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Gene: DLGAP5 |
Gene summary for DLGAP5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DLGAP5 | Gene ID | 9787 |
Gene name | DLG associated protein 5 | |
Gene Alias | DLG7 | |
Cytomap | 14q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q15398 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9787 | DLGAP5 | P2T-E | Human | Esophagus | ESCC | 4.17e-05 | 2.95e-01 | 0.1177 |
9787 | DLGAP5 | P4T-E | Human | Esophagus | ESCC | 3.48e-08 | 3.22e-01 | 0.1323 |
9787 | DLGAP5 | P5T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.91e-01 | 0.1327 |
9787 | DLGAP5 | P9T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.56e-01 | 0.1131 |
9787 | DLGAP5 | P10T-E | Human | Esophagus | ESCC | 8.84e-05 | 2.60e-01 | 0.116 |
9787 | DLGAP5 | P15T-E | Human | Esophagus | ESCC | 3.38e-04 | 3.10e-01 | 0.1149 |
9787 | DLGAP5 | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 4.01e-01 | 0.1278 |
9787 | DLGAP5 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 5.72e-01 | 0.1662 |
9787 | DLGAP5 | P20T-E | Human | Esophagus | ESCC | 1.51e-02 | 1.78e-01 | 0.1124 |
9787 | DLGAP5 | P21T-E | Human | Esophagus | ESCC | 4.31e-06 | 2.54e-01 | 0.1617 |
9787 | DLGAP5 | P24T-E | Human | Esophagus | ESCC | 3.60e-13 | 4.44e-01 | 0.1287 |
9787 | DLGAP5 | P26T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.85e-01 | 0.1276 |
9787 | DLGAP5 | P28T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.61e-02 | 0.1149 |
9787 | DLGAP5 | P30T-E | Human | Esophagus | ESCC | 1.02e-02 | 3.43e-01 | 0.137 |
9787 | DLGAP5 | P31T-E | Human | Esophagus | ESCC | 1.96e-05 | 2.52e-01 | 0.1251 |
9787 | DLGAP5 | P32T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.93e-01 | 0.1666 |
9787 | DLGAP5 | P36T-E | Human | Esophagus | ESCC | 2.11e-03 | 2.27e-01 | 0.1187 |
9787 | DLGAP5 | P37T-E | Human | Esophagus | ESCC | 4.26e-12 | 5.49e-01 | 0.1371 |
9787 | DLGAP5 | P38T-E | Human | Esophagus | ESCC | 1.30e-06 | 4.85e-01 | 0.127 |
9787 | DLGAP5 | P42T-E | Human | Esophagus | ESCC | 2.93e-03 | 2.26e-01 | 0.1175 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:00519833 | Esophagus | ESCC | regulation of chromosome segregation | 67/8552 | 91/18723 | 5.42e-08 | 9.66e-07 | 67 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DLGAP5 | SNV | Missense_Mutation | c.797N>A | p.Ser266Asn | p.S266N | Q15398 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP5 | SNV | Missense_Mutation | c.1751G>C | p.Arg584Thr | p.R584T | Q15398 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
DLGAP5 | SNV | Missense_Mutation | c.2172G>T | p.Met724Ile | p.M724I | Q15398 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-39-5028-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
DLGAP5 | SNV | Missense_Mutation | novel | c.1546N>A | p.Gln516Lys | p.Q516K | Q15398 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-43-6771-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DLGAP5 | SNV | Missense_Mutation | c.38A>T | p.Asp13Val | p.D13V | Q15398 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP5 | SNV | Missense_Mutation | novel | c.1809A>C | p.Glu603Asp | p.E603D | Q15398 | protein_coding | tolerated(0.1) | possibly_damaging(0.761) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DLGAP5 | SNV | Missense_Mutation | novel | c.1170N>A | p.His390Gln | p.H390Q | Q15398 | protein_coding | tolerated(0.19) | benign(0.167) | TCGA-56-8308-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | SD |
DLGAP5 | SNV | Missense_Mutation | novel | c.1659N>T | p.Lys553Asn | p.K553N | Q15398 | protein_coding | deleterious(0.03) | benign(0.084) | TCGA-56-8629-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
DLGAP5 | SNV | Missense_Mutation | c.2172N>C | p.Met724Ile | p.M724I | Q15398 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-56-A4ZK-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP5 | SNV | Missense_Mutation | novel | c.667N>T | p.Thr223Ser | p.T223S | Q15398 | protein_coding | tolerated(0.16) | benign(0.127) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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