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Gene: FSIP2 |
Gene summary for FSIP2 |
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Gene information | Species | Human | Gene symbol | FSIP2 | Gene ID | 401024 |
Gene name | fibrous sheath interacting protein 2 | |
Gene Alias | SPGF34 | |
Cytomap | 2q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q5CZC0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401024 | FSIP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.93e-02 | 7.74e-02 | 0.0155 |
401024 | FSIP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.63e-05 | 5.39e-01 | -0.1088 |
401024 | FSIP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.40e-09 | 4.97e-01 | 0.0674 |
401024 | FSIP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.98e-04 | 3.12e-01 | 0.294 |
401024 | FSIP2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.67e-05 | 6.67e-01 | 0.281 |
401024 | FSIP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.76e-02 | 3.74e-01 | 0.3859 |
401024 | FSIP2 | CRC-3-11773 | Human | Colorectum | CRC | 9.36e-06 | -2.06e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FSIP2 | SNV | Missense_Mutation | c.18862T>G | p.Leu6288Val | p.L6288V | Q5CZC0 | protein_coding | probably_damaging(0.99) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
FSIP2 | SNV | Missense_Mutation | c.18013N>G | p.Thr6005Ala | p.T6005A | Q5CZC0 | protein_coding | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | ||
FSIP2 | SNV | Missense_Mutation | c.18887N>T | p.Ser6296Phe | p.S6296F | Q5CZC0 | protein_coding | probably_damaging(0.995) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | ||
FSIP2 | SNV | Missense_Mutation | c.19171N>A | p.Ala6391Thr | p.A6391T | Q5CZC0 | protein_coding | benign(0.091) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | ||
FSIP2 | SNV | Missense_Mutation | c.19670A>G | p.Glu6557Gly | p.E6557G | Q5CZC0 | protein_coding | possibly_damaging(0.814) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FSIP2 | SNV | Missense_Mutation | c.20436A>C | p.Glu6812Asp | p.E6812D | Q5CZC0 | protein_coding | possibly_damaging(0.878) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FSIP2 | SNV | Missense_Mutation | novel | c.17947N>A | p.Val5983Ile | p.V5983I | Q5CZC0 | protein_coding | benign(0.237) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FSIP2 | SNV | Missense_Mutation | novel | c.19582N>C | p.Lys6528Gln | p.K6528Q | Q5CZC0 | protein_coding | benign(0.372) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FSIP2 | SNV | Missense_Mutation | c.16412N>T | p.Arg5471Ile | p.R5471I | Q5CZC0 | protein_coding | possibly_damaging(0.516) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | ||
FSIP2 | SNV | Missense_Mutation | novel | c.18974N>G | p.Ile6325Ser | p.I6325S | Q5CZC0 | protein_coding | probably_damaging(0.974) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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