![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CLK2 |
Gene summary for CLK2 |
![]() |
Gene information | Species | Human | Gene symbol | CLK2 | Gene ID | 1196 |
Gene name | CDC like kinase 2 | |
Gene Alias | CLK2 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A8K7I0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1196 | CLK2 | LZE4T | Human | Esophagus | ESCC | 9.12e-07 | 1.32e-01 | 0.0811 |
1196 | CLK2 | LZE7T | Human | Esophagus | ESCC | 1.23e-06 | 2.91e-01 | 0.0667 |
1196 | CLK2 | LZE20T | Human | Esophagus | ESCC | 4.51e-02 | 4.74e-02 | 0.0662 |
1196 | CLK2 | LZE24T | Human | Esophagus | ESCC | 3.22e-12 | 1.79e-01 | 0.0596 |
1196 | CLK2 | LZE6T | Human | Esophagus | ESCC | 8.22e-03 | 9.53e-02 | 0.0845 |
1196 | CLK2 | P1T-E | Human | Esophagus | ESCC | 1.70e-09 | 2.35e-01 | 0.0875 |
1196 | CLK2 | P2T-E | Human | Esophagus | ESCC | 1.19e-22 | 3.05e-01 | 0.1177 |
1196 | CLK2 | P4T-E | Human | Esophagus | ESCC | 3.95e-18 | 2.25e-01 | 0.1323 |
1196 | CLK2 | P5T-E | Human | Esophagus | ESCC | 5.81e-21 | 2.39e-01 | 0.1327 |
1196 | CLK2 | P8T-E | Human | Esophagus | ESCC | 6.48e-15 | 1.68e-01 | 0.0889 |
1196 | CLK2 | P9T-E | Human | Esophagus | ESCC | 2.00e-14 | 1.74e-01 | 0.1131 |
1196 | CLK2 | P10T-E | Human | Esophagus | ESCC | 1.68e-23 | 2.50e-01 | 0.116 |
1196 | CLK2 | P11T-E | Human | Esophagus | ESCC | 4.46e-03 | 8.65e-02 | 0.1426 |
1196 | CLK2 | P12T-E | Human | Esophagus | ESCC | 8.78e-08 | 1.02e-01 | 0.1122 |
1196 | CLK2 | P15T-E | Human | Esophagus | ESCC | 5.59e-18 | 2.29e-01 | 0.1149 |
1196 | CLK2 | P16T-E | Human | Esophagus | ESCC | 2.81e-14 | 1.02e-01 | 0.1153 |
1196 | CLK2 | P17T-E | Human | Esophagus | ESCC | 4.81e-03 | 1.30e-01 | 0.1278 |
1196 | CLK2 | P20T-E | Human | Esophagus | ESCC | 2.31e-06 | 1.30e-01 | 0.1124 |
1196 | CLK2 | P21T-E | Human | Esophagus | ESCC | 1.18e-09 | 8.09e-02 | 0.1617 |
1196 | CLK2 | P22T-E | Human | Esophagus | ESCC | 9.83e-15 | 1.29e-01 | 0.1236 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:001021217 | Esophagus | ESCC | response to ionizing radiation | 110/8552 | 148/18723 | 1.11e-12 | 4.78e-11 | 110 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:00060069 | Esophagus | ESCC | glucose metabolic process | 119/8552 | 196/18723 | 1.51e-05 | 1.36e-04 | 119 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
GO:00463643 | Esophagus | ESCC | monosaccharide biosynthetic process | 52/8552 | 82/18723 | 9.03e-04 | 4.61e-03 | 52 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00109065 | Esophagus | ESCC | regulation of glucose metabolic process | 71/8552 | 119/18723 | 1.46e-03 | 6.92e-03 | 71 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:00193193 | Esophagus | ESCC | hexose biosynthetic process | 49/8552 | 78/18723 | 1.69e-03 | 7.81e-03 | 49 |
GO:00061096 | Esophagus | ESCC | regulation of carbohydrate metabolic process | 101/8552 | 178/18723 | 1.89e-03 | 8.52e-03 | 101 |
GO:00106755 | Esophagus | ESCC | regulation of cellular carbohydrate metabolic process | 83/8552 | 146/18723 | 4.24e-03 | 1.69e-02 | 83 |
GO:00060943 | Esophagus | ESCC | gluconeogenesis | 46/8552 | 75/18723 | 4.54e-03 | 1.78e-02 | 46 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLK2 | SNV | Missense_Mutation | c.1405N>G | p.Thr469Ala | p.T469A | P49760 | protein_coding | deleterious(0.03) | benign(0.027) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLK2 | SNV | Missense_Mutation | c.1399N>T | p.Arg467Trp | p.R467W | P49760 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CLK2 | SNV | Missense_Mutation | rs771821636 | c.1441C>T | p.Arg481Cys | p.R481C | P49760 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLK2 | SNV | Missense_Mutation | rs759554148 | c.1294N>T | p.Arg432Cys | p.R432C | P49760 | protein_coding | deleterious(0.02) | benign(0.373) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLK2 | SNV | Missense_Mutation | c.1043N>A | p.Arg348Gln | p.R348Q | P49760 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLK2 | SNV | Missense_Mutation | c.938N>T | p.Arg313Leu | p.R313L | P49760 | protein_coding | tolerated(0.05) | possibly_damaging(0.781) | TCGA-CD-8527-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | epirubicin | PD | |
CLK2 | SNV | Missense_Mutation | c.583N>G | p.Ile195Val | p.I195V | P49760 | protein_coding | tolerated(0.3) | possibly_damaging(0.727) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CLK2 | SNV | Missense_Mutation | rs201854491 | c.362N>A | p.Arg121Gln | p.R121Q | P49760 | protein_coding | tolerated(0.08) | probably_damaging(0.953) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
CLK2 | SNV | Missense_Mutation | c.1315N>T | p.Arg439Trp | p.R439W | P49760 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLK2 | SNV | Missense_Mutation | c.1102N>T | p.Gly368Cys | p.G368C | P49760 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | GATIFLOXACIN | GATIFLOXACIN | ||
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | RG-1530 | RG-1530 | ||
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | CYC-116 | CYC-116 | ||
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | LEUCETTAMINE B | LEUCETTAMINE B | 22998443 | |
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | BAY-613606 | CHEMBL541400 | ||
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | DNDI1417467 | CHEMBL1997335 | ||
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | HARMINE | HARMINE | 22998443 | |
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | SB-220025 | SB-220025 | ||
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | PHA-767491 | CHEMBL225519 | ||
1196 | CLK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | JNJ-7706621 | JNJ-7706621 |
Page: 1 2 3 |