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Gene: MAPK7 |
Gene summary for MAPK7 |
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Gene information | Species | Human | Gene symbol | MAPK7 | Gene ID | 5598 |
Gene name | mitogen-activated protein kinase 7 | |
Gene Alias | BMK1 | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024QZ20 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5598 | MAPK7 | LZE4T | Human | Esophagus | ESCC | 3.03e-03 | 1.02e-01 | 0.0811 |
5598 | MAPK7 | LZE24T | Human | Esophagus | ESCC | 3.06e-11 | 2.33e-01 | 0.0596 |
5598 | MAPK7 | P1T-E | Human | Esophagus | ESCC | 2.41e-07 | 3.63e-01 | 0.0875 |
5598 | MAPK7 | P2T-E | Human | Esophagus | ESCC | 1.65e-10 | 1.77e-01 | 0.1177 |
5598 | MAPK7 | P4T-E | Human | Esophagus | ESCC | 4.11e-06 | 1.17e-01 | 0.1323 |
5598 | MAPK7 | P8T-E | Human | Esophagus | ESCC | 5.87e-06 | 1.49e-01 | 0.0889 |
5598 | MAPK7 | P9T-E | Human | Esophagus | ESCC | 7.67e-08 | 1.10e-01 | 0.1131 |
5598 | MAPK7 | P10T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.87e-01 | 0.116 |
5598 | MAPK7 | P11T-E | Human | Esophagus | ESCC | 3.10e-10 | 3.96e-01 | 0.1426 |
5598 | MAPK7 | P12T-E | Human | Esophagus | ESCC | 8.08e-19 | 2.91e-01 | 0.1122 |
5598 | MAPK7 | P15T-E | Human | Esophagus | ESCC | 7.19e-09 | 1.04e-01 | 0.1149 |
5598 | MAPK7 | P16T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.98e-01 | 0.1153 |
5598 | MAPK7 | P17T-E | Human | Esophagus | ESCC | 5.97e-05 | 2.65e-01 | 0.1278 |
5598 | MAPK7 | P20T-E | Human | Esophagus | ESCC | 6.13e-11 | 2.01e-01 | 0.1124 |
5598 | MAPK7 | P21T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.14e-01 | 0.1617 |
5598 | MAPK7 | P22T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.30e-01 | 0.1236 |
5598 | MAPK7 | P23T-E | Human | Esophagus | ESCC | 7.41e-07 | 2.09e-01 | 0.108 |
5598 | MAPK7 | P24T-E | Human | Esophagus | ESCC | 1.47e-03 | 1.10e-01 | 0.1287 |
5598 | MAPK7 | P26T-E | Human | Esophagus | ESCC | 3.62e-03 | 1.25e-01 | 0.1276 |
5598 | MAPK7 | P27T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.04e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:2001236111 | Esophagus | ESCC | regulation of extrinsic apoptotic signaling pathway | 111/8552 | 151/18723 | 2.97e-12 | 1.18e-10 | 111 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:0043618111 | Esophagus | ESCC | regulation of transcription from RNA polymerase II promoter in response to stress | 42/8552 | 47/18723 | 3.91e-10 | 1.05e-08 | 42 |
GO:0043620111 | Esophagus | ESCC | regulation of DNA-templated transcription in response to stress | 46/8552 | 53/18723 | 5.17e-10 | 1.33e-08 | 46 |
GO:0042542111 | Esophagus | ESCC | response to hydrogen peroxide | 102/8552 | 146/18723 | 2.64e-09 | 5.81e-08 | 102 |
GO:0008631110 | Esophagus | ESCC | intrinsic apoptotic signaling pathway in response to oxidative stress | 38/8552 | 45/18723 | 8.42e-08 | 1.43e-06 | 38 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:2001237111 | Esophagus | ESCC | negative regulation of extrinsic apoptotic signaling pathway | 69/8552 | 97/18723 | 3.23e-07 | 4.55e-06 | 69 |
GO:00703018 | Esophagus | ESCC | cellular response to hydrogen peroxide | 68/8552 | 98/18723 | 1.70e-06 | 2.03e-05 | 68 |
GO:00715609 | Esophagus | ESCC | cellular response to transforming growth factor beta stimulus | 151/8552 | 250/18723 | 1.78e-06 | 2.10e-05 | 151 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05418211 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa0465727 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0472225 | Esophagus | ESCC | Neurotrophin signaling pathway | 80/4205 | 119/8465 | 7.33e-05 | 3.07e-04 | 1.57e-04 | 80 |
hsa05418310 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa0465734 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa04722111 | Esophagus | ESCC | Neurotrophin signaling pathway | 80/4205 | 119/8465 | 7.33e-05 | 3.07e-04 | 1.57e-04 | 80 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAPK7 | SNV | Missense_Mutation | novel | c.2090N>T | p.Gly697Val | p.G697V | Q13164 | protein_coding | tolerated(0.08) | benign(0.001) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAPK7 | SNV | Missense_Mutation | novel | c.761A>G | p.Glu254Gly | p.E254G | Q13164 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAPK7 | SNV | Missense_Mutation | c.1258C>T | p.Pro420Ser | p.P420S | Q13164 | protein_coding | deleterious_low_confidence(0.01) | benign(0.011) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MAPK7 | SNV | Missense_Mutation | c.671N>T | p.Thr224Met | p.T224M | Q13164 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAPK7 | SNV | Missense_Mutation | c.2357N>A | p.Gly786Asp | p.G786D | Q13164 | protein_coding | tolerated(0.35) | possibly_damaging(0.656) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MAPK7 | SNV | Missense_Mutation | c.548T>C | p.Leu183Pro | p.L183P | Q13164 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
MAPK7 | SNV | Missense_Mutation | c.1004N>A | p.Arg335His | p.R335H | Q13164 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
MAPK7 | SNV | Missense_Mutation | rs758067983 | c.910N>T | p.Arg304Cys | p.R304C | Q13164 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
MAPK7 | SNV | Missense_Mutation | c.775C>T | p.Arg259Cys | p.R259C | Q13164 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | TG02, SB1317 | |||
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 328083508 | ||
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | sorafenib | SORAFENIB | 20124951 | |
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 249565744 | ||
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 381118893 | ||
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | XMD8-85 | CHEMBL1673039 | 21412406 | |
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 249565737 | ||
5598 | MAPK7 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 328083482 |
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