![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MAGEA4 |
Gene summary for MAGEA4 |
![]() |
Gene information | Species | Human | Gene symbol | MAGEA4 | Gene ID | 4103 |
Gene name | MAGE family member A4 | |
Gene Alias | CT1.4 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024RC12 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4103 | MAGEA4 | LZE2T | Human | Esophagus | ESCC | 2.05e-21 | 1.78e+00 | 0.082 |
4103 | MAGEA4 | LZE4T | Human | Esophagus | ESCC | 5.68e-07 | 3.08e-01 | 0.0811 |
4103 | MAGEA4 | P1T-E | Human | Esophagus | ESCC | 4.53e-14 | 1.00e+00 | 0.0875 |
4103 | MAGEA4 | P5T-E | Human | Esophagus | ESCC | 2.85e-73 | 1.44e+00 | 0.1327 |
4103 | MAGEA4 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 2.34e-01 | 0.1131 |
4103 | MAGEA4 | P16T-E | Human | Esophagus | ESCC | 2.45e-83 | 1.58e+00 | 0.1153 |
4103 | MAGEA4 | P17T-E | Human | Esophagus | ESCC | 1.45e-12 | 5.97e-01 | 0.1278 |
4103 | MAGEA4 | P24T-E | Human | Esophagus | ESCC | 1.45e-46 | 1.15e+00 | 0.1287 |
4103 | MAGEA4 | P26T-E | Human | Esophagus | ESCC | 1.87e-154 | 3.30e+00 | 0.1276 |
4103 | MAGEA4 | P27T-E | Human | Esophagus | ESCC | 2.06e-59 | 1.17e+00 | 0.1055 |
4103 | MAGEA4 | P28T-E | Human | Esophagus | ESCC | 3.82e-72 | 1.42e+00 | 0.1149 |
4103 | MAGEA4 | P37T-E | Human | Esophagus | ESCC | 2.34e-86 | 2.57e+00 | 0.1371 |
4103 | MAGEA4 | P38T-E | Human | Esophagus | ESCC | 2.41e-07 | 3.32e-01 | 0.127 |
4103 | MAGEA4 | P44T-E | Human | Esophagus | ESCC | 6.29e-05 | 1.90e-01 | 0.1096 |
4103 | MAGEA4 | P47T-E | Human | Esophagus | ESCC | 9.62e-68 | 1.39e+00 | 0.1067 |
4103 | MAGEA4 | P48T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.05e-01 | 0.0959 |
4103 | MAGEA4 | P52T-E | Human | Esophagus | ESCC | 7.28e-26 | 1.26e+00 | 0.1555 |
4103 | MAGEA4 | P54T-E | Human | Esophagus | ESCC | 1.34e-09 | 2.74e-01 | 0.0975 |
4103 | MAGEA4 | P56T-E | Human | Esophagus | ESCC | 3.08e-28 | 2.31e+00 | 0.1613 |
4103 | MAGEA4 | P57T-E | Human | Esophagus | ESCC | 2.86e-20 | 9.54e-01 | 0.0926 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:004578711 | Liver | HCC | positive regulation of cell cycle | 172/7958 | 313/18723 | 5.29e-06 | 6.58e-05 | 172 |
GO:00457879 | Oral cavity | OSCC | positive regulation of cell cycle | 173/7305 | 313/18723 | 3.28e-09 | 7.44e-08 | 173 |
GO:004578717 | Skin | cSCC | positive regulation of cell cycle | 120/4864 | 313/18723 | 8.95e-07 | 1.64e-05 | 120 |
GO:004578719 | Thyroid | ATC | positive regulation of cell cycle | 158/6293 | 313/18723 | 4.18e-10 | 1.14e-08 | 158 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEA4 | SNV | Missense_Mutation | novel | c.160G>A | p.Val54Met | p.V54M | P43358 | protein_coding | deleterious(0.03) | possibly_damaging(0.677) | TCGA-CV-6441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
MAGEA4 | insertion | Frame_Shift_Ins | novel | c.22_23insA | p.His9AlafsTer5 | p.H9Afs*5 | P43358 | protein_coding | TCGA-CV-A45W-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MAGEA4 | SNV | Missense_Mutation | c.895N>T | p.Arg299Cys | p.R299C | P43358 | protein_coding | deleterious(0.02) | possibly_damaging(0.777) | TCGA-KK-A8IA-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | lupron | SD | |
MAGEA4 | SNV | Missense_Mutation | novel | c.142N>A | p.Pro48Thr | p.P48T | P43358 | protein_coding | tolerated(0.23) | benign(0.229) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MAGEA4 | SNV | Missense_Mutation | c.248N>G | p.Gln83Arg | p.Q83R | P43358 | protein_coding | tolerated(0.15) | benign(0.056) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEA4 | SNV | Missense_Mutation | c.704N>A | p.Arg235Lys | p.R235K | P43358 | protein_coding | tolerated(0.38) | benign(0.009) | TCGA-CG-5717-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
MAGEA4 | SNV | Missense_Mutation | c.747N>C | p.Gln249His | p.Q249H | P43358 | protein_coding | tolerated(0.15) | benign(0.139) | TCGA-D7-6527-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
MAGEA4 | SNV | Missense_Mutation | c.731N>T | p.Arg244Met | p.R244M | P43358 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
MAGEA4 | SNV | Missense_Mutation | novel | c.539N>G | p.Val180Gly | p.V180G | P43358 | protein_coding | deleterious(0.02) | probably_damaging(0.912) | TCGA-VQ-A8PC-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4103 | MAGEA4 | NA | CAR-T cells targeting MAGE-A4 |
Page: 1 |