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Gene: FOXA2 |
Gene summary for FOXA2 |
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Gene information | Species | Human | Gene symbol | FOXA2 | Gene ID | 3170 |
Gene name | forkhead box A2 | |
Gene Alias | HNF-3-beta | |
Cytomap | 20p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000429 | UniProtAcc | B0ZTD4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3170 | FOXA2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.47e-03 | 1.03e-01 | 0.0155 |
3170 | FOXA2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.42e-05 | 1.98e-01 | -0.1808 |
3170 | FOXA2 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.21e-16 | 4.30e-01 | -0.1088 |
3170 | FOXA2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.95e-18 | 4.07e-01 | -0.1954 |
3170 | FOXA2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-11 | 8.79e-01 | -0.2602 |
3170 | FOXA2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.37e-01 | -0.2196 |
3170 | FOXA2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.57e-06 | 2.57e-01 | -0.1207 |
3170 | FOXA2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.63e-22 | 5.14e-01 | -0.1464 |
3170 | FOXA2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.28e-10 | 2.59e-01 | -0.1001 |
3170 | FOXA2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.63e-07 | 2.56e-01 | -0.059 |
3170 | FOXA2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 3.79e-01 | -0.1706 |
3170 | FOXA2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.03e-03 | 1.93e-01 | -0.2061 |
3170 | FOXA2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-06 | 2.90e-01 | -0.0842 |
3170 | FOXA2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.15e-10 | 3.55e-01 | -0.0179 |
3170 | FOXA2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.30e-20 | 4.39e-01 | 0.096 |
3170 | FOXA2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 4.41e-01 | 0.0446 |
3170 | FOXA2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.89e-10 | 4.21e-01 | 0.0528 |
3170 | FOXA2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.21e-02 | 2.06e-01 | 0.0171 |
3170 | FOXA2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.05e-06 | 1.84e-01 | 0.0674 |
3170 | FOXA2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.00e-08 | 4.88e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009743 | Colorectum | AD | response to carbohydrate | 86/3918 | 253/18723 | 8.43e-07 | 2.90e-05 | 86 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0034284 | Colorectum | AD | response to monosaccharide | 76/3918 | 225/18723 | 4.64e-06 | 1.23e-04 | 76 |
GO:0033500 | Colorectum | AD | carbohydrate homeostasis | 84/3918 | 259/18723 | 9.10e-06 | 2.15e-04 | 84 |
GO:0009746 | Colorectum | AD | response to hexose | 73/3918 | 219/18723 | 1.20e-05 | 2.65e-04 | 73 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0009749 | Colorectum | AD | response to glucose | 71/3918 | 212/18723 | 1.31e-05 | 2.85e-04 | 71 |
GO:0042593 | Colorectum | AD | glucose homeostasis | 83/3918 | 258/18723 | 1.44e-05 | 3.11e-04 | 83 |
GO:0001678 | Colorectum | AD | cellular glucose homeostasis | 60/3918 | 172/18723 | 1.49e-05 | 3.18e-04 | 60 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0071322 | Colorectum | AD | cellular response to carbohydrate stimulus | 56/3918 | 163/18723 | 4.61e-05 | 7.97e-04 | 56 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:0071333 | Colorectum | AD | cellular response to glucose stimulus | 52/3918 | 151/18723 | 7.88e-05 | 1.25e-03 | 52 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04213 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa042131 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa042132 | Colorectum | SER | Longevity regulating pathway - multiple species | 20/1580 | 62/8465 | 7.15e-03 | 3.77e-02 | 2.74e-02 | 20 |
hsa042133 | Colorectum | SER | Longevity regulating pathway - multiple species | 20/1580 | 62/8465 | 7.15e-03 | 3.77e-02 | 2.74e-02 | 20 |
hsa042134 | Colorectum | MSS | Longevity regulating pathway - multiple species | 27/1875 | 62/8465 | 1.33e-04 | 1.17e-03 | 7.18e-04 | 27 |
hsa042135 | Colorectum | MSS | Longevity regulating pathway - multiple species | 27/1875 | 62/8465 | 1.33e-04 | 1.17e-03 | 7.18e-04 | 27 |
hsa042138 | Liver | HCC | Longevity regulating pathway - multiple species | 41/4020 | 62/8465 | 2.30e-03 | 7.86e-03 | 4.37e-03 | 41 |
hsa0421311 | Liver | HCC | Longevity regulating pathway - multiple species | 41/4020 | 62/8465 | 2.30e-03 | 7.86e-03 | 4.37e-03 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXA2 | SNV | Missense_Mutation | novel | c.569N>G | p.Glu190Gly | p.E190G | Q9Y261 | protein_coding | deleterious(0) | possibly_damaging(0.506) | TCGA-P3-A5Q6-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FOXA2 | SNV | Missense_Mutation | c.368C>T | p.Ala123Val | p.A123V | Q9Y261 | protein_coding | tolerated(0.09) | possibly_damaging(0.537) | TCGA-EJ-5511-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
FOXA2 | SNV | Missense_Mutation | c.175N>G | p.Ser59Gly | p.S59G | Q9Y261 | protein_coding | tolerated(0.07) | benign(0.023) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FOXA2 | SNV | Missense_Mutation | c.250N>T | p.Ala84Ser | p.A84S | Q9Y261 | protein_coding | tolerated(0.12) | benign(0.038) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FOXA2 | insertion | Frame_Shift_Ins | novel | c.1206_1207insG | p.Pro403AlafsTer81 | p.P403Afs*81 | Q9Y261 | protein_coding | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FOXA2 | SNV | Missense_Mutation | novel | c.493N>G | p.Lys165Glu | p.K165E | Q9Y261 | protein_coding | deleterious(0) | possibly_damaging(0.696) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
FOXA2 | insertion | Frame_Shift_Ins | novel | c.493_494insGT | p.Lys165SerfsTer23 | p.K165Sfs*23 | Q9Y261 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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