GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199077818 | Esophagus | HGIN | protein localization to cell periphery | 71/2587 | 333/18723 | 1.05e-04 | 2.24e-03 | 71 |
GO:000164917 | Esophagus | HGIN | osteoblast differentiation | 50/2587 | 229/18723 | 5.88e-04 | 8.30e-03 | 50 |
GO:003011116 | Esophagus | HGIN | regulation of Wnt signaling pathway | 65/2587 | 328/18723 | 1.53e-03 | 1.77e-02 | 65 |
GO:001605516 | Esophagus | HGIN | Wnt signaling pathway | 83/2587 | 444/18723 | 2.27e-03 | 2.33e-02 | 83 |
GO:019873816 | Esophagus | HGIN | cell-cell signaling by wnt | 83/2587 | 446/18723 | 2.58e-03 | 2.55e-02 | 83 |
GO:000150316 | Esophagus | HGIN | ossification | 75/2587 | 408/18723 | 5.49e-03 | 4.49e-02 | 75 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:00603485 | Esophagus | ESCC | bone development | 115/8552 | 205/18723 | 1.67e-03 | 7.72e-03 | 115 |
GO:00301788 | Esophagus | ESCC | negative regulation of Wnt signaling pathway | 97/8552 | 170/18723 | 1.81e-03 | 8.31e-03 | 97 |
GO:00487367 | Esophagus | ESCC | appendage development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00601737 | Esophagus | ESCC | limb development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00355671 | Esophagus | ESCC | non-canonical Wnt signaling pathway | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:19055153 | Esophagus | ESCC | non-motile cilium assembly | 39/8552 | 61/18723 | 3.08e-03 | 1.28e-02 | 39 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFT80 | SNV | Missense_Mutation | novel | c.42N>C | p.Gln14His | p.Q14H | Q9P2H3 | protein_coding | tolerated(0.14) | benign(0.212) | TCGA-DD-AAE7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IFT80 | SNV | Missense_Mutation | novel | c.227N>T | p.Gln76Leu | p.Q76L | Q9P2H3 | protein_coding | tolerated(0.28) | benign(0.086) | TCGA-86-A456-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFT80 | SNV | Missense_Mutation | novel | c.2011N>T | p.Asn671Tyr | p.N671Y | Q9P2H3 | protein_coding | deleterious(0.01) | benign(0.086) | TCGA-33-A5GW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IFT80 | SNV | Missense_Mutation | novel | c.1214N>T | p.Ser405Leu | p.S405L | Q9P2H3 | protein_coding | deleterious(0.04) | benign(0.335) | TCGA-34-2605-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
IFT80 | SNV | Missense_Mutation | | c.2005N>C | p.Ser669Arg | p.S669R | Q9P2H3 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-43-3394-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | PD |
IFT80 | SNV | Missense_Mutation | novel | c.2137N>A | p.Asp713Asn | p.D713N | Q9P2H3 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-56-A4BW-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
IFT80 | SNV | Missense_Mutation | | c.1159N>A | p.Leu387Ile | p.L387I | Q9P2H3 | protein_coding | tolerated(0.11) | benign(0.265) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IFT80 | SNV | Missense_Mutation | novel | c.1274N>A | p.Ser425Asn | p.S425N | Q9P2H3 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IFT80 | SNV | Missense_Mutation | rs148396265 | c.1229N>T | p.Pro410Leu | p.P410L | Q9P2H3 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-60-2706-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IFT80 | SNV | Missense_Mutation | | c.932N>G | p.Thr311Arg | p.T311R | Q9P2H3 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-60-2722-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD |