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Gene: GAB2 |
Gene summary for GAB2 |
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Gene information | Species | Human | Gene symbol | GAB2 | Gene ID | 9846 |
Gene name | GRB2 associated binding protein 2 | |
Gene Alias | GAB2 | |
Cytomap | 11q14.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9UQC2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9846 | GAB2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.24e-10 | -4.90e-01 | 0.0155 |
9846 | GAB2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.06e-03 | -4.11e-01 | -0.1808 |
9846 | GAB2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.34e-03 | -3.79e-01 | -0.0811 |
9846 | GAB2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.13e-06 | -4.32e-01 | -0.1088 |
9846 | GAB2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.07e-04 | -5.05e-01 | -0.1207 |
9846 | GAB2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.66e-08 | -4.07e-01 | -0.1464 |
9846 | GAB2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.91e-04 | -4.09e-01 | -0.1001 |
9846 | GAB2 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.03e-08 | -4.36e-01 | 0.096 |
9846 | GAB2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.00e-06 | -5.20e-01 | 0.0338 |
9846 | GAB2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.14e-14 | -5.16e-01 | 0.0674 |
9846 | GAB2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.27e-04 | -3.74e-01 | 0.0588 |
9846 | GAB2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.53e-12 | -4.65e-01 | 0.294 |
9846 | GAB2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.60e-02 | -4.11e-01 | 0.281 |
9846 | GAB2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.18e-07 | -3.77e-01 | 0.3859 |
9846 | GAB2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.11e-03 | -4.96e-01 | 0.2585 |
9846 | GAB2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.08e-22 | -6.29e-01 | 0.3005 |
9846 | GAB2 | F007 | Human | Colorectum | FAP | 2.10e-03 | -3.15e-01 | 0.1176 |
9846 | GAB2 | A001-C-207 | Human | Colorectum | FAP | 4.28e-03 | -1.58e-01 | 0.1278 |
9846 | GAB2 | A015-C-203 | Human | Colorectum | FAP | 1.65e-28 | -5.04e-01 | -0.1294 |
9846 | GAB2 | A015-C-204 | Human | Colorectum | FAP | 1.83e-06 | -3.35e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0002573 | Colorectum | AD | myeloid leukocyte differentiation | 60/3918 | 208/18723 | 4.03e-03 | 2.81e-02 | 60 |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00459211 | Colorectum | SER | positive regulation of exocytosis | 25/2897 | 86/18723 | 9.88e-04 | 1.17e-02 | 25 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:00300991 | Colorectum | SER | myeloid cell differentiation | 80/2897 | 381/18723 | 2.28e-03 | 2.18e-02 | 80 |
GO:00480171 | Colorectum | SER | inositol lipid-mediated signaling | 42/2897 | 182/18723 | 4.36e-03 | 3.49e-02 | 42 |
GO:00480151 | Colorectum | SER | phosphatidylinositol-mediated signaling | 41/2897 | 178/18723 | 4.97e-03 | 3.86e-02 | 41 |
GO:00510471 | Colorectum | SER | positive regulation of secretion | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
GO:00171571 | Colorectum | SER | regulation of exocytosis | 45/2897 | 202/18723 | 6.46e-03 | 4.63e-02 | 45 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa05220 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
hsa04071 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa052201 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
hsa040711 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa046662 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa046663 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa046664 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa052202 | Colorectum | MSS | Chronic myeloid leukemia | 29/1875 | 76/8465 | 1.10e-03 | 6.27e-03 | 3.84e-03 | 29 |
hsa040712 | Colorectum | MSS | Sphingolipid signaling pathway | 40/1875 | 121/8465 | 3.56e-03 | 1.64e-02 | 1.01e-02 | 40 |
hsa046665 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa052203 | Colorectum | MSS | Chronic myeloid leukemia | 29/1875 | 76/8465 | 1.10e-03 | 6.27e-03 | 3.84e-03 | 29 |
hsa040713 | Colorectum | MSS | Sphingolipid signaling pathway | 40/1875 | 121/8465 | 3.56e-03 | 1.64e-02 | 1.01e-02 | 40 |
hsa046666 | Colorectum | FAP | Fc gamma R-mediated phagocytosis | 35/1404 | 97/8465 | 2.46e-06 | 4.28e-05 | 2.60e-05 | 35 |
hsa040714 | Colorectum | FAP | Sphingolipid signaling pathway | 34/1404 | 121/8465 | 9.53e-04 | 5.22e-03 | 3.17e-03 | 34 |
hsa052204 | Colorectum | FAP | Chronic myeloid leukemia | 23/1404 | 76/8465 | 2.14e-03 | 1.05e-02 | 6.39e-03 | 23 |
hsa046667 | Colorectum | FAP | Fc gamma R-mediated phagocytosis | 35/1404 | 97/8465 | 2.46e-06 | 4.28e-05 | 2.60e-05 | 35 |
hsa040715 | Colorectum | FAP | Sphingolipid signaling pathway | 34/1404 | 121/8465 | 9.53e-04 | 5.22e-03 | 3.17e-03 | 34 |
hsa052205 | Colorectum | FAP | Chronic myeloid leukemia | 23/1404 | 76/8465 | 2.14e-03 | 1.05e-02 | 6.39e-03 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAB2 | SNV | Missense_Mutation | novel | c.571G>A | p.Glu191Lys | p.E191K | Q9UQC2 | protein_coding | deleterious(0.01) | benign(0.073) | TCGA-CV-A6JM-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GAB2 | insertion | Nonsense_Mutation | novel | c.466_467insTTTAAAAAA | p.Arg156delinsLeuTerLysSer | p.R156delinsL*KS | Q9UQC2 | protein_coding | TCGA-CN-A497-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
GAB2 | deletion | Frame_Shift_Del | c.1535delN | p.Pro512LeufsTer19 | p.P512Lfs*19 | Q9UQC2 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
GAB2 | SNV | Missense_Mutation | rs781659629 | c.1990N>A | p.Val664Met | p.V664M | Q9UQC2 | protein_coding | tolerated(0.23) | probably_damaging(0.997) | TCGA-EJ-A46F-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | PD |
GAB2 | SNV | Missense_Mutation | c.1332C>G | p.Asp444Glu | p.D444E | Q9UQC2 | protein_coding | tolerated(0.3) | benign(0.037) | TCGA-EJ-A65J-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
GAB2 | SNV | Missense_Mutation | rs767427723 | c.419N>T | p.Ser140Phe | p.S140F | Q9UQC2 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-HC-7232-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
GAB2 | SNV | Missense_Mutation | rs762862308 | c.881C>A | p.Thr294Asn | p.T294N | Q9UQC2 | protein_coding | deleterious(0.04) | benign(0.261) | TCGA-HC-8264-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
GAB2 | SNV | Missense_Mutation | c.2016G>T | p.Lys672Asn | p.K672N | Q9UQC2 | protein_coding | deleterious(0.02) | probably_damaging(0.97) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GAB2 | SNV | Missense_Mutation | rs750289098 | c.1169A>G | p.Asn390Ser | p.N390S | Q9UQC2 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GAB2 | SNV | Missense_Mutation | c.1562N>A | p.Arg521Gln | p.R521Q | Q9UQC2 | protein_coding | deleterious(0.04) | possibly_damaging(0.778) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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