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Gene: LEO1 |
Gene summary for LEO1 |
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Gene information | Species | Human | Gene symbol | LEO1 | Gene ID | 123169 |
Gene name | LEO1 homolog, Paf1/RNA polymerase II complex component | |
Gene Alias | RDL | |
Cytomap | 15q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001704 | UniProtAcc | Q8WVC0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123169 | LEO1 | LZE4T | Human | Esophagus | ESCC | 1.30e-14 | 3.79e-01 | 0.0811 |
123169 | LEO1 | LZE6T | Human | Esophagus | ESCC | 3.53e-03 | 1.40e-01 | 0.0845 |
123169 | LEO1 | P1T-E | Human | Esophagus | ESCC | 3.43e-09 | 3.20e-01 | 0.0875 |
123169 | LEO1 | P2T-E | Human | Esophagus | ESCC | 4.19e-15 | 1.75e-01 | 0.1177 |
123169 | LEO1 | P4T-E | Human | Esophagus | ESCC | 4.07e-29 | 6.53e-01 | 0.1323 |
123169 | LEO1 | P5T-E | Human | Esophagus | ESCC | 3.04e-21 | 4.34e-01 | 0.1327 |
123169 | LEO1 | P8T-E | Human | Esophagus | ESCC | 1.55e-23 | 3.95e-01 | 0.0889 |
123169 | LEO1 | P9T-E | Human | Esophagus | ESCC | 1.25e-11 | 2.85e-01 | 0.1131 |
123169 | LEO1 | P10T-E | Human | Esophagus | ESCC | 3.21e-32 | 5.75e-01 | 0.116 |
123169 | LEO1 | P11T-E | Human | Esophagus | ESCC | 2.97e-08 | 1.97e-01 | 0.1426 |
123169 | LEO1 | P12T-E | Human | Esophagus | ESCC | 4.04e-18 | 3.82e-01 | 0.1122 |
123169 | LEO1 | P15T-E | Human | Esophagus | ESCC | 7.49e-18 | 4.15e-01 | 0.1149 |
123169 | LEO1 | P16T-E | Human | Esophagus | ESCC | 1.27e-17 | 3.13e-01 | 0.1153 |
123169 | LEO1 | P19T-E | Human | Esophagus | ESCC | 4.08e-03 | 5.62e-01 | 0.1662 |
123169 | LEO1 | P20T-E | Human | Esophagus | ESCC | 3.83e-11 | 1.56e-01 | 0.1124 |
123169 | LEO1 | P21T-E | Human | Esophagus | ESCC | 2.40e-16 | 2.81e-01 | 0.1617 |
123169 | LEO1 | P22T-E | Human | Esophagus | ESCC | 4.96e-28 | 2.10e-01 | 0.1236 |
123169 | LEO1 | P23T-E | Human | Esophagus | ESCC | 6.02e-14 | 2.83e-01 | 0.108 |
123169 | LEO1 | P24T-E | Human | Esophagus | ESCC | 1.82e-13 | 3.08e-01 | 0.1287 |
123169 | LEO1 | P26T-E | Human | Esophagus | ESCC | 9.26e-18 | 4.18e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:190331316 | Esophagus | ESCC | positive regulation of mRNA metabolic process | 87/8552 | 118/18723 | 5.10e-10 | 1.32e-08 | 87 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:000636814 | Esophagus | ESCC | transcription elongation from RNA polymerase II promoter | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:003278412 | Esophagus | ESCC | regulation of DNA-templated transcription, elongation | 45/8552 | 53/18723 | 3.64e-09 | 7.61e-08 | 45 |
GO:00065136 | Esophagus | ESCC | protein monoubiquitination | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:001657414 | Esophagus | ESCC | histone ubiquitination | 40/8552 | 47/18723 | 2.40e-08 | 4.55e-07 | 40 |
GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
GO:003424312 | Esophagus | ESCC | regulation of transcription elongation from RNA polymerase II promoter | 28/8552 | 32/18723 | 1.02e-06 | 1.29e-05 | 28 |
GO:003112412 | Esophagus | ESCC | mRNA 3'-end processing | 47/8552 | 62/18723 | 1.29e-06 | 1.58e-05 | 47 |
GO:003144013 | Esophagus | ESCC | regulation of mRNA 3'-end processing | 25/8552 | 28/18723 | 1.77e-06 | 2.10e-05 | 25 |
GO:003278613 | Esophagus | ESCC | positive regulation of DNA-templated transcription, elongation | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:00073698 | Esophagus | ESCC | gastrulation | 115/8552 | 185/18723 | 4.35e-06 | 4.64e-05 | 115 |
GO:00103904 | Esophagus | ESCC | histone monoubiquitination | 25/8552 | 29/18723 | 7.24e-06 | 7.20e-05 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LEO1 | SNV | Missense_Mutation | rs751561202 | c.1595G>A | p.Arg532His | p.R532H | Q8WVC0 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LEO1 | insertion | Frame_Shift_Ins | novel | c.1516_1517insCCTATTCA | p.Leu506ProfsTer33 | p.L506Pfs*33 | Q8WVC0 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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