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Gene: MAP7D2 |
Gene summary for MAP7D2 |
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Gene information | Species | Human | Gene symbol | MAP7D2 | Gene ID | 256714 |
Gene name | MAP7 domain containing 2 | |
Gene Alias | MAP7D2 | |
Cytomap | Xp22.12 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q96T17 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256714 | MAP7D2 | C43 | Human | Oral cavity | OSCC | 2.05e-28 | 6.15e-01 | 0.1704 |
256714 | MAP7D2 | C46 | Human | Oral cavity | OSCC | 3.19e-03 | 8.29e-02 | 0.1673 |
256714 | MAP7D2 | LN22 | Human | Oral cavity | OSCC | 4.06e-06 | 7.92e-01 | 0.1733 |
256714 | MAP7D2 | LN38 | Human | Oral cavity | OSCC | 8.69e-03 | 4.00e-01 | 0.168 |
256714 | MAP7D2 | LN46 | Human | Oral cavity | OSCC | 1.74e-05 | 2.94e-01 | 0.1666 |
256714 | MAP7D2 | SYSMH1 | Human | Oral cavity | OSCC | 5.62e-06 | 1.10e-01 | 0.1127 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP7D2 | SNV | Missense_Mutation | novel | c.665N>A | p.Ser222Tyr | p.S222Y | Q96T17 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP7D2 | SNV | Missense_Mutation | c.591N>G | p.Asp197Glu | p.D197E | Q96T17 | protein_coding | tolerated(0.41) | benign(0.107) | TCGA-AX-A06L-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP7D2 | SNV | Missense_Mutation | c.1963N>G | p.Phe655Val | p.F655V | Q96T17 | protein_coding | tolerated(0.3) | benign(0.259) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP7D2 | SNV | Missense_Mutation | c.1459N>T | p.Arg487Cys | p.R487C | Q96T17 | protein_coding | deleterious(0.04) | benign(0.009) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP7D2 | SNV | Missense_Mutation | novel | c.898N>A | p.Gly300Arg | p.G300R | Q96T17 | protein_coding | tolerated(0.12) | benign(0.318) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MAP7D2 | SNV | Missense_Mutation | novel | c.328N>T | p.Ala110Ser | p.A110S | Q96T17 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MAP7D2 | SNV | Missense_Mutation | novel | c.1967N>A | p.Ser656Tyr | p.S656Y | Q96T17 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MAP7D2 | SNV | Missense_Mutation | novel | c.1555N>A | p.Glu519Lys | p.E519K | Q96T17 | protein_coding | tolerated(0.19) | benign(0.381) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MAP7D2 | SNV | Missense_Mutation | rs747313218 | c.1460N>A | p.Arg487His | p.R487H | Q96T17 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MAP7D2 | SNV | Missense_Mutation | novel | c.821N>A | p.Ser274Tyr | p.S274Y | Q96T17 | protein_coding | tolerated(0.16) | possibly_damaging(0.814) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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