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Gene: LRRN1 |
Gene summary for LRRN1 |
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Gene information | Species | Human | Gene symbol | LRRN1 | Gene ID | 57633 |
Gene name | leucine rich repeat neuronal 1 | |
Gene Alias | FIGLER3 | |
Cytomap | 3p26.2 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q6UXK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57633 | LRRN1 | LZE20T | Human | Esophagus | ESCC | 2.19e-02 | 9.78e-02 | 0.0662 |
57633 | LRRN1 | LZE22T | Human | Esophagus | ESCC | 1.22e-02 | 1.78e-01 | 0.068 |
57633 | LRRN1 | P2T-E | Human | Esophagus | ESCC | 2.15e-21 | 4.49e-01 | 0.1177 |
57633 | LRRN1 | P8T-E | Human | Esophagus | ESCC | 1.02e-19 | 3.04e-01 | 0.0889 |
57633 | LRRN1 | P10T-E | Human | Esophagus | ESCC | 9.10e-08 | 1.12e-01 | 0.116 |
57633 | LRRN1 | P16T-E | Human | Esophagus | ESCC | 1.58e-26 | 5.20e-01 | 0.1153 |
57633 | LRRN1 | P44T-E | Human | Esophagus | ESCC | 1.14e-02 | 7.65e-02 | 0.1096 |
57633 | LRRN1 | P52T-E | Human | Esophagus | ESCC | 3.64e-03 | 8.57e-02 | 0.1555 |
57633 | LRRN1 | P54T-E | Human | Esophagus | ESCC | 1.26e-11 | 3.44e-01 | 0.0975 |
57633 | LRRN1 | P56T-E | Human | Esophagus | ESCC | 1.36e-04 | 6.60e-01 | 0.1613 |
57633 | LRRN1 | P57T-E | Human | Esophagus | ESCC | 4.51e-03 | 7.86e-02 | 0.0926 |
57633 | LRRN1 | P65T-E | Human | Esophagus | ESCC | 1.73e-03 | 1.26e-01 | 0.0978 |
57633 | LRRN1 | P74T-E | Human | Esophagus | ESCC | 1.61e-03 | 9.54e-02 | 0.1479 |
57633 | LRRN1 | P75T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.38e-01 | 0.1125 |
57633 | LRRN1 | P76T-E | Human | Esophagus | ESCC | 8.40e-04 | 6.84e-02 | 0.1207 |
57633 | LRRN1 | P79T-E | Human | Esophagus | ESCC | 9.20e-06 | 7.88e-02 | 0.1154 |
57633 | LRRN1 | P130T-E | Human | Esophagus | ESCC | 2.51e-33 | 5.63e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:190188810 | Esophagus | ESCC | regulation of cell junction assembly | 109/8552 | 204/18723 | 1.53e-02 | 4.96e-02 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRN1 | SNV | Missense_Mutation | novel | c.1532N>C | p.Val511Ala | p.V511A | Q6UXK5 | protein_coding | tolerated(0.07) | possibly_damaging(0.609) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRN1 | SNV | Missense_Mutation | novel | c.446N>G | p.Tyr149Cys | p.Y149C | Q6UXK5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
LRRN1 | SNV | Missense_Mutation | novel | c.325A>G | p.Asn109Asp | p.N109D | Q6UXK5 | protein_coding | tolerated(0.53) | benign(0.037) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRN1 | SNV | Missense_Mutation | c.586C>T | p.Leu196Phe | p.L196F | Q6UXK5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LRRN1 | SNV | Missense_Mutation | novel | c.1709A>G | p.Tyr570Cys | p.Y570C | Q6UXK5 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRN1 | SNV | Missense_Mutation | novel | c.655N>G | p.Ser219Gly | p.S219G | Q6UXK5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRN1 | SNV | Missense_Mutation | rs145715330 | c.1322N>T | p.Thr441Met | p.T441M | Q6UXK5 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRN1 | SNV | Missense_Mutation | rs375458276 | c.109N>A | p.Val37Ile | p.V37I | Q6UXK5 | protein_coding | tolerated(0.08) | probably_damaging(0.992) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRRN1 | SNV | Missense_Mutation | novel | c.1922C>T | p.Ala641Val | p.A641V | Q6UXK5 | protein_coding | tolerated(0.14) | possibly_damaging(0.706) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRRN1 | SNV | Missense_Mutation | novel | c.43N>A | p.Leu15Met | p.L15M | Q6UXK5 | protein_coding | tolerated(0.11) | benign(0.219) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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