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Gene: DDX50 |
Gene summary for DDX50 |
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Gene information | Species | Human | Gene symbol | DDX50 | Gene ID | 79009 |
Gene name | DExD-box helicase 50 | |
Gene Alias | GU2 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BQ39 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79009 | DDX50 | LZE4T | Human | Esophagus | ESCC | 4.58e-14 | 2.96e-01 | 0.0811 |
79009 | DDX50 | LZE5T | Human | Esophagus | ESCC | 1.92e-06 | 3.40e-01 | 0.0514 |
79009 | DDX50 | LZE7T | Human | Esophagus | ESCC | 2.92e-07 | 2.76e-01 | 0.0667 |
79009 | DDX50 | LZE8T | Human | Esophagus | ESCC | 2.43e-05 | 1.90e-01 | 0.067 |
79009 | DDX50 | LZE20T | Human | Esophagus | ESCC | 2.79e-05 | 1.86e-01 | 0.0662 |
79009 | DDX50 | LZE22D1 | Human | Esophagus | HGIN | 1.82e-09 | 2.34e-01 | 0.0595 |
79009 | DDX50 | LZE22T | Human | Esophagus | ESCC | 6.08e-04 | 3.91e-01 | 0.068 |
79009 | DDX50 | LZE24T | Human | Esophagus | ESCC | 1.89e-23 | 4.91e-01 | 0.0596 |
79009 | DDX50 | LZE6T | Human | Esophagus | ESCC | 8.69e-09 | 2.51e-01 | 0.0845 |
79009 | DDX50 | P1T-E | Human | Esophagus | ESCC | 5.87e-15 | 5.95e-01 | 0.0875 |
79009 | DDX50 | P2T-E | Human | Esophagus | ESCC | 1.81e-45 | 8.47e-01 | 0.1177 |
79009 | DDX50 | P4T-E | Human | Esophagus | ESCC | 2.03e-27 | 6.21e-01 | 0.1323 |
79009 | DDX50 | P5T-E | Human | Esophagus | ESCC | 5.23e-24 | 4.30e-01 | 0.1327 |
79009 | DDX50 | P8T-E | Human | Esophagus | ESCC | 5.57e-24 | 4.10e-01 | 0.0889 |
79009 | DDX50 | P9T-E | Human | Esophagus | ESCC | 2.61e-16 | 3.27e-01 | 0.1131 |
79009 | DDX50 | P10T-E | Human | Esophagus | ESCC | 1.20e-25 | 4.69e-01 | 0.116 |
79009 | DDX50 | P11T-E | Human | Esophagus | ESCC | 6.93e-20 | 3.53e-01 | 0.1426 |
79009 | DDX50 | P12T-E | Human | Esophagus | ESCC | 3.18e-35 | 6.52e-01 | 0.1122 |
79009 | DDX50 | P15T-E | Human | Esophagus | ESCC | 6.75e-27 | 4.60e-01 | 0.1149 |
79009 | DDX50 | P16T-E | Human | Esophagus | ESCC | 2.52e-29 | 5.58e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX50 | SNV | Missense_Mutation | rs759074528 | c.2080N>A | p.Gly694Ser | p.G694S | Q9BQ39 | protein_coding | tolerated(0.1) | benign(0.068) | TCGA-49-6761-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DDX50 | SNV | Missense_Mutation | c.1670N>A | p.Gly557Asp | p.G557D | Q9BQ39 | protein_coding | deleterious(0.03) | benign(0.241) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DDX50 | SNV | Missense_Mutation | c.1798N>C | p.Asp600His | p.D600H | Q9BQ39 | protein_coding | tolerated(0.16) | benign(0.052) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
DDX50 | SNV | Missense_Mutation | c.1511N>T | p.Glu504Val | p.E504V | Q9BQ39 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
DDX50 | SNV | Missense_Mutation | c.2005G>C | p.Asp669His | p.D669H | Q9BQ39 | protein_coding | deleterious(0.01) | possibly_damaging(0.85) | TCGA-95-7947-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DDX50 | SNV | Missense_Mutation | c.2112G>C | p.Gln704His | p.Q704H | Q9BQ39 | protein_coding | tolerated_low_confidence(0.34) | benign(0.205) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DDX50 | SNV | Missense_Mutation | novel | c.2135N>A | p.Gly712Glu | p.G712E | Q9BQ39 | protein_coding | deleterious_low_confidence(0.01) | benign(0.093) | TCGA-56-8304-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX50 | insertion | Frame_Shift_Ins | novel | c.943_943+1insTGAGAAGAGAGAAATGCCACCAATAT | p.Asp315ValfsTer36 | p.D315Vfs*36 | Q9BQ39 | protein_coding | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
DDX50 | SNV | Missense_Mutation | novel | c.2209N>C | p.Asp737His | p.D737H | Q9BQ39 | protein_coding | deleterious_low_confidence(0.02) | benign(0.001) | TCGA-CV-5442-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX50 | SNV | Missense_Mutation | rs772750998 | c.1650G>T | p.Gln550His | p.Q550H | Q9BQ39 | protein_coding | deleterious(0.01) | possibly_damaging(0.719) | TCGA-CV-7247-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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