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Gene: ENC1 |
Gene summary for ENC1 |
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Gene information | Species | Human | Gene symbol | ENC1 | Gene ID | 8507 |
Gene name | ectodermal-neural cortex 1 | |
Gene Alias | CCL28 | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | O14682 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8507 | ENC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.74e-11 | 7.33e-01 | 0.281 |
8507 | ENC1 | F007 | Human | Colorectum | FAP | 4.95e-06 | 6.38e-01 | 0.1176 |
8507 | ENC1 | A002-C-010 | Human | Colorectum | FAP | 1.67e-03 | 3.26e-01 | 0.242 |
8507 | ENC1 | A001-C-207 | Human | Colorectum | FAP | 1.79e-07 | 6.09e-01 | 0.1278 |
8507 | ENC1 | A015-C-203 | Human | Colorectum | FAP | 8.36e-35 | 8.76e-01 | -0.1294 |
8507 | ENC1 | A015-C-204 | Human | Colorectum | FAP | 2.51e-12 | 7.00e-01 | -0.0228 |
8507 | ENC1 | A014-C-040 | Human | Colorectum | FAP | 2.34e-04 | 6.43e-01 | -0.1184 |
8507 | ENC1 | A002-C-201 | Human | Colorectum | FAP | 9.78e-16 | 6.55e-01 | 0.0324 |
8507 | ENC1 | A002-C-203 | Human | Colorectum | FAP | 9.09e-10 | 5.88e-01 | 0.2786 |
8507 | ENC1 | A001-C-108 | Human | Colorectum | FAP | 1.97e-18 | 6.47e-01 | -0.0272 |
8507 | ENC1 | A002-C-021 | Human | Colorectum | FAP | 2.29e-08 | 4.05e-01 | 0.1171 |
8507 | ENC1 | A002-C-205 | Human | Colorectum | FAP | 2.58e-14 | 5.19e-01 | -0.1236 |
8507 | ENC1 | A001-C-104 | Human | Colorectum | FAP | 1.92e-14 | 6.19e-01 | 0.0184 |
8507 | ENC1 | A015-C-005 | Human | Colorectum | FAP | 4.09e-04 | 4.67e-01 | -0.0336 |
8507 | ENC1 | A015-C-006 | Human | Colorectum | FAP | 3.06e-15 | 6.83e-01 | -0.0994 |
8507 | ENC1 | A015-C-106 | Human | Colorectum | FAP | 2.67e-22 | 7.69e-01 | -0.0511 |
8507 | ENC1 | A002-C-114 | Human | Colorectum | FAP | 1.87e-04 | 2.00e-01 | -0.1561 |
8507 | ENC1 | A015-C-104 | Human | Colorectum | FAP | 5.02e-31 | 7.96e-01 | -0.1899 |
8507 | ENC1 | A001-C-014 | Human | Colorectum | FAP | 1.63e-13 | 6.56e-01 | 0.0135 |
8507 | ENC1 | A002-C-016 | Human | Colorectum | FAP | 1.29e-06 | 3.47e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:0017148 | Colorectum | MSS | negative regulation of translation | 64/3467 | 245/18723 | 1.94e-03 | 1.67e-02 | 64 |
GO:0034249 | Colorectum | MSS | negative regulation of cellular amide metabolic process | 70/3467 | 273/18723 | 2.07e-03 | 1.76e-02 | 70 |
GO:00064174 | Colorectum | FAP | regulation of translation | 111/2622 | 468/18723 | 8.47e-09 | 1.13e-06 | 111 |
GO:00109753 | Colorectum | FAP | regulation of neuron projection development | 102/2622 | 445/18723 | 2.04e-07 | 1.24e-05 | 102 |
GO:00104984 | Colorectum | FAP | proteasomal protein catabolic process | 110/2622 | 490/18723 | 2.12e-07 | 1.26e-05 | 110 |
GO:00313463 | Colorectum | FAP | positive regulation of cell projection organization | 82/2622 | 353/18723 | 1.78e-06 | 7.35e-05 | 82 |
GO:00171481 | Colorectum | FAP | negative regulation of translation | 50/2622 | 245/18723 | 3.57e-03 | 2.57e-02 | 50 |
GO:00342491 | Colorectum | FAP | negative regulation of cellular amide metabolic process | 54/2622 | 273/18723 | 5.00e-03 | 3.33e-02 | 54 |
GO:00109754 | Colorectum | CRC | regulation of neuron projection development | 82/2078 | 445/18723 | 2.51e-06 | 1.19e-04 | 82 |
GO:00313464 | Colorectum | CRC | positive regulation of cell projection organization | 67/2078 | 353/18723 | 7.45e-06 | 2.72e-04 | 67 |
GO:00064175 | Colorectum | CRC | regulation of translation | 82/2078 | 468/18723 | 1.79e-05 | 5.40e-04 | 82 |
GO:00104985 | Colorectum | CRC | proteasomal protein catabolic process | 77/2078 | 490/18723 | 1.03e-03 | 1.21e-02 | 77 |
GO:00342492 | Colorectum | CRC | negative regulation of cellular amide metabolic process | 45/2078 | 273/18723 | 4.35e-03 | 3.47e-02 | 45 |
GO:00171482 | Colorectum | CRC | negative regulation of translation | 41/2078 | 245/18723 | 4.82e-03 | 3.72e-02 | 41 |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENC1 | deletion | Frame_Shift_Del | c.1496delG | p.Gly499ValfsTer26 | p.G499Vfs*26 | O14682 | protein_coding | TCGA-D1-A17H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
ENC1 | SNV | Missense_Mutation | c.1088N>G | p.Thr363Ser | p.T363S | O14682 | protein_coding | tolerated(0.91) | benign(0.369) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
ENC1 | SNV | Missense_Mutation | c.1077N>T | p.Trp359Cys | p.W359C | O14682 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7148-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ENC1 | SNV | Missense_Mutation | rs61758147 | c.674N>A | p.Arg225His | p.R225H | O14682 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-86-8056-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ENC1 | SNV | Missense_Mutation | c.1171N>A | p.Tyr391Asn | p.Y391N | O14682 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENC1 | SNV | Missense_Mutation | novel | c.208N>C | p.Tyr70His | p.Y70H | O14682 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-33-AASI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | PD |
ENC1 | SNV | Missense_Mutation | novel | c.848N>A | p.Val283Glu | p.V283E | O14682 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
ENC1 | SNV | Missense_Mutation | novel | c.484N>T | p.Thr162Ser | p.T162S | O14682 | protein_coding | tolerated(0.37) | benign(0.027) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
ENC1 | SNV | Missense_Mutation | novel | c.781N>C | p.Lys261Gln | p.K261Q | O14682 | protein_coding | tolerated(0.47) | benign(0.005) | TCGA-66-2780-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ENC1 | SNV | Missense_Mutation | rs866443122 | c.356N>T | p.Ser119Leu | p.S119L | O14682 | protein_coding | tolerated(0.64) | possibly_damaging(0.876) | TCGA-77-8154-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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