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Gene: KIAA1522 |
Gene summary for KIAA1522 |
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Gene information | Species | Human | Gene symbol | KIAA1522 | Gene ID | 57648 |
Gene name | KIAA1522 | |
Gene Alias | KIAA1522 | |
Cytomap | 1p35.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9P206 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57648 | KIAA1522 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.18e-03 | 9.01e-02 | 0.0155 |
57648 | KIAA1522 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.68e-21 | 9.67e-01 | -0.1808 |
57648 | KIAA1522 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.34e-14 | 8.12e-01 | -0.0811 |
57648 | KIAA1522 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.50e-09 | 7.06e-01 | -0.1088 |
57648 | KIAA1522 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.38e-35 | 1.03e+00 | -0.1954 |
57648 | KIAA1522 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.37e-10 | 1.50e+00 | -0.2602 |
57648 | KIAA1522 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.31e-07 | 1.13e+00 | -0.2196 |
57648 | KIAA1522 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.20e-05 | 5.72e-01 | -0.1207 |
57648 | KIAA1522 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.32e-12 | 8.56e-01 | -0.1526 |
57648 | KIAA1522 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.56e-22 | 9.31e-01 | -0.1464 |
57648 | KIAA1522 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.19e-12 | 6.72e-01 | -0.1001 |
57648 | KIAA1522 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.78e-19 | 1.01e+00 | -0.059 |
57648 | KIAA1522 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.27e-07 | 9.26e-01 | -0.1706 |
57648 | KIAA1522 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.15e-02 | 5.92e-01 | -0.1462 |
57648 | KIAA1522 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.06e-06 | 6.68e-01 | -0.0842 |
57648 | KIAA1522 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.83e-02 | 5.33e-01 | -0.0179 |
57648 | KIAA1522 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.88e-05 | 4.08e-01 | 0.096 |
57648 | KIAA1522 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.51e-03 | 7.19e-01 | 0.0131 |
57648 | KIAA1522 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.75e-05 | 8.14e-01 | -0.0177 |
57648 | KIAA1522 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.20e-04 | 8.05e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1522 | SNV | Missense_Mutation | c.893G>T | p.Arg298Leu | p.R298L | Q9P206 | protein_coding | tolerated(0.08) | probably_damaging(0.926) | TCGA-RC-A7SF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KIAA1522 | SNV | Missense_Mutation | c.529G>A | p.Glu177Lys | p.E177K | Q9P206 | protein_coding | tolerated(0.09) | probably_damaging(0.941) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA1522 | SNV | Missense_Mutation | c.2695C>T | p.Pro899Ser | p.P899S | Q9P206 | protein_coding | tolerated(0.31) | benign(0.001) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KIAA1522 | SNV | Missense_Mutation | novel | c.1363C>A | p.Pro455Thr | p.P455T | Q9P206 | protein_coding | tolerated(0.11) | benign(0.009) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
KIAA1522 | SNV | Missense_Mutation | novel | c.734N>A | p.Pro245His | p.P245H | Q9P206 | protein_coding | tolerated(0.06) | probably_damaging(0.947) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1522 | SNV | Missense_Mutation | rs765046369 | c.1325N>T | p.Pro442Leu | p.P442L | Q9P206 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
KIAA1522 | SNV | Missense_Mutation | rs745962997 | c.3148N>T | p.Pro1050Ser | p.P1050S | Q9P206 | protein_coding | deleterious_low_confidence(0.05) | benign(0.135) | TCGA-91-7771-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
KIAA1522 | SNV | Missense_Mutation | rs776125780 | c.2717N>T | p.Ser906Leu | p.S906L | Q9P206 | protein_coding | tolerated(0.11) | benign(0) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA1522 | SNV | Missense_Mutation | c.3127C>G | p.Arg1043Gly | p.R1043G | Q9P206 | protein_coding | tolerated_low_confidence(0.27) | benign(0.003) | TCGA-95-7947-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KIAA1522 | SNV | Missense_Mutation | novel | c.541N>A | p.Ala181Thr | p.A181T | Q9P206 | protein_coding | tolerated(0.21) | benign(0.198) | TCGA-99-8033-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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