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Gene: CMKLR1 |
Gene summary for CMKLR1 |
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Gene information | Species | Human | Gene symbol | CMKLR1 | Gene ID | 1240 |
Gene name | chemerin chemokine-like receptor 1 | |
Gene Alias | CHEMERINR | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q99788 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1240 | CMKLR1 | ATC12 | Human | Thyroid | ATC | 1.19e-10 | 3.72e-01 | 0.34 |
1240 | CMKLR1 | ATC2 | Human | Thyroid | ATC | 7.49e-03 | 5.69e-01 | 0.34 |
1240 | CMKLR1 | ATC4 | Human | Thyroid | ATC | 6.15e-14 | 4.78e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109022 | Thyroid | ATC | regulation of DNA-binding transcription factor activity | 190/6293 | 440/18723 | 1.49e-05 | 1.39e-04 | 190 |
GO:005092123 | Thyroid | ATC | positive regulation of chemotaxis | 70/6293 | 141/18723 | 5.77e-05 | 4.43e-04 | 70 |
GO:004544423 | Thyroid | ATC | fat cell differentiation | 105/6293 | 229/18723 | 7.42e-05 | 5.62e-04 | 105 |
GO:003210324 | Thyroid | ATC | positive regulation of response to external stimulus | 178/6293 | 427/18723 | 2.61e-04 | 1.67e-03 | 178 |
GO:000268719 | Thyroid | ATC | positive regulation of leukocyte migration | 65/6293 | 135/18723 | 3.18e-04 | 1.99e-03 | 65 |
GO:010610621 | Thyroid | ATC | cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:012016121 | Thyroid | ATC | regulation of cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:00509206 | Thyroid | ATC | regulation of chemotaxis | 99/6293 | 223/18723 | 4.91e-04 | 2.86e-03 | 99 |
GO:000269023 | Thyroid | ATC | positive regulation of leukocyte chemotaxis | 47/6293 | 94/18723 | 7.32e-04 | 4.11e-03 | 47 |
GO:199084521 | Thyroid | ATC | adaptive thermogenesis | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
GO:000268818 | Thyroid | ATC | regulation of leukocyte chemotaxis | 57/6293 | 122/18723 | 1.77e-03 | 8.71e-03 | 57 |
GO:000268519 | Thyroid | ATC | regulation of leukocyte migration | 90/6293 | 210/18723 | 3.11e-03 | 1.40e-02 | 90 |
GO:00508483 | Thyroid | ATC | regulation of calcium-mediated signaling | 36/6293 | 73/18723 | 3.91e-03 | 1.70e-02 | 36 |
GO:00434333 | Thyroid | ATC | negative regulation of DNA-binding transcription factor activity | 79/6293 | 185/18723 | 5.96e-03 | 2.40e-02 | 79 |
GO:01201625 | Thyroid | ATC | positive regulation of cold-induced thermogenesis | 45/6293 | 97/18723 | 5.97e-03 | 2.40e-02 | 45 |
GO:007167516 | Thyroid | ATC | regulation of mononuclear cell migration | 52/6293 | 115/18723 | 6.24e-03 | 2.50e-02 | 52 |
GO:004559822 | Thyroid | ATC | regulation of fat cell differentiation | 61/6293 | 139/18723 | 7.28e-03 | 2.86e-02 | 61 |
GO:004560023 | Thyroid | ATC | positive regulation of fat cell differentiation | 32/6293 | 66/18723 | 8.63e-03 | 3.28e-02 | 32 |
GO:000165912 | Thyroid | ATC | temperature homeostasis | 73/6293 | 174/18723 | 1.29e-02 | 4.51e-02 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Breast | DCIS |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Breast | IDC |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Cervix | CC |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | CRC | AD |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | CRC | SER |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | HNSCC | OSCC |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Liver | Healthy |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Lung | AAH |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | ADJ |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | Cancer |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | Precancer |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | PTC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CMKLR1 | SNV | Missense_Mutation | c.380T>A | p.Val127Asp | p.V127D | Q99788 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-8254-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CMKLR1 | SNV | Missense_Mutation | c.707N>G | p.Ile236Ser | p.I236S | Q99788 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
CMKLR1 | SNV | Missense_Mutation | c.491N>T | p.Trp164Leu | p.W164L | Q99788 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CMKLR1 | SNV | Missense_Mutation | c.488N>A | p.Ile163Asn | p.I163N | Q99788 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CMKLR1 | SNV | Missense_Mutation | novel | c.940N>T | p.Ile314Phe | p.I314F | Q99788 | protein_coding | tolerated(0.09) | benign(0.085) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CMKLR1 | SNV | Missense_Mutation | novel | c.779N>G | p.Lys260Arg | p.K260R | Q99788 | protein_coding | tolerated(0.3) | possibly_damaging(0.572) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CMKLR1 | SNV | Missense_Mutation | rs370161103 | c.1093N>G | p.Met365Val | p.M365V | Q99788 | protein_coding | tolerated(1) | benign(0) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CMKLR1 | SNV | Missense_Mutation | novel | c.587N>T | p.Ser196Phe | p.S196F | Q99788 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-43-8118-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
CMKLR1 | SNV | Missense_Mutation | c.957G>T | p.Met319Ile | p.M319I | Q99788 | protein_coding | tolerated(0.09) | benign(0.145) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CMKLR1 | SNV | Missense_Mutation | novel | c.391N>C | p.Thr131Pro | p.T131P | Q99788 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-60-2720-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100364 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100428 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | CCX832 | |||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651892 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 354702257 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651571 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 354702254 |
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