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Gene: KIAA0368 |
Gene summary for KIAA0368 |
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Gene information | Species | Human | Gene symbol | KIAA0368 | Gene ID | 23392 |
Gene name | Ecm29 proteasome adaptor and scaffold | |
Gene Alias | ECM29 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23392 | KIAA0368 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.12e-43 | 7.58e-01 | 0.294 |
23392 | KIAA0368 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.11e-13 | 1.58e+00 | 0.3487 |
23392 | KIAA0368 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.99e-33 | 8.59e-01 | 0.281 |
23392 | KIAA0368 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.49e-45 | 7.91e-01 | 0.3859 |
23392 | KIAA0368 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.57e-07 | 3.35e-01 | 0.2585 |
23392 | KIAA0368 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.63e-19 | 3.75e-01 | 0.3005 |
23392 | KIAA0368 | P1T-E | Human | Esophagus | ESCC | 7.20e-08 | 4.51e-01 | 0.0875 |
23392 | KIAA0368 | P2T-E | Human | Esophagus | ESCC | 3.16e-29 | 5.26e-01 | 0.1177 |
23392 | KIAA0368 | P4T-E | Human | Esophagus | ESCC | 1.46e-07 | 1.30e-01 | 0.1323 |
23392 | KIAA0368 | P5T-E | Human | Esophagus | ESCC | 9.20e-21 | 3.54e-01 | 0.1327 |
23392 | KIAA0368 | P8T-E | Human | Esophagus | ESCC | 7.74e-14 | 1.66e-01 | 0.0889 |
23392 | KIAA0368 | P9T-E | Human | Esophagus | ESCC | 1.01e-08 | 2.07e-01 | 0.1131 |
23392 | KIAA0368 | P10T-E | Human | Esophagus | ESCC | 2.43e-15 | 2.04e-01 | 0.116 |
23392 | KIAA0368 | P11T-E | Human | Esophagus | ESCC | 6.82e-04 | 3.29e-01 | 0.1426 |
23392 | KIAA0368 | P12T-E | Human | Esophagus | ESCC | 3.11e-14 | 2.03e-01 | 0.1122 |
23392 | KIAA0368 | P15T-E | Human | Esophagus | ESCC | 4.38e-13 | 2.99e-01 | 0.1149 |
23392 | KIAA0368 | P16T-E | Human | Esophagus | ESCC | 2.52e-12 | 9.17e-02 | 0.1153 |
23392 | KIAA0368 | P17T-E | Human | Esophagus | ESCC | 2.28e-07 | 4.24e-01 | 0.1278 |
23392 | KIAA0368 | P19T-E | Human | Esophagus | ESCC | 3.64e-02 | 3.70e-01 | 0.1662 |
23392 | KIAA0368 | P20T-E | Human | Esophagus | ESCC | 1.14e-11 | 8.94e-02 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0368 | SNV | Missense_Mutation | novel | c.3569N>C | p.Glu1190Ala | p.E1190A | protein_coding | tolerated(0.13) | benign(0.124) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
KIAA0368 | SNV | Missense_Mutation | novel | c.5998N>T | p.Pro2000Ser | p.P2000S | protein_coding | deleterious(0.03) | possibly_damaging(0.798) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
KIAA0368 | SNV | Missense_Mutation | rs747003887 | c.4546N>G | p.Ile1516Val | p.I1516V | protein_coding | tolerated(0.97) | benign(0.02) | TCGA-AX-A2IN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KIAA0368 | SNV | Missense_Mutation | rs200488483 | c.5056N>A | p.Val1686Ile | p.V1686I | protein_coding | deleterious(0.02) | benign(0.045) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
KIAA0368 | SNV | Missense_Mutation | c.6030N>T | p.Lys2010Asn | p.K2010N | protein_coding | deleterious(0.01) | benign(0.248) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA0368 | SNV | Missense_Mutation | c.3539N>A | p.Gly1180Asp | p.G1180D | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA0368 | SNV | Missense_Mutation | c.1247N>C | p.Lys416Thr | p.K416T | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA0368 | SNV | Missense_Mutation | novel | c.3452N>C | p.Val1151Ala | p.V1151A | protein_coding | deleterious(0) | benign(0.381) | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KIAA0368 | SNV | Missense_Mutation | novel | c.3482N>T | p.Ala1161Val | p.A1161V | protein_coding | tolerated(0.06) | possibly_damaging(0.644) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
KIAA0368 | SNV | Missense_Mutation | novel | c.4909G>A | p.Ala1637Thr | p.A1637T | protein_coding | deleterious(0.01) | possibly_damaging(0.899) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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