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Gene: GSG2 |
Gene summary for GSG2 |
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Gene information | Species | Human | Gene symbol | GSG2 | Gene ID | 83903 |
Gene name | histone H3 associated protein kinase | |
Gene Alias | GSG2 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0PJ70 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83903 | GSG2 | HCC2 | Human | Liver | HCC | 3.10e-11 | 5.90e-01 | 0.5341 |
83903 | GSG2 | HCC5 | Human | Liver | HCC | 1.23e-09 | 5.99e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSG2 | SNV | Missense_Mutation | c.1402N>G | p.Ser468Gly | p.S468G | Q8TF76 | protein_coding | tolerated(0.19) | benign(0) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GSG2 | SNV | Missense_Mutation | c.410C>T | p.Pro137Leu | p.P137L | Q8TF76 | protein_coding | deleterious_low_confidence(0.04) | benign(0.003) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
GSG2 | deletion | Frame_Shift_Del | c.1776delN | p.Phe594LeufsTer19 | p.F594Lfs*19 | Q8TF76 | protein_coding | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
GSG2 | insertion | Frame_Shift_Ins | novel | c.1782dupT | p.Lys595Ter | p.K595* | Q8TF76 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
GSG2 | deletion | Frame_Shift_Del | c.1987delN | p.Lys664AsnfsTer20 | p.K664Nfs*20 | Q8TF76 | protein_coding | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
GSG2 | insertion | Frame_Shift_Ins | novel | c.2202_2203insA | p.Glu735ArgfsTer6 | p.E735Rfs*6 | Q8TF76 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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