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Gene: FUBP1 |
Gene summary for FUBP1 |
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Gene information | Species | Human | Gene symbol | FUBP1 | Gene ID | 8880 |
Gene name | far upstream element binding protein 1 | |
Gene Alias | FBP | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B4DT31 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8880 | FUBP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.02e-19 | -5.62e-01 | 0.0155 |
8880 | FUBP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.74e-04 | -4.07e-01 | -0.1808 |
8880 | FUBP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.59e-05 | -4.99e-01 | -0.1207 |
8880 | FUBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.45e-04 | -3.46e-01 | -0.1464 |
8880 | FUBP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.22e-07 | -4.08e-01 | -0.1001 |
8880 | FUBP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.14e-04 | -6.15e-01 | -0.2061 |
8880 | FUBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.79e-05 | -3.35e-01 | 0.096 |
8880 | FUBP1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.19e-05 | -4.69e-01 | 0.0338 |
8880 | FUBP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.16e-06 | -4.05e-01 | 0.0674 |
8880 | FUBP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.89e-13 | -4.69e-01 | 0.3005 |
8880 | FUBP1 | F007 | Human | Colorectum | FAP | 5.48e-04 | -2.72e-01 | 0.1176 |
8880 | FUBP1 | A001-C-207 | Human | Colorectum | FAP | 9.12e-06 | -2.65e-01 | 0.1278 |
8880 | FUBP1 | A015-C-203 | Human | Colorectum | FAP | 9.95e-26 | -3.95e-01 | -0.1294 |
8880 | FUBP1 | A015-C-204 | Human | Colorectum | FAP | 4.72e-14 | -4.23e-01 | -0.0228 |
8880 | FUBP1 | A014-C-040 | Human | Colorectum | FAP | 1.08e-05 | -3.23e-01 | -0.1184 |
8880 | FUBP1 | A002-C-201 | Human | Colorectum | FAP | 3.44e-21 | -3.79e-01 | 0.0324 |
8880 | FUBP1 | A002-C-203 | Human | Colorectum | FAP | 4.00e-04 | -1.82e-01 | 0.2786 |
8880 | FUBP1 | A001-C-119 | Human | Colorectum | FAP | 1.77e-10 | -3.65e-01 | -0.1557 |
8880 | FUBP1 | A001-C-108 | Human | Colorectum | FAP | 2.95e-16 | -2.01e-01 | -0.0272 |
8880 | FUBP1 | A002-C-205 | Human | Colorectum | FAP | 4.09e-26 | -3.28e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FUBP1 | SNV | Missense_Mutation | novel | c.5C>T | p.Ala2Val | p.A2V | Q96AE4 | protein_coding | deleterious(0.02) | possibly_damaging(0.584) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FUBP1 | deletion | Frame_Shift_Del | novel | c.1638_1654delNNNNNNNNNNNNNNNNN | p.Gln546HisfsTer15 | p.Q546Hfs*15 | Q96AE4 | protein_coding | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
FUBP1 | deletion | Frame_Shift_Del | novel | c.79_82delNNNN | p.Val27ThrfsTer26 | p.V27Tfs*26 | Q96AE4 | protein_coding | TCGA-39-5039-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
FUBP1 | SNV | Missense_Mutation | novel | c.794G>A | p.Arg265Gln | p.R265Q | Q96AE4 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BA-7269-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
FUBP1 | SNV | Missense_Mutation | novel | c.1832A>G | p.Tyr611Cys | p.Y611C | Q96AE4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FUBP1 | SNV | Missense_Mutation | novel | c.1239N>C | p.Gln413His | p.Q413H | Q96AE4 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-CN-5374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
FUBP1 | SNV | Missense_Mutation | novel | c.1486C>T | p.Pro496Ser | p.P496S | Q96AE4 | protein_coding | tolerated(0.22) | benign(0.269) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
FUBP1 | SNV | Missense_Mutation | c.1609N>C | p.Trp537Arg | p.W537R | Q96AE4 | protein_coding | deleterious(0.03) | probably_damaging(0.969) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FUBP1 | SNV | Missense_Mutation | rs556028059 | c.548C>T | p.Pro183Leu | p.P183L | Q96AE4 | protein_coding | tolerated(0.29) | benign(0.031) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FUBP1 | SNV | Missense_Mutation | c.1270N>G | p.Met424Val | p.M424V | Q96AE4 | protein_coding | tolerated(1) | benign(0) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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