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Gene: GON4L |
Gene summary for GON4L |
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Gene information | Species | Human | Gene symbol | GON4L | Gene ID | 54856 |
Gene name | gon-4 like | |
Gene Alias | GON-4 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q3T8J9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54856 | GON4L | CA_HPV_1 | Human | Cervix | CC | 1.09e-02 | 1.13e-02 | 0.0264 |
54856 | GON4L | CCI_1 | Human | Cervix | CC | 1.41e-08 | 7.93e-01 | 0.528 |
54856 | GON4L | CCI_2 | Human | Cervix | CC | 2.04e-02 | 4.15e-01 | 0.5249 |
54856 | GON4L | CCI_3 | Human | Cervix | CC | 1.41e-10 | 7.04e-01 | 0.516 |
54856 | GON4L | AEH-subject2 | Human | Endometrium | AEH | 1.35e-08 | 1.07e-01 | -0.2525 |
54856 | GON4L | AEH-subject3 | Human | Endometrium | AEH | 4.95e-05 | 2.08e-01 | -0.2576 |
54856 | GON4L | EEC-subject2 | Human | Endometrium | EEC | 1.28e-04 | 2.43e-01 | -0.2607 |
54856 | GON4L | EEC-subject3 | Human | Endometrium | EEC | 2.63e-07 | 4.05e-02 | -0.2525 |
54856 | GON4L | GSM5276935 | Human | Endometrium | EEC | 1.17e-03 | 3.00e-01 | -0.123 |
54856 | GON4L | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.71e-21 | -1.54e-01 | -0.1869 |
54856 | GON4L | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 6.39e-17 | -2.12e-01 | -0.1875 |
54856 | GON4L | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.29e-19 | -2.19e-01 | -0.1883 |
54856 | GON4L | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 9.33e-16 | 2.88e-02 | -0.1934 |
54856 | GON4L | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.44e-27 | -1.33e-01 | -0.1917 |
54856 | GON4L | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.96e-25 | -1.37e-01 | -0.1916 |
54856 | GON4L | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.04e-02 | -8.27e-02 | -0.1269 |
54856 | GON4L | LZE2D | Human | Esophagus | HGIN | 1.80e-02 | 5.79e-01 | 0.0642 |
54856 | GON4L | LZE2T | Human | Esophagus | ESCC | 4.44e-04 | 6.84e-01 | 0.082 |
54856 | GON4L | LZE3D | Human | Esophagus | HGIN | 1.45e-02 | 4.32e-01 | 0.0668 |
54856 | GON4L | LZE4T | Human | Esophagus | ESCC | 2.53e-20 | 5.24e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19031314 | Cervix | CC | mononuclear cell differentiation | 76/2311 | 426/18723 | 5.66e-04 | 5.42e-03 | 76 |
GO:00300981 | Cervix | CC | lymphocyte differentiation | 63/2311 | 374/18723 | 6.21e-03 | 3.52e-02 | 63 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
GO:19031311 | Lung | IAC | mononuclear cell differentiation | 66/2061 | 426/18723 | 2.63e-03 | 2.44e-02 | 66 |
GO:19031316 | Oral cavity | OSCC | mononuclear cell differentiation | 210/7305 | 426/18723 | 8.44e-06 | 9.02e-05 | 210 |
GO:00300983 | Oral cavity | OSCC | lymphocyte differentiation | 179/7305 | 374/18723 | 2.74e-04 | 1.74e-03 | 179 |
GO:190313114 | Oral cavity | EOLP | mononuclear cell differentiation | 88/2218 | 426/18723 | 1.07e-07 | 3.61e-06 | 88 |
GO:003009812 | Oral cavity | EOLP | lymphocyte differentiation | 76/2218 | 374/18723 | 1.50e-06 | 3.55e-05 | 76 |
GO:00421132 | Oral cavity | EOLP | B cell activation | 61/2218 | 334/18723 | 3.68e-04 | 3.35e-03 | 61 |
GO:190313122 | Oral cavity | NEOLP | mononuclear cell differentiation | 77/2005 | 426/18723 | 2.80e-06 | 6.41e-05 | 77 |
GO:003009821 | Oral cavity | NEOLP | lymphocyte differentiation | 66/2005 | 374/18723 | 3.08e-05 | 4.67e-04 | 66 |
GO:0030183 | Oral cavity | NEOLP | B cell differentiation | 25/2005 | 141/18723 | 7.85e-03 | 3.90e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GON4L | SNV | Missense_Mutation | novel | c.4922C>T | p.Ala1641Val | p.A1641V | Q3T8J9 | protein_coding | tolerated(0.07) | benign(0.341) | TCGA-AG-A01J-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GON4L | SNV | Missense_Mutation | c.3386C>A | p.Pro1129His | p.P1129H | Q3T8J9 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.695) | TCGA-AG-A01J-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GON4L | SNV | Missense_Mutation | c.5632N>T | p.Val1878Phe | p.V1878F | Q3T8J9 | protein_coding | tolerated(0.1) | probably_damaging(0.996) | TCGA-DC-6154-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
GON4L | SNV | Missense_Mutation | c.5326C>A | p.His1776Asn | p.H1776N | Q3T8J9 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GON4L | SNV | Missense_Mutation | c.2788N>A | p.Glu930Lys | p.E930K | Q3T8J9 | protein_coding | deleterious(0.04) | probably_damaging(0.993) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD | |
GON4L | SNV | Missense_Mutation | rs747050459 | c.875G>A | p.Arg292Gln | p.R292Q | Q3T8J9 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GON4L | deletion | Frame_Shift_Del | c.400delN | p.Met134Ter | p.M134* | Q3T8J9 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
GON4L | deletion | Frame_Shift_Del | c.400delN | p.Met134Ter | p.M134* | Q3T8J9 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
GON4L | insertion | Frame_Shift_Ins | novel | c.5490_5491insA | p.Glu1831ArgfsTer8 | p.E1831Rfs*8 | Q3T8J9 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
GON4L | SNV | Missense_Mutation | novel | c.4862N>A | p.Pro1621Gln | p.P1621Q | Q3T8J9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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