![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MGAM2 |
Gene summary for MGAM2 |
![]() |
Gene information | Species | Human | Gene symbol | MGAM2 | Gene ID | 93432 |
Gene name | maltase-glucoamylase 2 (putative) | |
Gene Alias | MGAM2 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q2M2H8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93432 | MGAM2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.60e-08 | 3.39e-01 | -0.059 |
93432 | MGAM2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.19e-05 | 1.14e+00 | 0.3487 |
93432 | MGAM2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.30e-26 | 9.21e-01 | 0.281 |
93432 | MGAM2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.12e-25 | 5.48e-01 | 0.3859 |
93432 | MGAM2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.10e-16 | 4.26e-01 | 0.3005 |
93432 | MGAM2 | A001-C-007 | Human | Colorectum | CRC | 1.37e-12 | 6.30e-01 | 0.1899 |
93432 | MGAM2 | F072B | Human | Colorectum | FAP | 2.11e-24 | 6.74e-01 | 0.257 |
93432 | MGAM2 | CRC-1-8810 | Human | Colorectum | CRC | 9.17e-50 | 1.04e+00 | 0.6257 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGAM2 | SNV | Missense_Mutation | novel | c.2227G>A | p.Ala743Thr | p.A743T | Q2M2H8 | protein_coding | tolerated(0.15) | possibly_damaging(0.626) | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MGAM2 | SNV | Missense_Mutation | novel | c.6029N>A | p.Ser2010Asn | p.S2010N | Q2M2H8 | protein_coding | tolerated_low_confidence(0.3) | unknown(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.2309N>C | p.Phe770Ser | p.F770S | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | rs373613400 | c.4024N>T | p.Arg1342Cys | p.R1342C | Q2M2H8 | protein_coding | deleterious(0.02) | possibly_damaging(0.493) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.6800N>A | p.Pro2267His | p.P2267H | Q2M2H8 | protein_coding | deleterious_low_confidence(0) | unknown(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | rs370725960 | c.560G>A | p.Ser187Asn | p.S187N | Q2M2H8 | protein_coding | deleterious(0) | benign(0.071) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.862C>T | p.Pro288Ser | p.P288S | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.211T>C | p.Cys71Arg | p.C71R | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | rs567505779 | c.2044C>T | p.Arg682Trp | p.R682W | Q2M2H8 | protein_coding | tolerated(0.18) | benign(0.051) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | rs777073088 | c.3337N>T | p.Asp1113Tyr | p.D1113Y | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BK-A139-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |