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Gene: IGSF11 |
Gene summary for IGSF11 |
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Gene information | Species | Human | Gene symbol | IGSF11 | Gene ID | 152404 |
Gene name | immunoglobulin superfamily member 11 | |
Gene Alias | BT-IgSF | |
Cytomap | 3q13.32 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q5DX21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152404 | IGSF11 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.17e-02 | 6.69e-01 | -0.2602 |
152404 | IGSF11 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.26e-04 | 3.87e-01 | -0.1526 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00451851 | Colorectum | SER | maintenance of protein location | 26/2897 | 94/18723 | 1.76e-03 | 1.81e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGSF11 | SNV | Missense_Mutation | c.180G>T | p.Met60Ile | p.M60I | Q5DX21 | protein_coding | tolerated(0.07) | possibly_damaging(0.874) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | rs753373347 | c.100N>A | p.Val34Met | p.V34M | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-77-8156-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | novel | c.1166A>G | p.Asn389Ser | p.N389S | Q5DX21 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-85-8288-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | novel | c.932N>C | p.Leu311Pro | p.L311P | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-92-8063-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | taxol | SD |
IGSF11 | SNV | Missense_Mutation | c.177G>T | p.Trp59Cys | p.W59C | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-94-A4VJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | novel | c.1023G>T | p.Leu341Phe | p.L341F | Q5DX21 | protein_coding | tolerated(0.74) | benign(0.271) | TCGA-96-A4JK-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR |
IGSF11 | insertion | Frame_Shift_Ins | novel | c.770_771insT | p.Ile258HisfsTer16 | p.I258Hfs*16 | Q5DX21 | protein_coding | TCGA-95-7947-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
IGSF11 | insertion | Frame_Shift_Ins | novel | c.769_770insT | p.Cys257LeufsTer17 | p.C257Lfs*17 | Q5DX21 | protein_coding | TCGA-MP-A4SY-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
IGSF11 | SNV | Missense_Mutation | novel | c.768T>A | p.Phe256Leu | p.F256L | Q5DX21 | protein_coding | tolerated(0.48) | benign(0) | TCGA-CV-6962-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | novel | c.1022T>G | p.Leu341Trp | p.L341W | Q5DX21 | protein_coding | tolerated(0.19) | possibly_damaging(0.71) | TCGA-CV-7446-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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