8 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOCOS | SNV | Missense_Mutation | rs199870151 | c.979N>A | p.Ala327Thr | p.A327T | Q96EN8 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOCOS | insertion | Frame_Shift_Ins | novel | c.1668_1669insTTCATTAGGAATAATTTGAGTGGCAAAGA | p.Val557PhefsTer54 | p.V557Ffs*54 | Q96EN8 | protein_coding | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MOCOS | deletion | Frame_Shift_Del | rs755830405 | c.*6delA | Q96EN8 | protein_coding | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||||
MOCOS | deletion | Frame_Shift_Del | rs755830405 | c.*6delA | Q96EN8 | protein_coding | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | ||||
MOCOS | deletion | Frame_Shift_Del | rs755830405 | c.2666delN | p.Ter889%3D | p.*889%3D | Q96EN8 | protein_coding | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD | ||
MOCOS | deletion | Frame_Shift_Del | rs755830405 | c.*6delA | Q96EN8 | protein_coding | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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