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Gene: IQCA1 |
Gene summary for IQCA1 |
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Gene information | Species | Human | Gene symbol | IQCA1 | Gene ID | 79781 |
Gene name | IQ motif containing with AAA domain 1 | |
Gene Alias | 4930465P12Rik | |
Cytomap | 2q37.2-q37.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86XH1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79781 | IQCA1 | LZE4T | Human | Esophagus | ESCC | 9.10e-05 | 2.53e-01 | 0.0811 |
79781 | IQCA1 | LZE24T | Human | Esophagus | ESCC | 7.90e-10 | 3.12e-01 | 0.0596 |
79781 | IQCA1 | P2T-E | Human | Esophagus | ESCC | 1.33e-07 | 1.92e-01 | 0.1177 |
79781 | IQCA1 | P4T-E | Human | Esophagus | ESCC | 3.10e-10 | 2.62e-01 | 0.1323 |
79781 | IQCA1 | P5T-E | Human | Esophagus | ESCC | 9.20e-11 | 1.57e-01 | 0.1327 |
79781 | IQCA1 | P8T-E | Human | Esophagus | ESCC | 5.17e-11 | 1.96e-01 | 0.0889 |
79781 | IQCA1 | P10T-E | Human | Esophagus | ESCC | 9.07e-22 | 3.45e-01 | 0.116 |
79781 | IQCA1 | P11T-E | Human | Esophagus | ESCC | 3.13e-05 | 2.34e-01 | 0.1426 |
79781 | IQCA1 | P12T-E | Human | Esophagus | ESCC | 3.48e-52 | 1.00e+00 | 0.1122 |
79781 | IQCA1 | P15T-E | Human | Esophagus | ESCC | 5.28e-09 | 2.67e-01 | 0.1149 |
79781 | IQCA1 | P16T-E | Human | Esophagus | ESCC | 3.72e-13 | 3.37e-01 | 0.1153 |
79781 | IQCA1 | P21T-E | Human | Esophagus | ESCC | 5.11e-06 | 1.41e-01 | 0.1617 |
79781 | IQCA1 | P27T-E | Human | Esophagus | ESCC | 5.56e-35 | 6.51e-01 | 0.1055 |
79781 | IQCA1 | P28T-E | Human | Esophagus | ESCC | 6.37e-07 | 8.25e-02 | 0.1149 |
79781 | IQCA1 | P30T-E | Human | Esophagus | ESCC | 6.20e-13 | 4.54e-01 | 0.137 |
79781 | IQCA1 | P32T-E | Human | Esophagus | ESCC | 1.50e-16 | 3.10e-01 | 0.1666 |
79781 | IQCA1 | P39T-E | Human | Esophagus | ESCC | 1.81e-07 | 1.24e-01 | 0.0894 |
79781 | IQCA1 | P40T-E | Human | Esophagus | ESCC | 1.23e-03 | 1.95e-01 | 0.109 |
79781 | IQCA1 | P42T-E | Human | Esophagus | ESCC | 4.31e-05 | 2.09e-01 | 0.1175 |
79781 | IQCA1 | P48T-E | Human | Esophagus | ESCC | 1.73e-09 | 2.36e-01 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IQCA1 | SNV | Missense_Mutation | rs765152475 | c.2348C>T | p.Ala783Val | p.A783V | protein_coding | tolerated(0.26) | benign(0.048) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IQCA1 | SNV | Missense_Mutation | novel | c.1398N>T | p.Arg466Ser | p.R466S | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
IQCA1 | SNV | Missense_Mutation | novel | c.77N>A | p.Ala26Asp | p.A26D | protein_coding | tolerated(0.65) | benign(0) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
IQCA1 | SNV | Missense_Mutation | rs374268870 | c.2302C>T | p.Arg768Trp | p.R768W | protein_coding | tolerated(0.17) | possibly_damaging(0.786) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
IQCA1 | SNV | Missense_Mutation | rs746688702 | c.2045N>A | p.Arg682Gln | p.R682Q | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IQCA1 | SNV | Missense_Mutation | c.1648N>A | p.Leu550Met | p.L550M | protein_coding | tolerated(0.22) | benign(0.025) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IQCA1 | SNV | Missense_Mutation | rs765152475 | c.2348C>T | p.Ala783Val | p.A783V | protein_coding | tolerated(0.26) | benign(0.048) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IQCA1 | SNV | Missense_Mutation | novel | c.1055A>G | p.Asn352Ser | p.N352S | protein_coding | tolerated(0.46) | benign(0) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IQCA1 | SNV | Missense_Mutation | novel | c.57G>T | p.Gln19His | p.Q19H | protein_coding | deleterious(0.02) | benign(0.396) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IQCA1 | SNV | Missense_Mutation | novel | c.1001N>T | p.Ala334Val | p.A334V | protein_coding | tolerated(0.39) | possibly_damaging(0.503) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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