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Gene: KLHL8 |
Gene summary for KLHL8 |
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Gene information | Species | Human | Gene symbol | KLHL8 | Gene ID | 57563 |
Gene name | kelch like family member 8 | |
Gene Alias | KLHL8 | |
Cytomap | 4q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B3KY78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57563 | KLHL8 | HCC1_Meng | Human | Liver | HCC | 3.11e-31 | -6.51e-03 | 0.0246 |
57563 | KLHL8 | HCC2_Meng | Human | Liver | HCC | 1.97e-05 | -8.16e-03 | 0.0107 |
57563 | KLHL8 | HCC2 | Human | Liver | HCC | 3.27e-25 | 3.42e+00 | 0.5341 |
57563 | KLHL8 | HCC5 | Human | Liver | HCC | 6.45e-11 | 9.48e-01 | 0.4932 |
57563 | KLHL8 | S028 | Human | Liver | HCC | 1.71e-07 | 3.63e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL8 | SNV | Missense_Mutation | c.929C>T | p.Thr310Ile | p.T310I | Q9P2G9 | protein_coding | tolerated(0.06) | benign(0.367) | TCGA-D7-6528-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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