![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KIF13A |
Gene summary for KIF13A |
![]() |
Gene information | Species | Human | Gene symbol | KIF13A | Gene ID | 63971 |
Gene name | kinesin family member 13A | |
Gene Alias | RBKIN | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q9H1H9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63971 | KIF13A | CA_HPV_3 | Human | Cervix | CC | 2.92e-05 | 1.59e-01 | 0.0414 |
63971 | KIF13A | CCI_1 | Human | Cervix | CC | 6.31e-18 | 1.50e+00 | 0.528 |
63971 | KIF13A | CCI_2 | Human | Cervix | CC | 5.84e-07 | 9.87e-01 | 0.5249 |
63971 | KIF13A | CCI_3 | Human | Cervix | CC | 1.06e-08 | 8.33e-01 | 0.516 |
63971 | KIF13A | sample3 | Human | Cervix | CC | 9.09e-03 | 1.23e-01 | 0.1387 |
63971 | KIF13A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.33e-08 | -3.20e-01 | 0.0155 |
63971 | KIF13A | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.55e-03 | 4.77e-01 | -0.0811 |
63971 | KIF13A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.66e-14 | 8.27e-01 | -0.1954 |
63971 | KIF13A | HTA11_411_2000001011 | Human | Colorectum | SER | 2.39e-02 | 6.16e-01 | -0.2602 |
63971 | KIF13A | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.79e-04 | 6.58e-01 | -0.059 |
63971 | KIF13A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.18e-09 | -4.01e-01 | 0.294 |
63971 | KIF13A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.58e-03 | 4.72e-01 | 0.281 |
63971 | KIF13A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.34e-43 | -7.55e-01 | 0.3005 |
63971 | KIF13A | F007 | Human | Colorectum | FAP | 4.02e-03 | -3.47e-01 | 0.1176 |
63971 | KIF13A | A002-C-010 | Human | Colorectum | FAP | 3.07e-05 | 1.43e-01 | 0.242 |
63971 | KIF13A | A015-C-203 | Human | Colorectum | FAP | 4.99e-40 | -6.55e-01 | -0.1294 |
63971 | KIF13A | A015-C-204 | Human | Colorectum | FAP | 5.49e-05 | -4.33e-01 | -0.0228 |
63971 | KIF13A | A014-C-040 | Human | Colorectum | FAP | 2.65e-02 | -2.40e-01 | -0.1184 |
63971 | KIF13A | A002-C-201 | Human | Colorectum | FAP | 1.15e-08 | -3.39e-01 | 0.0324 |
63971 | KIF13A | A001-C-119 | Human | Colorectum | FAP | 2.91e-06 | -4.48e-01 | -0.1557 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00068927 | Cervix | CC | post-Golgi vesicle-mediated transport | 28/2311 | 104/18723 | 4.31e-05 | 6.61e-04 | 28 |
GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
GO:00513021 | Cervix | CC | regulation of cell division | 39/2311 | 177/18723 | 2.05e-04 | 2.33e-03 | 39 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:00009107 | Cervix | CC | cytokinesis | 37/2311 | 173/18723 | 5.40e-04 | 5.23e-03 | 37 |
GO:00070347 | Cervix | CC | vacuolar transport | 34/2311 | 157/18723 | 7.03e-04 | 6.40e-03 | 34 |
GO:00307057 | Cervix | CC | cytoskeleton-dependent intracellular transport | 40/2311 | 195/18723 | 7.92e-04 | 6.99e-03 | 40 |
GO:0032465 | Cervix | CC | regulation of cytokinesis | 22/2311 | 92/18723 | 1.55e-03 | 1.20e-02 | 22 |
GO:00068936 | Cervix | CC | Golgi to plasma membrane transport | 16/2311 | 60/18723 | 2.00e-03 | 1.46e-02 | 16 |
GO:00619516 | Cervix | CC | establishment of protein localization to plasma membrane | 16/2311 | 60/18723 | 2.00e-03 | 1.46e-02 | 16 |
GO:00430016 | Cervix | CC | Golgi to plasma membrane protein transport | 12/2311 | 40/18723 | 2.44e-03 | 1.71e-02 | 12 |
GO:00160506 | Cervix | CC | vesicle organization | 54/2311 | 300/18723 | 2.71e-03 | 1.85e-02 | 54 |
GO:00070416 | Cervix | CC | lysosomal transport | 24/2311 | 114/18723 | 5.81e-03 | 3.33e-02 | 24 |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04814 | Lung | MIAC | Motor proteins | 21/507 | 193/8465 | 5.64e-03 | 3.82e-02 | 2.76e-02 | 21 |
hsa048141 | Lung | MIAC | Motor proteins | 21/507 | 193/8465 | 5.64e-03 | 3.82e-02 | 2.76e-02 | 21 |
hsa048145 | Oral cavity | NEOLP | Motor proteins | 37/1112 | 193/8465 | 1.06e-02 | 3.54e-02 | 2.22e-02 | 37 |
hsa0481412 | Oral cavity | NEOLP | Motor proteins | 37/1112 | 193/8465 | 1.06e-02 | 3.54e-02 | 2.22e-02 | 37 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF13A | SNV | Missense_Mutation | c.3827N>T | p.Ala1276Val | p.A1276V | Q9H1H9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIF13A | SNV | Missense_Mutation | c.1331N>G | p.Asp444Gly | p.D444G | Q9H1H9 | protein_coding | tolerated(0.07) | benign(0.084) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIF13A | SNV | Missense_Mutation | c.4623N>T | p.Arg1541Ser | p.R1541S | Q9H1H9 | protein_coding | tolerated_low_confidence(0.19) | benign(0.009) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIF13A | SNV | Missense_Mutation | c.4069N>A | p.Leu1357Met | p.L1357M | Q9H1H9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIF13A | SNV | Missense_Mutation | c.790N>A | p.Ala264Thr | p.A264T | Q9H1H9 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-CL-4957-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
KIF13A | deletion | Frame_Shift_Del | c.1617delN | p.Phe539LeufsTer3 | p.F539Lfs*3 | Q9H1H9 | protein_coding | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |||
KIF13A | insertion | Frame_Shift_Ins | novel | c.3345dupA | p.Val1116SerfsTer4 | p.V1116Sfs*4 | Q9H1H9 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
KIF13A | deletion | Frame_Shift_Del | c.2325delN | p.Lys775AsnfsTer30 | p.K775Nfs*30 | Q9H1H9 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
KIF13A | deletion | Frame_Shift_Del | c.1617delT | p.Phe539LeufsTer3 | p.F539Lfs*3 | Q9H1H9 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
KIF13A | insertion | Frame_Shift_Ins | novel | c.3345_3346insA | p.Val1116SerfsTer4 | p.V1116Sfs*4 | Q9H1H9 | protein_coding | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |