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Gene: DPCR1 |
Gene summary for DPCR1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DPCR1 | Gene ID | 135656 |
| Gene name | mucin like 3 | |
| Gene Alias | C6orf37 | |
| Cytomap | 6p21.33 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | E9PEI6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 135656 | DPCR1 | Pat01-B | Human | Stomach | GC | 4.57e-15 | -6.21e-01 | 0.5754 |
| 135656 | DPCR1 | Pat02-B | Human | Stomach | GC | 3.11e-14 | -6.21e-01 | 0.0368 |
| 135656 | DPCR1 | Pat03-B | Human | Stomach | GC | 1.62e-12 | -6.21e-01 | 0.3693 |
| 135656 | DPCR1 | Pat04-B | Human | Stomach | GC | 2.00e-05 | -6.21e-01 | -0.1483 |
| 135656 | DPCR1 | Pat05-B | Human | Stomach | GC | 7.89e-05 | -6.21e-01 | -0.0353 |
| 135656 | DPCR1 | Pat06-B | Human | Stomach | GC | 1.81e-12 | -6.21e-01 | -0.1961 |
| 135656 | DPCR1 | Pat07-B | Human | Stomach | GC | 4.67e-02 | -6.21e-01 | 0.0935 |
| 135656 | DPCR1 | Pat08-B | Human | Stomach | GC | 8.41e-04 | -6.21e-01 | 0.0182 |
| 135656 | DPCR1 | Pat09-B | Human | Stomach | GC | 2.25e-10 | -6.21e-01 | -0.0359 |
| 135656 | DPCR1 | Pat11-B | Human | Stomach | GC | 3.78e-04 | -6.21e-01 | -0.182 |
| 135656 | DPCR1 | Pat12-B | Human | Stomach | GC | 1.29e-13 | -6.21e-01 | 0.0325 |
| 135656 | DPCR1 | Pat13-B | Human | Stomach | GC | 1.89e-06 | -6.21e-01 | 0.0555 |
| 135656 | DPCR1 | Pat15-B | Human | Stomach | GC | 2.88e-10 | -6.21e-01 | -0.0778 |
| 135656 | DPCR1 | Pat16-B | Human | Stomach | GC | 3.11e-14 | -6.21e-01 | 0.1918 |
| 135656 | DPCR1 | Pat17-B | Human | Stomach | GC | 6.94e-14 | -6.21e-01 | 0.3109 |
| 135656 | DPCR1 | Pat18-B | Human | Stomach | GC | 8.98e-12 | -6.21e-01 | -0.0432 |
| 135656 | DPCR1 | Pat19-B | Human | Stomach | GC | 2.24e-08 | -6.21e-01 | 0.0826 |
| 135656 | DPCR1 | Pat22-B | Human | Stomach | GC | 9.58e-11 | -6.21e-01 | -0.1042 |
| 135656 | DPCR1 | Pat24-B | Human | Stomach | GC | 2.53e-06 | -6.21e-01 | -0.1184 |
| 135656 | DPCR1 | Pat25-A | Human | Stomach | CAG with IM | 6.94e-14 | -6.21e-01 | -0.1648 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DPCR1 | SNV | Missense_Mutation | c.254G>A | p.Arg85His | p.R85H | protein_coding | tolerated(0.3) | benign(0.044) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| DPCR1 | SNV | Missense_Mutation | novel | c.1946C>T | p.Ala649Val | p.A649V | protein_coding | tolerated(0.1) | possibly_damaging(0.661) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.1723N>T | p.Pro575Ser | p.P575S | protein_coding | tolerated(0.45) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.2073N>T | p.Glu691Asp | p.E691D | protein_coding | tolerated(0.47) | benign(0.042) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.657N>T | p.Lys219Asn | p.K219N | protein_coding | tolerated(1) | benign(0) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.751N>T | p.Asp251Tyr | p.D251Y | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.1533N>C | p.Lys511Asn | p.K511N | protein_coding | tolerated(0.13) | benign(0.207) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | c.3699N>C | p.Glu1233Asp | p.E1233D | protein_coding | tolerated(0.38) | possibly_damaging(0.851) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| DPCR1 | SNV | Missense_Mutation | novel | c.3105N>G | p.Ile1035Met | p.I1035M | protein_coding | tolerated(0.06) | possibly_damaging(0.805) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.259N>C | p.Cys87Arg | p.C87R | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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