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Gene: MAGEB10 |
Gene summary for MAGEB10 |
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Gene information | Species | Human | Gene symbol | MAGEB10 | Gene ID | 139422 |
Gene name | MAGE family member B10 | |
Gene Alias | MAGEB10 | |
Cytomap | Xp21.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96LZ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
139422 | MAGEB10 | HCC1 | Human | Liver | HCC | 7.19e-14 | 9.30e-01 | 0.5336 |
139422 | MAGEB10 | HCC2 | Human | Liver | HCC | 1.12e-12 | 6.89e-01 | 0.5341 |
139422 | MAGEB10 | HCC5 | Human | Liver | HCC | 1.75e-08 | 8.45e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEB10 | SNV | Missense_Mutation | c.118N>A | p.Pro40Thr | p.P40T | Q96LZ2 | protein_coding | tolerated(0.18) | benign(0.023) | TCGA-85-A53L-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | novel | c.286T>A | p.Cys96Ser | p.C96S | Q96LZ2 | protein_coding | tolerated(1) | benign(0) | TCGA-90-A59Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MAGEB10 | SNV | Missense_Mutation | c.115C>G | p.Pro39Ala | p.P39A | Q96LZ2 | protein_coding | tolerated(0.14) | benign(0.028) | TCGA-94-A4VJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | c.442C>A | p.Gln148Lys | p.Q148K | Q96LZ2 | protein_coding | deleterious(0.01) | benign(0.229) | TCGA-XC-AA0X-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | insertion | Frame_Shift_Ins | novel | c.55_56insT | p.Arg19LeufsTer37 | p.R19Lfs*37 | Q96LZ2 | protein_coding | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MAGEB10 | SNV | Missense_Mutation | novel | c.727G>A | p.Glu243Lys | p.E243K | Q96LZ2 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-BB-4225-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unspecific | SD | |
MAGEB10 | SNV | Missense_Mutation | novel | c.446N>A | p.Phe149Tyr | p.F149Y | Q96LZ2 | protein_coding | deleterious(0.05) | probably_damaging(0.979) | TCGA-CV-7263-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MAGEB10 | SNV | Missense_Mutation | rs761124788 | c.1003N>T | p.Arg335Cys | p.R335C | Q96LZ2 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGEB10 | SNV | Missense_Mutation | c.795C>A | p.Asn265Lys | p.N265K | Q96LZ2 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-D7-8574-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | c.696A>C | p.Leu232Phe | p.L232F | Q96LZ2 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-HU-A4GF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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