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Gene: HELLS |
Gene summary for HELLS |
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Gene information | Species | Human | Gene symbol | HELLS | Gene ID | 3070 |
Gene name | helicase, lymphoid specific | |
Gene Alias | ICF4 | |
Cytomap | 10q23.33 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | A0A0B4J1V9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3070 | HELLS | LZE7T | Human | Esophagus | ESCC | 6.76e-10 | 4.57e-01 | 0.0667 |
3070 | HELLS | LZE22T | Human | Esophagus | ESCC | 9.88e-05 | 3.81e-01 | 0.068 |
3070 | HELLS | LZE24T | Human | Esophagus | ESCC | 9.14e-04 | 1.64e-01 | 0.0596 |
3070 | HELLS | P1T-E | Human | Esophagus | ESCC | 1.91e-06 | 5.51e-01 | 0.0875 |
3070 | HELLS | P2T-E | Human | Esophagus | ESCC | 1.76e-44 | 1.05e+00 | 0.1177 |
3070 | HELLS | P4T-E | Human | Esophagus | ESCC | 1.31e-20 | 6.29e-01 | 0.1323 |
3070 | HELLS | P5T-E | Human | Esophagus | ESCC | 2.16e-17 | 4.43e-01 | 0.1327 |
3070 | HELLS | P8T-E | Human | Esophagus | ESCC | 3.93e-12 | 4.74e-01 | 0.0889 |
3070 | HELLS | P9T-E | Human | Esophagus | ESCC | 7.07e-06 | 1.35e-01 | 0.1131 |
3070 | HELLS | P10T-E | Human | Esophagus | ESCC | 1.01e-09 | 2.65e-01 | 0.116 |
3070 | HELLS | P11T-E | Human | Esophagus | ESCC | 1.53e-02 | 2.74e-01 | 0.1426 |
3070 | HELLS | P12T-E | Human | Esophagus | ESCC | 3.71e-12 | 3.85e-01 | 0.1122 |
3070 | HELLS | P15T-E | Human | Esophagus | ESCC | 1.21e-08 | 2.45e-01 | 0.1149 |
3070 | HELLS | P16T-E | Human | Esophagus | ESCC | 3.93e-17 | 4.10e-01 | 0.1153 |
3070 | HELLS | P17T-E | Human | Esophagus | ESCC | 3.62e-08 | 3.81e-01 | 0.1278 |
3070 | HELLS | P19T-E | Human | Esophagus | ESCC | 9.54e-03 | 2.16e-01 | 0.1662 |
3070 | HELLS | P20T-E | Human | Esophagus | ESCC | 7.16e-03 | 1.62e-01 | 0.1124 |
3070 | HELLS | P21T-E | Human | Esophagus | ESCC | 1.31e-04 | 1.96e-01 | 0.1617 |
3070 | HELLS | P22T-E | Human | Esophagus | ESCC | 1.54e-07 | 2.19e-01 | 0.1236 |
3070 | HELLS | P23T-E | Human | Esophagus | ESCC | 1.44e-06 | 3.09e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00400295 | Esophagus | ESCC | regulation of gene expression, epigenetic | 74/8552 | 105/18723 | 2.24e-07 | 3.42e-06 | 74 |
GO:00345081 | Esophagus | ESCC | centromere complex assembly | 25/8552 | 30/18723 | 2.45e-05 | 2.09e-04 | 25 |
GO:199082316 | Esophagus | ESCC | response to leukemia inhibitory factor | 60/8552 | 95/18723 | 4.41e-04 | 2.48e-03 | 60 |
GO:199083015 | Esophagus | ESCC | cellular response to leukemia inhibitory factor | 59/8552 | 94/18723 | 6.19e-04 | 3.32e-03 | 59 |
GO:00708281 | Esophagus | ESCC | heterochromatin organization | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:0031055 | Esophagus | ESCC | chromatin remodeling at centromere | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:0045814 | Esophagus | ESCC | negative regulation of gene expression, epigenetic | 32/8552 | 50/18723 | 6.90e-03 | 2.52e-02 | 32 |
GO:00016559 | Esophagus | ESCC | urogenital system development | 177/8552 | 338/18723 | 7.51e-03 | 2.69e-02 | 177 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
GO:009719322 | Liver | HCC | intrinsic apoptotic signaling pathway | 184/7958 | 288/18723 | 1.50e-13 | 8.32e-12 | 184 |
GO:200123412 | Liver | HCC | negative regulation of apoptotic signaling pathway | 145/7958 | 224/18723 | 1.33e-11 | 5.36e-10 | 145 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HELLS | SNV | Missense_Mutation | novel | c.808G>T | p.Val270Leu | p.V270L | protein_coding | deleterious(0.02) | possibly_damaging(0.835) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HELLS | SNV | Missense_Mutation | c.1840N>T | p.Arg614Cys | p.R614C | protein_coding | deleterious(0) | benign(0.178) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | ||
HELLS | insertion | Frame_Shift_Ins | novel | c.292_293insA | p.Leu100IlefsTer11 | p.L100Ifs*11 | protein_coding | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |||
HELLS | deletion | Frame_Shift_Del | rs775038246 | c.461delA | p.Asn154IlefsTer29 | p.N154Ifs*29 | protein_coding | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |||
HELLS | deletion | Frame_Shift_Del | rs775038246 | c.454delN | p.Asn154IlefsTer29 | p.N154Ifs*29 | protein_coding | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
HELLS | SNV | Missense_Mutation | c.611N>G | p.Lys204Arg | p.K204R | protein_coding | tolerated(0.17) | possibly_damaging(0.652) | TCGA-44-6774-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | alimta | SD | ||
HELLS | SNV | Missense_Mutation | novel | c.80C>G | p.Thr27Ser | p.T27S | protein_coding | tolerated(0.1) | probably_damaging(0.995) | TCGA-55-8614-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HELLS | SNV | Missense_Mutation | novel | c.1651N>G | p.Thr551Ala | p.T551A | protein_coding | tolerated(0.25) | benign(0.167) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
HELLS | SNV | Missense_Mutation | novel | c.655A>T | p.Thr219Ser | p.T219S | protein_coding | tolerated(0.07) | possibly_damaging(0.722) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HELLS | SNV | Missense_Mutation | novel | c.2069N>T | p.Arg690Met | p.R690M | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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