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Gene: FBXO21 |
Gene summary for FBXO21 |
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Gene information | Species | Human | Gene symbol | FBXO21 | Gene ID | 23014 |
Gene name | F-box protein 21 | |
Gene Alias | FBX21 | |
Cytomap | 12q24.22 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024RBL8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23014 | FBXO21 | LZE4T | Human | Esophagus | ESCC | 5.66e-12 | 2.85e-01 | 0.0811 |
23014 | FBXO21 | LZE7T | Human | Esophagus | ESCC | 5.10e-10 | 5.87e-01 | 0.0667 |
23014 | FBXO21 | LZE8T | Human | Esophagus | ESCC | 1.10e-10 | 4.30e-01 | 0.067 |
23014 | FBXO21 | LZE20T | Human | Esophagus | ESCC | 1.42e-04 | 1.43e-01 | 0.0662 |
23014 | FBXO21 | LZE22D1 | Human | Esophagus | HGIN | 2.78e-03 | 1.87e-01 | 0.0595 |
23014 | FBXO21 | LZE22T | Human | Esophagus | ESCC | 5.80e-07 | 4.04e-01 | 0.068 |
23014 | FBXO21 | LZE24T | Human | Esophagus | ESCC | 1.01e-14 | 5.32e-01 | 0.0596 |
23014 | FBXO21 | LZE21T | Human | Esophagus | ESCC | 1.33e-03 | 2.36e-01 | 0.0655 |
23014 | FBXO21 | P1T-E | Human | Esophagus | ESCC | 9.71e-03 | 4.24e-01 | 0.0875 |
23014 | FBXO21 | P2T-E | Human | Esophagus | ESCC | 8.90e-83 | 1.20e+00 | 0.1177 |
23014 | FBXO21 | P4T-E | Human | Esophagus | ESCC | 3.83e-34 | 9.10e-01 | 0.1323 |
23014 | FBXO21 | P5T-E | Human | Esophagus | ESCC | 3.31e-12 | 3.12e-01 | 0.1327 |
23014 | FBXO21 | P8T-E | Human | Esophagus | ESCC | 7.46e-30 | 5.87e-01 | 0.0889 |
23014 | FBXO21 | P9T-E | Human | Esophagus | ESCC | 2.45e-11 | 2.58e-01 | 0.1131 |
23014 | FBXO21 | P10T-E | Human | Esophagus | ESCC | 1.82e-26 | 5.49e-01 | 0.116 |
23014 | FBXO21 | P11T-E | Human | Esophagus | ESCC | 4.32e-13 | 5.66e-01 | 0.1426 |
23014 | FBXO21 | P12T-E | Human | Esophagus | ESCC | 2.39e-25 | 5.94e-01 | 0.1122 |
23014 | FBXO21 | P15T-E | Human | Esophagus | ESCC | 5.58e-27 | 6.04e-01 | 0.1149 |
23014 | FBXO21 | P16T-E | Human | Esophagus | ESCC | 2.76e-29 | 6.46e-01 | 0.1153 |
23014 | FBXO21 | P17T-E | Human | Esophagus | ESCC | 4.73e-11 | 3.43e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO21 | SNV | Missense_Mutation | novel | c.1298N>G | p.Tyr433Cys | p.Y433C | O94952 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BA-4076-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FBXO21 | SNV | Missense_Mutation | novel | c.357G>C | p.Lys119Asn | p.K119N | O94952 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
FBXO21 | SNV | Missense_Mutation | novel | c.571N>A | p.Asp191Asn | p.D191N | O94952 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-CV-7418-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
FBXO21 | SNV | Missense_Mutation | novel | c.632N>G | p.Asp211Gly | p.D211G | O94952 | protein_coding | deleterious(0.01) | benign(0.135) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FBXO21 | SNV | Missense_Mutation | novel | c.1811N>G | p.Tyr604Cys | p.Y604C | O94952 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CV-A6JN-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FBXO21 | SNV | Missense_Mutation | novel | c.613T>C | p.Tyr205His | p.Y205H | O94952 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBXO21 | SNV | Missense_Mutation | novel | c.383N>A | p.Cys128Tyr | p.C128Y | O94952 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-EJ-A8FU-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
FBXO21 | SNV | Missense_Mutation | novel | c.1283T>G | p.Leu428Arg | p.L428R | O94952 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-ZG-A9NI-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
FBXO21 | SNV | Missense_Mutation | c.1256N>G | p.Tyr419Cys | p.Y419C | O94952 | protein_coding | tolerated(0.19) | probably_damaging(0.921) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FBXO21 | SNV | Missense_Mutation | c.331N>T | p.Arg111Trp | p.R111W | O94952 | protein_coding | deleterious(0) | possibly_damaging(0.551) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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