![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HNF4G |
Gene summary for HNF4G |
![]() |
Gene information | Species | Human | Gene symbol | HNF4G | Gene ID | 3174 |
Gene name | hepatocyte nuclear factor 4 gamma | |
Gene Alias | NR2A2 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q14541 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3174 | HNF4G | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.64e-42 | -8.82e-01 | 0.0155 |
3174 | HNF4G | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.09e-02 | -6.84e-01 | 0.0216 |
3174 | HNF4G | HTA11_347_2000001011 | Human | Colorectum | AD | 3.61e-08 | 6.08e-01 | -0.1954 |
3174 | HNF4G | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.04e-12 | -7.00e-01 | -0.1207 |
3174 | HNF4G | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.34e-03 | -4.38e-01 | -0.2061 |
3174 | HNF4G | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.65e-04 | -5.52e-01 | -0.0179 |
3174 | HNF4G | HTA11_866_3004761011 | Human | Colorectum | AD | 5.51e-25 | -6.74e-01 | 0.096 |
3174 | HNF4G | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.08e-03 | -8.41e-01 | 0.0451 |
3174 | HNF4G | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.03e-06 | -6.37e-01 | 0.0528 |
3174 | HNF4G | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.57e-08 | -5.60e-01 | 0.0338 |
3174 | HNF4G | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.17e-10 | -5.38e-01 | 0.0674 |
3174 | HNF4G | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.40e-09 | -6.43e-01 | 0.0588 |
3174 | HNF4G | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.50e-36 | -8.50e-01 | 0.294 |
3174 | HNF4G | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.53e-05 | -4.10e-01 | 0.3859 |
3174 | HNF4G | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.21e-16 | -8.85e-01 | 0.2585 |
3174 | HNF4G | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.03e-28 | -7.22e-01 | 0.3005 |
3174 | HNF4G | F007 | Human | Colorectum | FAP | 2.33e-07 | -5.07e-01 | 0.1176 |
3174 | HNF4G | A001-C-207 | Human | Colorectum | FAP | 3.36e-14 | -6.05e-01 | 0.1278 |
3174 | HNF4G | A015-C-203 | Human | Colorectum | FAP | 3.82e-45 | -9.18e-01 | -0.1294 |
3174 | HNF4G | A015-C-204 | Human | Colorectum | FAP | 1.24e-20 | -7.38e-01 | -0.0228 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:00305221 | Colorectum | SER | intracellular receptor signaling pathway | 63/2897 | 265/18723 | 2.47e-04 | 4.20e-03 | 63 |
GO:00305222 | Colorectum | MSS | intracellular receptor signaling pathway | 84/3467 | 265/18723 | 1.47e-07 | 6.79e-06 | 84 |
GO:00305223 | Colorectum | FAP | intracellular receptor signaling pathway | 67/2622 | 265/18723 | 6.84e-07 | 3.28e-05 | 67 |
GO:00305224 | Colorectum | CRC | intracellular receptor signaling pathway | 61/2078 | 265/18723 | 2.00e-08 | 3.23e-06 | 61 |
GO:00305226 | Liver | NAFLD | intracellular receptor signaling pathway | 55/1882 | 265/18723 | 1.39e-07 | 1.03e-05 | 55 |
GO:003052212 | Liver | Cirrhotic | intracellular receptor signaling pathway | 105/4634 | 265/18723 | 5.44e-08 | 1.69e-06 | 105 |
GO:003052222 | Liver | HCC | intracellular receptor signaling pathway | 171/7958 | 265/18723 | 3.00e-13 | 1.61e-11 | 171 |
GO:00305225 | Stomach | GC | intracellular receptor signaling pathway | 28/1159 | 265/18723 | 4.04e-03 | 3.39e-02 | 28 |
GO:003052211 | Stomach | CAG with IM | intracellular receptor signaling pathway | 28/1050 | 265/18723 | 9.76e-04 | 1.26e-02 | 28 |
GO:003052221 | Stomach | CSG | intracellular receptor signaling pathway | 28/1034 | 265/18723 | 7.73e-04 | 1.06e-02 | 28 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNF4G | SNV | Missense_Mutation | novel | c.106A>G | p.Thr36Ala | p.T36A | Q14541 | protein_coding | tolerated(0.9) | benign(0) | TCGA-D7-6822-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HNF4G | SNV | Missense_Mutation | novel | c.199N>A | p.Asp67Asn | p.D67N | Q14541 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-R5-A7ZE-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
HNF4G | SNV | Missense_Mutation | novel | c.24A>C | p.Glu8Asp | p.E8D | Q14541 | protein_coding | tolerated(0.46) | benign(0.007) | TCGA-R5-A805-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HNF4G | insertion | In_Frame_Ins | novel | c.1310_1311insATACACATTAGC | p.Gln437_His438insTyrThrLeuAla | p.Q437_H438insYTLA | Q14541 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |