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Gene: GPATCH2 |
Gene summary for GPATCH2 |
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Gene information | Species | Human | Gene symbol | GPATCH2 | Gene ID | 55105 |
Gene name | G-patch domain containing 2 | |
Gene Alias | CT110 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NW75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55105 | GPATCH2 | CCI_1 | Human | Cervix | CC | 1.77e-04 | 7.31e-01 | 0.528 |
55105 | GPATCH2 | CCI_2 | Human | Cervix | CC | 6.18e-05 | 6.87e-01 | 0.5249 |
55105 | GPATCH2 | CCI_3 | Human | Cervix | CC | 4.94e-10 | 9.19e-01 | 0.516 |
55105 | GPATCH2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.03e-10 | -5.15e-01 | 0.0155 |
55105 | GPATCH2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.27e-03 | -4.67e-01 | -0.1207 |
55105 | GPATCH2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.09e-09 | -5.15e-01 | 0.096 |
55105 | GPATCH2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.52e-05 | -3.80e-01 | 0.0674 |
55105 | GPATCH2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.89e-09 | -3.23e-01 | 0.294 |
55105 | GPATCH2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.56e-11 | -4.67e-01 | 0.3005 |
55105 | GPATCH2 | A001-C-207 | Human | Colorectum | FAP | 1.16e-02 | -3.24e-01 | 0.1278 |
55105 | GPATCH2 | A015-C-203 | Human | Colorectum | FAP | 2.41e-21 | -3.04e-01 | -0.1294 |
55105 | GPATCH2 | A015-C-204 | Human | Colorectum | FAP | 3.89e-03 | -1.30e-01 | -0.0228 |
55105 | GPATCH2 | A014-C-040 | Human | Colorectum | FAP | 1.13e-02 | -3.93e-01 | -0.1184 |
55105 | GPATCH2 | A002-C-201 | Human | Colorectum | FAP | 4.60e-06 | -2.08e-01 | 0.0324 |
55105 | GPATCH2 | A002-C-203 | Human | Colorectum | FAP | 4.13e-03 | -1.67e-01 | 0.2786 |
55105 | GPATCH2 | A001-C-119 | Human | Colorectum | FAP | 3.94e-04 | -3.65e-01 | -0.1557 |
55105 | GPATCH2 | A001-C-108 | Human | Colorectum | FAP | 1.12e-10 | -1.71e-01 | -0.0272 |
55105 | GPATCH2 | A002-C-205 | Human | Colorectum | FAP | 1.03e-16 | -2.73e-01 | -0.1236 |
55105 | GPATCH2 | A015-C-005 | Human | Colorectum | FAP | 4.08e-02 | -1.71e-01 | -0.0336 |
55105 | GPATCH2 | A015-C-006 | Human | Colorectum | FAP | 2.44e-08 | -2.32e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPATCH2 | SNV | Missense_Mutation | novel | c.343N>G | p.Ser115Gly | p.S115G | Q9NW75 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-90-7766-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GPATCH2 | SNV | Missense_Mutation | novel | c.928N>T | p.Pro310Ser | p.P310S | Q9NW75 | protein_coding | tolerated(0.89) | benign(0) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GPATCH2 | SNV | Missense_Mutation | novel | c.200A>C | p.Lys67Thr | p.K67T | Q9NW75 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-98-A53A-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GPATCH2 | SNV | Missense_Mutation | novel | c.1367G>T | p.Gly456Val | p.G456V | Q9NW75 | protein_coding | deleterious(0.01) | benign(0.204) | TCGA-NC-A5HQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
GPATCH2 | deletion | Frame_Shift_Del | novel | c.336delA | p.Asp113IlefsTer10 | p.D113Ifs*10 | Q9NW75 | protein_coding | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
GPATCH2 | SNV | Missense_Mutation | novel | c.1220N>A | p.Arg407Lys | p.R407K | Q9NW75 | protein_coding | tolerated(0.3) | benign(0.388) | TCGA-BB-4225-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unspecific | SD | |
GPATCH2 | SNV | Missense_Mutation | novel | c.1460N>T | p.Gly487Val | p.G487V | Q9NW75 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GPATCH2 | SNV | Missense_Mutation | novel | c.1031G>T | p.Arg344Ile | p.R344I | Q9NW75 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GPATCH2 | SNV | Missense_Mutation | c.218N>A | p.Arg73Gln | p.R73Q | Q9NW75 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPATCH2 | SNV | Missense_Mutation | rs150988724 | c.476N>A | p.Arg159His | p.R159H | Q9NW75 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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