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Gene: KCTD3 |
Gene summary for KCTD3 |
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Gene information | Species | Human | Gene symbol | KCTD3 | Gene ID | 51133 |
Gene name | potassium channel tetramerization domain containing 3 | |
Gene Alias | NY-REN-45 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9Y597 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51133 | KCTD3 | GSM4909298 | Human | Breast | IDC | 3.98e-14 | 3.47e-01 | 0.1551 |
51133 | KCTD3 | GSM4909308 | Human | Breast | IDC | 1.40e-05 | 2.72e-01 | 0.158 |
51133 | KCTD3 | GSM4909311 | Human | Breast | IDC | 7.05e-06 | -1.19e-01 | 0.1534 |
51133 | KCTD3 | GSM4909319 | Human | Breast | IDC | 2.63e-06 | -7.90e-02 | 0.1563 |
51133 | KCTD3 | M5 | Human | Breast | IDC | 2.25e-03 | 6.24e-01 | 0.1598 |
51133 | KCTD3 | NCCBC14 | Human | Breast | DCIS | 9.01e-05 | 3.87e-01 | 0.2021 |
51133 | KCTD3 | DCIS2 | Human | Breast | DCIS | 1.55e-65 | 4.03e-01 | 0.0085 |
51133 | KCTD3 | CCI_1 | Human | Cervix | CC | 1.92e-06 | 6.35e-01 | 0.528 |
51133 | KCTD3 | CCI_3 | Human | Cervix | CC | 2.38e-13 | 6.97e-01 | 0.516 |
51133 | KCTD3 | LZE2T | Human | Esophagus | ESCC | 2.08e-04 | 5.14e-01 | 0.082 |
51133 | KCTD3 | LZE7T | Human | Esophagus | ESCC | 4.96e-03 | 2.41e-01 | 0.0667 |
51133 | KCTD3 | P1T-E | Human | Esophagus | ESCC | 5.49e-05 | 3.38e-01 | 0.0875 |
51133 | KCTD3 | P2T-E | Human | Esophagus | ESCC | 4.48e-29 | 2.28e-01 | 0.1177 |
51133 | KCTD3 | P5T-E | Human | Esophagus | ESCC | 7.23e-15 | 1.68e-01 | 0.1327 |
51133 | KCTD3 | P8T-E | Human | Esophagus | ESCC | 3.87e-10 | 1.75e-01 | 0.0889 |
51133 | KCTD3 | P9T-E | Human | Esophagus | ESCC | 6.63e-09 | 1.78e-01 | 0.1131 |
51133 | KCTD3 | P10T-E | Human | Esophagus | ESCC | 1.61e-15 | 1.51e-01 | 0.116 |
51133 | KCTD3 | P11T-E | Human | Esophagus | ESCC | 8.91e-05 | 2.95e-01 | 0.1426 |
51133 | KCTD3 | P12T-E | Human | Esophagus | ESCC | 2.46e-17 | 1.40e-01 | 0.1122 |
51133 | KCTD3 | P15T-E | Human | Esophagus | ESCC | 3.36e-06 | 1.91e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:0051259 | Oral cavity | OSCC | protein complex oligomerization | 121/7305 | 238/18723 | 1.29e-04 | 9.21e-04 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCTD3 | SNV | Missense_Mutation | novel | c.1899N>T | p.Gln633His | p.Q633H | Q9Y597 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.854) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
KCTD3 | SNV | Missense_Mutation | rs747807604 | c.1578N>T | p.Gln526His | p.Q526H | Q9Y597 | protein_coding | tolerated(0.08) | benign(0.213) | TCGA-50-5942-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KCTD3 | SNV | Missense_Mutation | c.137N>T | p.Ser46Ile | p.S46I | Q9Y597 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
KCTD3 | SNV | Missense_Mutation | c.1021G>C | p.Asp341His | p.D341H | Q9Y597 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCTD3 | SNV | Missense_Mutation | c.904N>T | p.Val302Leu | p.V302L | Q9Y597 | protein_coding | deleterious(0) | possibly_damaging(0.608) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
KCTD3 | SNV | Missense_Mutation | c.2216N>G | p.Lys739Arg | p.K739R | Q9Y597 | protein_coding | tolerated_low_confidence(0.31) | benign(0) | TCGA-62-A471-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
KCTD3 | SNV | Missense_Mutation | c.1974N>C | p.Arg658Ser | p.R658S | Q9Y597 | protein_coding | deleterious_low_confidence(0.01) | benign(0.104) | TCGA-91-6829-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KCTD3 | SNV | Missense_Mutation | novel | c.2050G>C | p.Val684Leu | p.V684L | Q9Y597 | protein_coding | tolerated_low_confidence(0.24) | benign(0) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCTD3 | SNV | Missense_Mutation | novel | c.2261N>T | p.Arg754Met | p.R754M | Q9Y597 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.466) | TCGA-L9-A5IP-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KCTD3 | SNV | Missense_Mutation | c.114N>T | p.Trp38Cys | p.W38C | Q9Y597 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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