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Gene: KIAA2026 |
Gene summary for KIAA2026 |
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Gene information | Species | Human | Gene symbol | KIAA2026 | Gene ID | 158358 |
Gene name | KIAA2026 | |
Gene Alias | KIAA2026 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5HYC2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158358 | KIAA2026 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.98e-25 | -6.81e-01 | 0.0155 |
158358 | KIAA2026 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.18e-02 | -3.61e-01 | -0.1808 |
158358 | KIAA2026 | HTA11_2951_2000001011 | Human | Colorectum | AD | 7.33e-03 | -6.86e-01 | 0.0216 |
158358 | KIAA2026 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.62e-11 | -6.84e-01 | -0.1207 |
158358 | KIAA2026 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.24e-02 | -3.24e-01 | -0.1526 |
158358 | KIAA2026 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.69e-12 | -4.54e-01 | -0.1464 |
158358 | KIAA2026 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.85e-09 | -4.59e-01 | -0.1001 |
158358 | KIAA2026 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.08e-06 | -3.85e-01 | -0.059 |
158358 | KIAA2026 | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.95e-03 | -5.19e-01 | -0.1462 |
158358 | KIAA2026 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.14e-04 | -4.80e-01 | -0.0842 |
158358 | KIAA2026 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.32e-02 | -5.70e-01 | -0.0179 |
158358 | KIAA2026 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.47e-18 | -6.69e-01 | 0.096 |
158358 | KIAA2026 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.44e-03 | -5.82e-01 | 0.0528 |
158358 | KIAA2026 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.88e-02 | -6.39e-01 | 0.0171 |
158358 | KIAA2026 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.25e-08 | -5.97e-01 | 0.0338 |
158358 | KIAA2026 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.45e-13 | -5.10e-01 | 0.0674 |
158358 | KIAA2026 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.35e-07 | -5.00e-01 | 0.0588 |
158358 | KIAA2026 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.96e-15 | -4.54e-01 | 0.294 |
158358 | KIAA2026 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.69e-09 | -4.35e-01 | 0.3859 |
158358 | KIAA2026 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.67e-08 | -6.67e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA2026 | SNV | Missense_Mutation | rs754732111 | c.4241N>T | p.Ser1414Leu | p.S1414L | Q5HYC2 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
KIAA2026 | SNV | Missense_Mutation | c.3841N>A | p.Leu1281Ile | p.L1281I | Q5HYC2 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIAA2026 | SNV | Missense_Mutation | c.2398N>T | p.Arg800Trp | p.R800W | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIAA2026 | SNV | Missense_Mutation | c.1720N>T | p.Arg574Cys | p.R574C | Q5HYC2 | protein_coding | tolerated(0.07) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIAA2026 | deletion | Frame_Shift_Del | novel | c.793delN | p.Arg265GlyfsTer18 | p.R265Gfs*18 | Q5HYC2 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
KIAA2026 | deletion | Frame_Shift_Del | novel | c.320delG | p.Gly107AlafsTer57 | p.G107Afs*57 | Q5HYC2 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
KIAA2026 | deletion | Frame_Shift_Del | rs780877908 | c.2187delN | p.Ala730GlnfsTer26 | p.A730Qfs*26 | Q5HYC2 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KIAA2026 | insertion | In_Frame_Ins | novel | c.4201_4202insACAGGGTAACTT | p.Ile1401delinsAsnArgValThrPhe | p.I1401delinsNRVTF | Q5HYC2 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA2026 | insertion | Nonsense_Mutation | novel | c.3341_3342insCAAAAACTGATGC | p.Glu1116AsnfsTer2 | p.E1116Nfs*2 | Q5HYC2 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA2026 | insertion | Frame_Shift_Ins | novel | c.3047_3048insCCATTTG | p.Lys1017HisfsTer3 | p.K1017Hfs*3 | Q5HYC2 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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