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Gene: CPED1 |
Gene summary for CPED1 |
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Gene information | Species | Human | Gene symbol | CPED1 | Gene ID | 79974 |
Gene name | cadherin like and PC-esterase domain containing 1 | |
Gene Alias | C7orf58 | |
Cytomap | 7q31.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A4D0V7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79974 | CPED1 | NAFLD1 | Human | Liver | NAFLD | 6.82e-09 | 1.05e+00 | -0.04 |
79974 | CPED1 | S41 | Human | Liver | Cirrhotic | 1.29e-06 | 7.24e-01 | -0.0343 |
79974 | CPED1 | HCC1_Meng | Human | Liver | HCC | 5.12e-11 | -3.00e-01 | 0.0246 |
79974 | CPED1 | HCC2_Meng | Human | Liver | HCC | 8.63e-08 | -3.00e-01 | 0.0107 |
79974 | CPED1 | cirrhotic1 | Human | Liver | Cirrhotic | 3.91e-06 | -2.76e-01 | 0.0202 |
79974 | CPED1 | cirrhotic2 | Human | Liver | Cirrhotic | 5.29e-05 | -2.71e-01 | 0.0201 |
79974 | CPED1 | HCC5 | Human | Liver | HCC | 3.97e-02 | -1.01e-02 | 0.4932 |
79974 | CPED1 | Pt13.a | Human | Liver | HCC | 7.34e-07 | -2.89e-01 | 0.021 |
79974 | CPED1 | Pt13.b | Human | Liver | HCC | 3.30e-02 | -2.65e-01 | 0.0251 |
79974 | CPED1 | Pt14.d | Human | Liver | HCC | 2.64e-04 | -2.24e-01 | 0.0143 |
79974 | CPED1 | ATC12 | Human | Thyroid | ATC | 5.85e-06 | 1.41e-01 | 0.34 |
79974 | CPED1 | ATC13 | Human | Thyroid | ATC | 6.92e-24 | 4.61e-01 | 0.34 |
79974 | CPED1 | ATC2 | Human | Thyroid | ATC | 2.94e-10 | 9.95e-01 | 0.34 |
79974 | CPED1 | ATC4 | Human | Thyroid | ATC | 6.35e-09 | 1.93e-01 | 0.34 |
79974 | CPED1 | ATC5 | Human | Thyroid | ATC | 2.90e-24 | 4.85e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPED1 | SNV | Missense_Mutation | c.1776G>T | p.Lys592Asn | p.K592N | A4D0V7 | protein_coding | deleterious(0.05) | benign(0.051) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CPED1 | SNV | Missense_Mutation | novel | c.179G>T | p.Arg60Ile | p.R60I | A4D0V7 | protein_coding | deleterious(0) | possibly_damaging(0.564) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CPED1 | SNV | Missense_Mutation | novel | c.2965C>A | p.Leu989Ile | p.L989I | A4D0V7 | protein_coding | tolerated(0.14) | possibly_damaging(0.657) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CPED1 | SNV | Missense_Mutation | c.1090N>G | p.Phe364Val | p.F364V | A4D0V7 | protein_coding | deleterious(0.05) | benign(0.027) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CPED1 | SNV | Missense_Mutation | c.1594N>T | p.Asp532Tyr | p.D532Y | A4D0V7 | protein_coding | deleterious(0.01) | benign(0.259) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CPED1 | SNV | Missense_Mutation | novel | c.2155C>A | p.Pro719Thr | p.P719T | A4D0V7 | protein_coding | tolerated(0.19) | benign(0.028) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPED1 | SNV | Missense_Mutation | novel | c.659N>A | p.Gly220Glu | p.G220E | A4D0V7 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CPED1 | SNV | Missense_Mutation | rs754935052 | c.2036N>T | p.Thr679Ile | p.T679I | A4D0V7 | protein_coding | tolerated(0.22) | benign(0.005) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
CPED1 | SNV | Missense_Mutation | novel | c.1115N>C | p.Met372Thr | p.M372T | A4D0V7 | protein_coding | tolerated(0.53) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPED1 | SNV | Missense_Mutation | novel | c.2045N>A | p.Gly682Asp | p.G682D | A4D0V7 | protein_coding | deleterious(0.02) | possibly_damaging(0.676) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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