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Gene: DENND2C |
Gene summary for DENND2C |
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Gene information | Species | Human | Gene symbol | DENND2C | Gene ID | 163259 |
Gene name | DENN domain containing 2C | |
Gene Alias | dJ1156J9.1 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q68D51 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
163259 | DENND2C | CA_HPV_2 | Human | Cervix | CC | 1.19e-05 | 3.75e-01 | 0.0391 |
163259 | DENND2C | CCI_1 | Human | Cervix | CC | 4.53e-24 | 1.82e+00 | 0.528 |
163259 | DENND2C | CCI_2 | Human | Cervix | CC | 2.13e-02 | 4.03e-01 | 0.5249 |
163259 | DENND2C | CCI_3 | Human | Cervix | CC | 4.63e-12 | 8.12e-01 | 0.516 |
163259 | DENND2C | sample3 | Human | Cervix | CC | 4.10e-10 | 3.21e-01 | 0.1387 |
163259 | DENND2C | T1 | Human | Cervix | CC | 3.11e-02 | 1.96e-01 | 0.0918 |
163259 | DENND2C | T3 | Human | Cervix | CC | 1.06e-13 | 3.47e-01 | 0.1389 |
163259 | DENND2C | LZE4T | Human | Esophagus | ESCC | 3.24e-14 | 3.96e-01 | 0.0811 |
163259 | DENND2C | LZE7T | Human | Esophagus | ESCC | 9.82e-05 | 2.65e-01 | 0.0667 |
163259 | DENND2C | LZE8T | Human | Esophagus | ESCC | 2.37e-02 | 1.79e-01 | 0.067 |
163259 | DENND2C | LZE20T | Human | Esophagus | ESCC | 3.55e-04 | 1.75e-01 | 0.0662 |
163259 | DENND2C | LZE24T | Human | Esophagus | ESCC | 2.39e-09 | 3.75e-01 | 0.0596 |
163259 | DENND2C | LZE21T | Human | Esophagus | ESCC | 4.73e-03 | 4.80e-01 | 0.0655 |
163259 | DENND2C | P1T-E | Human | Esophagus | ESCC | 5.98e-10 | 6.51e-01 | 0.0875 |
163259 | DENND2C | P2T-E | Human | Esophagus | ESCC | 3.44e-10 | 8.73e-02 | 0.1177 |
163259 | DENND2C | P4T-E | Human | Esophagus | ESCC | 1.68e-05 | 2.05e-01 | 0.1323 |
163259 | DENND2C | P5T-E | Human | Esophagus | ESCC | 7.31e-20 | 4.90e-01 | 0.1327 |
163259 | DENND2C | P8T-E | Human | Esophagus | ESCC | 6.01e-04 | 1.08e-01 | 0.0889 |
163259 | DENND2C | P9T-E | Human | Esophagus | ESCC | 5.17e-21 | 5.83e-01 | 0.1131 |
163259 | DENND2C | P10T-E | Human | Esophagus | ESCC | 3.65e-03 | 1.65e-02 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DENND2C | SNV | Missense_Mutation | rs189506550 | c.842N>A | p.Arg281Gln | p.R281Q | Q68D51 | protein_coding | tolerated(0.42) | probably_damaging(0.996) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DENND2C | SNV | Missense_Mutation | c.44N>T | p.Arg15Ile | p.R15I | Q68D51 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DENND2C | SNV | Missense_Mutation | c.2717C>T | p.Ser906Leu | p.S906L | Q68D51 | protein_coding | tolerated(0.06) | benign(0.173) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
DENND2C | SNV | Missense_Mutation | rs760763399 | c.556G>A | p.Gly186Arg | p.G186R | Q68D51 | protein_coding | tolerated(0.61) | benign(0.015) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DENND2C | SNV | Missense_Mutation | c.487A>C | p.Asn163His | p.N163H | Q68D51 | protein_coding | tolerated(0.16) | benign(0.332) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
DENND2C | SNV | Missense_Mutation | c.2455T>C | p.Ser819Pro | p.S819P | Q68D51 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DENND2C | SNV | Missense_Mutation | rs376157870 | c.1709G>A | p.Arg570Gln | p.R570Q | Q68D51 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DENND2C | SNV | Missense_Mutation | c.95C>T | p.Ala32Val | p.A32V | Q68D51 | protein_coding | deleterious(0.04) | benign(0.031) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DENND2C | SNV | Missense_Mutation | c.1585G>T | p.Asp529Tyr | p.D529Y | Q68D51 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
DENND2C | SNV | Missense_Mutation | rs200716799 | c.1373G>A | p.Arg458His | p.R458H | Q68D51 | protein_coding | tolerated(1) | benign(0.026) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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