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Gene: DMBX1 |
Gene summary for DMBX1 |
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Gene information | Species | Human | Gene symbol | DMBX1 | Gene ID | 127343 |
Gene name | diencephalon/mesencephalon homeobox 1 | |
Gene Alias | MBX | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8NFW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
127343 | DMBX1 | HCC2 | Human | Liver | HCC | 2.33e-16 | 1.18e+00 | 0.5341 |
127343 | DMBX1 | HCC5 | Human | Liver | HCC | 5.98e-15 | 1.11e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMBX1 | SNV | Missense_Mutation | c.730C>T | p.Leu244Phe | p.L244F | Q8NFW5 | protein_coding | tolerated_low_confidence(0.71) | benign(0.205) | TCGA-EJ-5496-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
DMBX1 | SNV | Missense_Mutation | c.359A>C | p.Lys120Thr | p.K120T | Q8NFW5 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-HC-A4ZV-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
DMBX1 | SNV | Missense_Mutation | c.483N>T | p.Gln161His | p.Q161H | Q8NFW5 | protein_coding | tolerated(0.11) | possibly_damaging(0.735) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DMBX1 | SNV | Missense_Mutation | rs760474949 | c.857N>T | p.Pro286Leu | p.P286L | Q8NFW5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.932) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
DMBX1 | SNV | Missense_Mutation | c.887N>T | p.Ala296Val | p.A296V | Q8NFW5 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.487) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
DMBX1 | SNV | Missense_Mutation | rs763846022 | c.191N>A | p.Arg64His | p.R64H | Q8NFW5 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
DMBX1 | deletion | Frame_Shift_Del | novel | c.101delN | p.Asp36ThrfsTer59 | p.D36Tfs*59 | Q8NFW5 | protein_coding | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DMBX1 | deletion | Frame_Shift_Del | rs780624487 | c.484delN | p.Pro163HisfsTer14 | p.P163Hfs*14 | Q8NFW5 | protein_coding | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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