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Gene: FOXK1 |
Gene summary for FOXK1 |
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Gene information | Species | Human | Gene symbol | FOXK1 | Gene ID | 221937 |
Gene name | forkhead box K1 | |
Gene Alias | FOXK1L | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P85037 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221937 | FOXK1 | CCI_1 | Human | Cervix | CC | 7.80e-15 | 9.32e-01 | 0.528 |
221937 | FOXK1 | CCI_2 | Human | Cervix | CC | 2.38e-14 | 1.21e+00 | 0.5249 |
221937 | FOXK1 | CCI_3 | Human | Cervix | CC | 4.97e-19 | 1.04e+00 | 0.516 |
221937 | FOXK1 | LZE7T | Human | Esophagus | ESCC | 8.27e-05 | 2.23e-01 | 0.0667 |
221937 | FOXK1 | LZE24T | Human | Esophagus | ESCC | 8.17e-04 | 4.31e-02 | 0.0596 |
221937 | FOXK1 | P1T-E | Human | Esophagus | ESCC | 6.56e-05 | 1.68e-01 | 0.0875 |
221937 | FOXK1 | P2T-E | Human | Esophagus | ESCC | 2.44e-15 | 3.86e-02 | 0.1177 |
221937 | FOXK1 | P4T-E | Human | Esophagus | ESCC | 4.51e-08 | 7.52e-02 | 0.1323 |
221937 | FOXK1 | P5T-E | Human | Esophagus | ESCC | 8.03e-12 | 4.74e-02 | 0.1327 |
221937 | FOXK1 | P8T-E | Human | Esophagus | ESCC | 1.31e-14 | 1.00e-01 | 0.0889 |
221937 | FOXK1 | P9T-E | Human | Esophagus | ESCC | 3.30e-11 | 1.87e-01 | 0.1131 |
221937 | FOXK1 | P10T-E | Human | Esophagus | ESCC | 2.31e-20 | 4.80e-01 | 0.116 |
221937 | FOXK1 | P11T-E | Human | Esophagus | ESCC | 4.26e-02 | 6.49e-02 | 0.1426 |
221937 | FOXK1 | P12T-E | Human | Esophagus | ESCC | 1.21e-13 | 1.54e-02 | 0.1122 |
221937 | FOXK1 | P15T-E | Human | Esophagus | ESCC | 2.94e-12 | 1.77e-01 | 0.1149 |
221937 | FOXK1 | P16T-E | Human | Esophagus | ESCC | 6.24e-12 | 4.94e-02 | 0.1153 |
221937 | FOXK1 | P17T-E | Human | Esophagus | ESCC | 5.05e-09 | 2.02e-01 | 0.1278 |
221937 | FOXK1 | P20T-E | Human | Esophagus | ESCC | 3.28e-02 | -3.29e-02 | 0.1124 |
221937 | FOXK1 | P21T-E | Human | Esophagus | ESCC | 7.19e-06 | 4.56e-02 | 0.1617 |
221937 | FOXK1 | P22T-E | Human | Esophagus | ESCC | 6.41e-06 | -1.26e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00425948 | Cervix | CC | response to starvation | 46/2311 | 197/18723 | 1.24e-05 | 2.59e-04 | 46 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:00196939 | Cervix | CC | ribose phosphate metabolic process | 72/2311 | 396/18723 | 4.49e-04 | 4.48e-03 | 72 |
GO:00092599 | Cervix | CC | ribonucleotide metabolic process | 70/2311 | 385/18723 | 5.35e-04 | 5.18e-03 | 70 |
GO:00425939 | Cervix | CC | glucose homeostasis | 50/2311 | 258/18723 | 7.57e-04 | 6.76e-03 | 50 |
GO:00335009 | Cervix | CC | carbohydrate homeostasis | 50/2311 | 259/18723 | 8.28e-04 | 7.22e-03 | 50 |
GO:00016788 | Cervix | CC | cellular glucose homeostasis | 36/2311 | 172/18723 | 9.65e-04 | 8.09e-03 | 36 |
GO:000915010 | Cervix | CC | purine ribonucleotide metabolic process | 66/2311 | 368/18723 | 1.09e-03 | 9.07e-03 | 66 |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:000616310 | Cervix | CC | purine nucleotide metabolic process | 67/2311 | 396/18723 | 4.41e-03 | 2.69e-02 | 67 |
GO:007252110 | Cervix | CC | purine-containing compound metabolic process | 69/2311 | 416/18723 | 6.27e-03 | 3.54e-02 | 69 |
GO:00067346 | Cervix | CC | NADH metabolic process | 9/2311 | 29/18723 | 6.49e-03 | 3.61e-02 | 9 |
GO:000913510 | Cervix | CC | purine nucleoside diphosphate metabolic process | 22/2311 | 103/18723 | 6.75e-03 | 3.71e-02 | 22 |
GO:000917910 | Cervix | CC | purine ribonucleoside diphosphate metabolic process | 22/2311 | 103/18723 | 6.75e-03 | 3.71e-02 | 22 |
GO:000911710 | Cervix | CC | nucleotide metabolic process | 79/2311 | 489/18723 | 7.16e-03 | 3.85e-02 | 79 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXK1 | SNV | Missense_Mutation | novel | c.1202N>C | p.Gly401Ala | p.G401A | P85037 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
FOXK1 | SNV | Missense_Mutation | c.1274G>T | p.Gly425Val | p.G425V | P85037 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
FOXK1 | SNV | Missense_Mutation | novel | c.778N>T | p.Gly260Cys | p.G260C | P85037 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
FOXK1 | SNV | Missense_Mutation | novel | c.1412N>C | p.Gly471Ala | p.G471A | P85037 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FOXK1 | SNV | Missense_Mutation | novel | c.841N>A | p.Glu281Lys | p.E281K | P85037 | protein_coding | tolerated(0.07) | probably_damaging(0.985) | TCGA-66-2768-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOXK1 | SNV | Missense_Mutation | c.1450N>G | p.Pro484Ala | p.P484A | P85037 | protein_coding | deleterious(0.02) | possibly_damaging(0.73) | TCGA-70-6723-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FOXK1 | SNV | Missense_Mutation | novel | c.697N>A | p.Asp233Asn | p.D233N | P85037 | protein_coding | tolerated(0.68) | benign(0.01) | TCGA-77-8009-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FOXK1 | SNV | Missense_Mutation | novel | c.1197N>C | p.Gln399His | p.Q399H | P85037 | protein_coding | deleterious(0.01) | possibly_damaging(0.867) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FOXK1 | SNV | Missense_Mutation | novel | c.1702N>C | p.Glu568Gln | p.E568Q | P85037 | protein_coding | tolerated(0.06) | possibly_damaging(0.863) | TCGA-CR-6484-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
FOXK1 | SNV | Missense_Mutation | novel | c.375N>G | p.Ile125Met | p.I125M | P85037 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-CR-7374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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