![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GFM1 |
Gene summary for GFM1 |
![]() |
Gene information | Species | Human | Gene symbol | GFM1 | Gene ID | 85476 |
Gene name | G elongation factor mitochondrial 1 | |
Gene Alias | COXPD1 | |
Cytomap | 3q25.32 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q96RP9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85476 | GFM1 | LZE2T | Human | Esophagus | ESCC | 2.14e-03 | 5.50e-01 | 0.082 |
85476 | GFM1 | LZE4T | Human | Esophagus | ESCC | 1.17e-14 | 3.80e-01 | 0.0811 |
85476 | GFM1 | LZE7T | Human | Esophagus | ESCC | 1.67e-07 | 3.60e-01 | 0.0667 |
85476 | GFM1 | LZE8T | Human | Esophagus | ESCC | 2.78e-06 | 2.94e-01 | 0.067 |
85476 | GFM1 | LZE20T | Human | Esophagus | ESCC | 1.16e-03 | 7.36e-02 | 0.0662 |
85476 | GFM1 | LZE22T | Human | Esophagus | ESCC | 1.26e-06 | 2.61e-01 | 0.068 |
85476 | GFM1 | LZE24D1 | Human | Esophagus | HGIN | 2.78e-02 | 3.84e-01 | 0.054 |
85476 | GFM1 | LZE24T | Human | Esophagus | ESCC | 1.59e-17 | 4.65e-01 | 0.0596 |
85476 | GFM1 | LZE21T | Human | Esophagus | ESCC | 6.03e-06 | 3.68e-01 | 0.0655 |
85476 | GFM1 | LZE6T | Human | Esophagus | ESCC | 1.51e-03 | 1.64e-01 | 0.0845 |
85476 | GFM1 | P1T-E | Human | Esophagus | ESCC | 2.04e-05 | 2.80e-01 | 0.0875 |
85476 | GFM1 | P2T-E | Human | Esophagus | ESCC | 1.03e-34 | 6.97e-01 | 0.1177 |
85476 | GFM1 | P4T-E | Human | Esophagus | ESCC | 6.12e-19 | 5.32e-01 | 0.1323 |
85476 | GFM1 | P5T-E | Human | Esophagus | ESCC | 2.09e-22 | 5.17e-01 | 0.1327 |
85476 | GFM1 | P8T-E | Human | Esophagus | ESCC | 6.25e-28 | 5.52e-01 | 0.0889 |
85476 | GFM1 | P9T-E | Human | Esophagus | ESCC | 8.40e-22 | 3.56e-01 | 0.1131 |
85476 | GFM1 | P10T-E | Human | Esophagus | ESCC | 5.28e-36 | 5.35e-01 | 0.116 |
85476 | GFM1 | P11T-E | Human | Esophagus | ESCC | 4.58e-18 | 4.37e-01 | 0.1426 |
85476 | GFM1 | P12T-E | Human | Esophagus | ESCC | 9.18e-27 | 3.86e-01 | 0.1122 |
85476 | GFM1 | P15T-E | Human | Esophagus | ESCC | 4.94e-32 | 7.06e-01 | 0.1149 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
GO:003254313 | Oral cavity | LP | mitochondrial translation | 43/4623 | 76/18723 | 2.85e-09 | 1.26e-07 | 43 |
GO:014005312 | Oral cavity | LP | mitochondrial gene expression | 53/4623 | 108/18723 | 3.54e-08 | 1.27e-06 | 53 |
GO:000641417 | Oral cavity | LP | translational elongation | 25/4623 | 55/18723 | 6.27e-04 | 5.71e-03 | 25 |
GO:00325436 | Skin | cSCC | mitochondrial translation | 47/4864 | 76/18723 | 4.70e-11 | 2.22e-09 | 47 |
GO:01400535 | Skin | cSCC | mitochondrial gene expression | 56/4864 | 108/18723 | 8.06e-09 | 2.56e-07 | 56 |
GO:000641423 | Skin | cSCC | translational elongation | 30/4864 | 55/18723 | 6.13e-06 | 8.70e-05 | 30 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GFM1 | SNV | Missense_Mutation | novel | c.1963N>A | p.Gln655Lys | p.Q655K | Q96RP9 | protein_coding | tolerated(0.33) | benign(0.09) | TCGA-77-A5G6-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
GFM1 | SNV | Missense_Mutation | c.1255C>A | p.Arg419Ser | p.R419S | Q96RP9 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
GFM1 | SNV | Missense_Mutation | novel | c.118N>A | p.Val40Met | p.V40M | Q96RP9 | protein_coding | tolerated(0.11) | benign(0.272) | TCGA-CV-7102-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GFM1 | SNV | Missense_Mutation | novel | c.1859G>C | p.Gly620Ala | p.G620A | Q96RP9 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-CV-7238-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GFM1 | SNV | Missense_Mutation | rs780073215 | c.2069N>A | p.Arg690His | p.R690H | Q96RP9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
GFM1 | SNV | Missense_Mutation | c.266N>C | p.Met89Thr | p.M89T | Q96RP9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GFM1 | SNV | Missense_Mutation | novel | c.893T>C | p.Leu298Ser | p.L298S | Q96RP9 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GFM1 | SNV | Missense_Mutation | rs780073215 | c.2069N>A | p.Arg690His | p.R690H | Q96RP9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GFM1 | insertion | Frame_Shift_Ins | novel | c.130_131insA | p.Ile46AsnfsTer11 | p.I46Nfs*11 | Q96RP9 | protein_coding | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | ||
GFM1 | insertion | Frame_Shift_Ins | novel | c.676_677insAAATGACAAA | p.Asp226GlufsTer34 | p.D226Efs*34 | Q96RP9 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |