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Gene: ENGASE |
Gene summary for ENGASE |
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Gene information | Species | Human | Gene symbol | ENGASE | Gene ID | 64772 |
Gene name | endo-beta-N-acetylglucosaminidase | |
Gene Alias | ENGASE | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q8NFI3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64772 | ENGASE | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.91e-03 | 1.51e-01 | 0.0155 |
64772 | ENGASE | HTA11_866_3004761011 | Human | Colorectum | AD | 5.44e-07 | 3.42e-01 | 0.096 |
64772 | ENGASE | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.30e-02 | 2.23e-01 | 0.0674 |
64772 | ENGASE | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.14e-08 | 5.50e-01 | 0.3859 |
64772 | ENGASE | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.04e-10 | 5.71e-01 | 0.3005 |
64772 | ENGASE | A015-C-203 | Human | Colorectum | FAP | 1.38e-07 | 3.43e-01 | -0.1294 |
64772 | ENGASE | A002-C-201 | Human | Colorectum | FAP | 1.12e-08 | 5.54e-01 | 0.0324 |
64772 | ENGASE | A002-C-203 | Human | Colorectum | FAP | 1.21e-03 | 3.82e-01 | 0.2786 |
64772 | ENGASE | A002-C-021 | Human | Colorectum | FAP | 6.84e-06 | 3.61e-01 | 0.1171 |
64772 | ENGASE | A002-C-205 | Human | Colorectum | FAP | 1.19e-02 | 2.55e-01 | -0.1236 |
64772 | ENGASE | A002-C-114 | Human | Colorectum | FAP | 4.53e-04 | 3.67e-01 | -0.1561 |
64772 | ENGASE | A015-C-104 | Human | Colorectum | FAP | 5.24e-03 | 2.22e-01 | -0.1899 |
64772 | ENGASE | A015-C-202 | Human | Colorectum | FAP | 7.51e-05 | 3.80e-01 | -0.0849 |
64772 | ENGASE | A002-C-116 | Human | Colorectum | FAP | 3.81e-03 | 3.23e-02 | -0.0452 |
64772 | ENGASE | A014-C-008 | Human | Colorectum | FAP | 2.34e-04 | 4.36e-01 | -0.191 |
64772 | ENGASE | CRC-1-8810 | Human | Colorectum | CRC | 2.11e-06 | 5.34e-01 | 0.6257 |
64772 | ENGASE | CRC-3-11773 | Human | Colorectum | CRC | 5.11e-11 | 5.34e-01 | 0.2564 |
64772 | ENGASE | LZE24T | Human | Esophagus | ESCC | 1.88e-05 | 1.07e-01 | 0.0596 |
64772 | ENGASE | P1T-E | Human | Esophagus | ESCC | 1.89e-02 | 1.29e-01 | 0.0875 |
64772 | ENGASE | P2T-E | Human | Esophagus | ESCC | 9.38e-09 | 1.45e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:00064572 | Colorectum | MSS | protein folding | 71/3467 | 212/18723 | 1.25e-07 | 5.91e-06 | 71 |
GO:00064574 | Colorectum | FAP | protein folding | 44/2622 | 212/18723 | 4.36e-03 | 2.98e-02 | 44 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00065173 | Esophagus | ESCC | protein deglycosylation | 19/8552 | 26/18723 | 4.31e-03 | 1.71e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENGASE | SNV | Missense_Mutation | c.873G>T | p.Arg291Ser | p.R291S | Q8NFI3 | protein_coding | deleterious(0.03) | benign(0.338) | TCGA-G3-A25Z-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENGASE | insertion | In_Frame_Ins | novel | c.1271_1272insGTACCACCTGAGCGCCCAGGAGATCCAGCCCTT | p.Tyr425_Leu435dup | p.Y425_L435dup | Q8NFI3 | protein_coding | TCGA-G3-A25U-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ENGASE | deletion | Frame_Shift_Del | novel | c.1586_1587delNN | p.Leu529Ter | p.L529* | Q8NFI3 | protein_coding | TCGA-G3-A25Y-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
ENGASE | SNV | Missense_Mutation | novel | c.793G>T | p.Gly265Trp | p.G265W | Q8NFI3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENGASE | SNV | Missense_Mutation | c.887N>T | p.Ser296Phe | p.S296F | Q8NFI3 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-55-7283-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PR | |
ENGASE | SNV | Missense_Mutation | novel | c.781C>T | p.Arg261Trp | p.R261W | Q8NFI3 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-55-A48X-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ENGASE | SNV | Missense_Mutation | c.2062N>T | p.Gly688Trp | p.G688W | Q8NFI3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENGASE | SNV | Missense_Mutation | c.2192N>T | p.Glu731Val | p.E731V | Q8NFI3 | protein_coding | tolerated(0.08) | benign(0.23) | TCGA-73-4670-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
ENGASE | SNV | Missense_Mutation | novel | c.1772G>C | p.Ser591Thr | p.S591T | Q8NFI3 | protein_coding | tolerated(0.08) | benign(0.096) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ENGASE | SNV | Missense_Mutation | rs547678422 | c.853N>A | p.Glu285Lys | p.E285K | Q8NFI3 | protein_coding | tolerated(0.07) | possibly_damaging(0.876) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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