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Gene: FAN1 |
Gene summary for FAN1 |
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Gene information | Species | Human | Gene symbol | FAN1 | Gene ID | 22909 |
Gene name | FANCD2 and FANCI associated nuclease 1 | |
Gene Alias | KIAA1018 | |
Cytomap | 15q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q9Y2M0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22909 | FAN1 | HCC1_Meng | Human | Liver | HCC | 2.61e-21 | 4.08e-02 | 0.0246 |
22909 | FAN1 | HCC2_Meng | Human | Liver | HCC | 7.21e-08 | 5.80e-02 | 0.0107 |
22909 | FAN1 | HCC1 | Human | Liver | HCC | 1.37e-05 | 3.31e+00 | 0.5336 |
22909 | FAN1 | HCC2 | Human | Liver | HCC | 2.63e-09 | 2.97e+00 | 0.5341 |
22909 | FAN1 | S027 | Human | Liver | HCC | 4.52e-04 | 3.64e-01 | 0.2446 |
22909 | FAN1 | S029 | Human | Liver | HCC | 4.79e-02 | 2.67e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAN1 | SNV | Missense_Mutation | rs776135449 | c.2696G>A | p.Arg899Gln | p.R899Q | Q9Y2M0 | protein_coding | tolerated(0.59) | benign(0.017) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAN1 | SNV | Missense_Mutation | novel | c.173N>T | p.Arg58Leu | p.R58L | Q9Y2M0 | protein_coding | deleterious(0.01) | benign(0.103) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FAN1 | SNV | Missense_Mutation | novel | c.1538N>A | p.Gly513Asp | p.G513D | Q9Y2M0 | protein_coding | tolerated(0.08) | probably_damaging(0.945) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FAN1 | SNV | Missense_Mutation | novel | c.1770N>A | p.Asn590Lys | p.N590K | Q9Y2M0 | protein_coding | deleterious(0.01) | benign(0.164) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FAN1 | SNV | Missense_Mutation | novel | c.1999N>G | p.Thr667Ala | p.T667A | Q9Y2M0 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FAN1 | SNV | Missense_Mutation | c.2402N>T | p.Ala801Val | p.A801V | Q9Y2M0 | protein_coding | tolerated(0.18) | benign(0.164) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
FAN1 | SNV | Missense_Mutation | novel | c.86N>A | p.Ser29Tyr | p.S29Y | Q9Y2M0 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAN1 | SNV | Missense_Mutation | novel | c.1415N>G | p.Leu472Arg | p.L472R | Q9Y2M0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAN1 | SNV | Missense_Mutation | c.2090N>T | p.Arg697Ile | p.R697I | Q9Y2M0 | protein_coding | deleterious(0.04) | benign(0.065) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAN1 | SNV | Missense_Mutation | novel | c.859G>A | p.Glu287Lys | p.E287K | Q9Y2M0 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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