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Gene: CNKSR1 |
Gene summary for CNKSR1 |
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Gene information | Species | Human | Gene symbol | CNKSR1 | Gene ID | 10256 |
Gene name | connector enhancer of kinase suppressor of Ras 1 | |
Gene Alias | CNK | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | B4DL25 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10256 | CNKSR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-06 | 4.57e-01 | -0.1808 |
10256 | CNKSR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.19e-04 | 3.99e-01 | -0.0811 |
10256 | CNKSR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.73e-08 | 3.51e-01 | -0.1954 |
10256 | CNKSR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.01e-05 | 8.62e-01 | -0.2602 |
10256 | CNKSR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.60e-02 | 2.58e-01 | -0.1001 |
10256 | CNKSR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.57e-06 | 3.46e-01 | -0.059 |
10256 | CNKSR1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.06e-02 | 3.38e-01 | -0.0842 |
10256 | CNKSR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.77e-03 | 2.18e-01 | 0.096 |
10256 | CNKSR1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.88e-02 | 4.43e-01 | 0.0112 |
10256 | CNKSR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.07e-03 | 4.02e-01 | 0.281 |
10256 | CNKSR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.47e-07 | 3.78e-01 | 0.3859 |
10256 | CNKSR1 | LZE4T | Human | Esophagus | ESCC | 6.70e-03 | 9.83e-02 | 0.0811 |
10256 | CNKSR1 | LZE5T | Human | Esophagus | ESCC | 7.95e-05 | 2.92e-01 | 0.0514 |
10256 | CNKSR1 | LZE7T | Human | Esophagus | ESCC | 1.51e-06 | 3.08e-01 | 0.0667 |
10256 | CNKSR1 | LZE8T | Human | Esophagus | ESCC | 2.57e-02 | 1.24e-01 | 0.067 |
10256 | CNKSR1 | LZE20T | Human | Esophagus | ESCC | 5.93e-05 | 2.18e-01 | 0.0662 |
10256 | CNKSR1 | LZE22D1 | Human | Esophagus | HGIN | 9.32e-04 | 1.94e-01 | 0.0595 |
10256 | CNKSR1 | LZE22T | Human | Esophagus | ESCC | 1.06e-02 | 2.92e-01 | 0.068 |
10256 | CNKSR1 | LZE24T | Human | Esophagus | ESCC | 8.78e-21 | 5.23e-01 | 0.0596 |
10256 | CNKSR1 | P1T-E | Human | Esophagus | ESCC | 1.82e-10 | 5.56e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:000726610 | Esophagus | ESCC | Rho protein signal transduction | 81/8552 | 137/18723 | 1.03e-03 | 5.20e-03 | 81 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:00072669 | Oral cavity | OSCC | Rho protein signal transduction | 76/7305 | 137/18723 | 6.64e-05 | 5.37e-04 | 76 |
GO:000726515 | Oral cavity | LP | Ras protein signal transduction | 109/4623 | 337/18723 | 8.44e-04 | 7.36e-03 | 109 |
GO:000726516 | Skin | AK | Ras protein signal transduction | 68/1910 | 337/18723 | 2.83e-08 | 1.57e-06 | 68 |
GO:000726616 | Skin | AK | Rho protein signal transduction | 31/1910 | 137/18723 | 1.60e-05 | 3.09e-04 | 31 |
GO:000726523 | Skin | cSCC | Ras protein signal transduction | 132/4864 | 337/18723 | 6.17e-08 | 1.57e-06 | 132 |
GO:000726617 | Skin | cSCC | Rho protein signal transduction | 51/4864 | 137/18723 | 2.38e-03 | 1.38e-02 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNKSR1 | SNV | Missense_Mutation | c.1088G>T | p.Gly363Val | p.G363V | Q969H4 | protein_coding | deleterious(0.04) | benign(0.221) | TCGA-44-8120-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CNKSR1 | SNV | Missense_Mutation | c.708N>C | p.Gln236His | p.Q236H | Q969H4 | protein_coding | tolerated(0.09) | benign(0.005) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CNKSR1 | SNV | Missense_Mutation | novel | c.1846C>T | p.Leu616Phe | p.L616F | Q969H4 | protein_coding | deleterious(0.01) | possibly_damaging(0.603) | TCGA-55-6970-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
CNKSR1 | SNV | Missense_Mutation | novel | c.1072N>T | p.Ala358Ser | p.A358S | Q969H4 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CNKSR1 | SNV | Missense_Mutation | rs775999289 | c.1208N>A | p.Arg403Gln | p.R403Q | Q969H4 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-55-8096-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CNKSR1 | SNV | Missense_Mutation | c.1658N>G | p.Pro553Arg | p.P553R | Q969H4 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-64-5779-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD | |
CNKSR1 | SNV | Missense_Mutation | c.931N>A | p.Ala311Thr | p.A311T | Q969H4 | protein_coding | tolerated(0.52) | benign(0.001) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
CNKSR1 | SNV | Missense_Mutation | c.367N>T | p.Asp123Tyr | p.D123Y | Q969H4 | protein_coding | deleterious(0.01) | benign(0.038) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CNKSR1 | SNV | Missense_Mutation | c.1480N>T | p.Val494Leu | p.V494L | Q969H4 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CNKSR1 | SNV | Missense_Mutation | novel | c.1945N>G | p.Leu649Val | p.L649V | Q969H4 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-J2-A4AD-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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