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Gene: EML2 |
Gene summary for EML2 |
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Gene information | Species | Human | Gene symbol | EML2 | Gene ID | 24139 |
Gene name | EMAP like 2 | |
Gene Alias | ELP70 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O95834 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
24139 | EML2 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.68e-09 | 4.34e-01 | -0.1954 |
24139 | EML2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.22e-06 | 4.74e-01 | -0.1526 |
24139 | EML2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.67e-09 | 4.81e-01 | -0.1464 |
24139 | EML2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.49e-09 | 5.85e-01 | -0.059 |
24139 | EML2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.82e-14 | 5.36e-01 | 0.0674 |
24139 | EML2 | A015-C-203 | Human | Colorectum | FAP | 1.34e-08 | -1.56e-01 | -0.1294 |
24139 | EML2 | A001-C-108 | Human | Colorectum | FAP | 3.00e-03 | -1.36e-01 | -0.0272 |
24139 | EML2 | A002-C-205 | Human | Colorectum | FAP | 2.35e-04 | -1.98e-01 | -0.1236 |
24139 | EML2 | A015-C-104 | Human | Colorectum | FAP | 1.60e-11 | -2.41e-01 | -0.1899 |
24139 | EML2 | A001-C-014 | Human | Colorectum | FAP | 4.77e-03 | -1.04e-01 | 0.0135 |
24139 | EML2 | A002-C-016 | Human | Colorectum | FAP | 1.51e-06 | -1.75e-01 | 0.0521 |
24139 | EML2 | A015-C-002 | Human | Colorectum | FAP | 3.72e-02 | -2.34e-01 | -0.0763 |
24139 | EML2 | A001-C-203 | Human | Colorectum | FAP | 2.70e-02 | -1.73e-01 | -0.0481 |
24139 | EML2 | A002-C-116 | Human | Colorectum | FAP | 1.02e-08 | -2.21e-01 | -0.0452 |
24139 | EML2 | A018-E-020 | Human | Colorectum | FAP | 1.94e-03 | -1.80e-01 | -0.2034 |
24139 | EML2 | F034 | Human | Colorectum | FAP | 2.60e-05 | -1.42e-01 | -0.0665 |
24139 | EML2 | F072B | Human | Colorectum | FAP | 7.06e-03 | -1.81e-01 | 0.257 |
24139 | EML2 | CRC-3-11773 | Human | Colorectum | CRC | 3.63e-02 | -1.57e-01 | 0.2564 |
24139 | EML2 | LZE2T | Human | Esophagus | ESCC | 3.85e-03 | 2.37e-01 | 0.082 |
24139 | EML2 | LZE4T | Human | Esophagus | ESCC | 1.12e-14 | 4.90e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0032272 | Colorectum | AD | negative regulation of protein polymerization | 36/3918 | 80/18723 | 1.13e-06 | 3.72e-05 | 36 |
GO:1902904 | Colorectum | AD | negative regulation of supramolecular fiber organization | 60/3918 | 167/18723 | 5.23e-06 | 1.35e-04 | 60 |
GO:0031333 | Colorectum | AD | negative regulation of protein-containing complex assembly | 52/3918 | 141/18723 | 9.27e-06 | 2.18e-04 | 52 |
GO:0051494 | Colorectum | AD | negative regulation of cytoskeleton organization | 58/3918 | 163/18723 | 1.04e-05 | 2.40e-04 | 58 |
GO:0070507 | Colorectum | AD | regulation of microtubule cytoskeleton organization | 44/3918 | 148/18723 | 7.05e-03 | 4.31e-02 | 44 |
GO:19029031 | Colorectum | SER | regulation of supramolecular fiber organization | 114/2897 | 383/18723 | 7.32e-13 | 1.95e-10 | 114 |
GO:00322711 | Colorectum | SER | regulation of protein polymerization | 78/2897 | 233/18723 | 5.71e-12 | 1.17e-09 | 78 |
GO:00512581 | Colorectum | SER | protein polymerization | 91/2897 | 297/18723 | 2.72e-11 | 5.06e-09 | 91 |
GO:00432541 | Colorectum | SER | regulation of protein-containing complex assembly | 119/2897 | 428/18723 | 3.34e-11 | 5.86e-09 | 119 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00322721 | Colorectum | SER | negative regulation of protein polymerization | 31/2897 | 80/18723 | 3.67e-07 | 1.96e-05 | 31 |
GO:19029041 | Colorectum | SER | negative regulation of supramolecular fiber organization | 50/2897 | 167/18723 | 1.63e-06 | 7.23e-05 | 50 |
GO:00514941 | Colorectum | SER | negative regulation of cytoskeleton organization | 48/2897 | 163/18723 | 4.34e-06 | 1.63e-04 | 48 |
GO:00313331 | Colorectum | SER | negative regulation of protein-containing complex assembly | 43/2897 | 141/18723 | 5.03e-06 | 1.86e-04 | 43 |
GO:00432544 | Colorectum | FAP | regulation of protein-containing complex assembly | 101/2622 | 428/18723 | 5.18e-08 | 4.07e-06 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EML2 | SNV | Missense_Mutation | novel | c.1082N>C | p.Arg361Thr | p.R361T | O95834 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EML2 | SNV | Missense_Mutation | c.2089G>T | p.Val697Phe | p.V697F | O95834 | protein_coding | tolerated(0.06) | possibly_damaging(0.885) | TCGA-HC-A6AO-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
EML2 | SNV | Missense_Mutation | novel | c.1753N>A | p.Ala585Thr | p.A585T | O95834 | protein_coding | deleterious(0.02) | possibly_damaging(0.572) | TCGA-HC-A9TE-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | eligard | SD |
EML2 | SNV | Missense_Mutation | c.2240C>T | p.Ala747Val | p.A747V | O95834 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EML2 | SNV | Missense_Mutation | c.680G>A | p.Arg227Lys | p.R227K | O95834 | protein_coding | tolerated(0.08) | benign(0.049) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EML2 | SNV | Missense_Mutation | c.2300T>A | p.Ile767Asn | p.I767N | O95834 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EML2 | SNV | Missense_Mutation | novel | c.2113N>T | p.Gly705Cys | p.G705C | O95834 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-8533-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | capecitabine | PD |
EML2 | SNV | Missense_Mutation | c.1573G>A | p.Asp525Asn | p.D525N | O95834 | protein_coding | tolerated(0.45) | probably_damaging(0.995) | TCGA-CD-A487-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | CR | |
EML2 | SNV | Missense_Mutation | c.1748N>A | p.Gly583Asp | p.G583D | O95834 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
EML2 | SNV | Missense_Mutation | novel | c.1458C>G | p.Ile486Met | p.I486M | O95834 | protein_coding | deleterious(0.01) | possibly_damaging(0.804) | TCGA-VQ-AA64-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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